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GENE：PSMC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSMC4
FullNmae proteasome 26S subunit, ATPase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9551
EnsembleID ENSG00000013275
Uniprot P43686

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSMC4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMC4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PSMC4 GO:0000502,GO:0000502,GO:0001824,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0005829,GO:0006508,GO:0008540,GO:0016020,GO:0016887,GO:0022624,GO:0036402,GO:0043161,GO:0043161,GO:1901800

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSMC4 hsa:5704 path:hsa03050 Proteasome - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05012 Parkinson disease - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05016 Huntington disease - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05020 Prion disease - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PSMC4 hsa:5704 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PSMC4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PSMC4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PSMC4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PSMC4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PSMC4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PSMC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PSMC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PSMC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PSMC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PSMC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PSMC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PSMC4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PSMC4 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D PSMC4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC PSMC4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 PSMC4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000171CD1 PSMC4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000355E82 PSMC4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A PSMC4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 PSMC4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 PSMC4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C PSMC4 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DYRK2 PSMC4 22135298 phosphorylation N/A PhosphoSite
PSMA4 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMA4 25361965 interaction type N/A PTMCode2
PSMC4 PSMD5 25361965 interaction type N/A PTMCode2
PSMD5 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMA3 25361965 interaction type N/A PTMCode2
PSMA3 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMD10 25361965 interaction type N/A PTMCode2
PSMD10 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMD7 25361965 interaction type N/A PTMCode2
PSMD7 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMC1 25361965 interaction type N/A PTMCode2
PSMC1 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 USP14 25361965 interaction type N/A PTMCode2
USP14 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMD11 25361965 interaction type N/A PTMCode2
PSMD11 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMA5 25361965 interaction type N/A PTMCode2
PSMA5 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMC3 25361965 interaction type N/A PTMCode2
PSMC3 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMD1 25361965 interaction type N/A PTMCode2
PSMD1 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PAAF1 25361965 interaction type N/A PTMCode2
PAAF1 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMA1 25361965 interaction type N/A PTMCode2
PSMA1 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMB10 25361965 interaction type N/A PTMCode2
PSMB10 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMA7 25361965 interaction type N/A PTMCode2
PSMA7 PSMC4 25361965 interaction type N/A PTMCode2
PSMC4 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMC4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 PSMC4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L PSMC4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC42 PSMC4 25348397 N/A two hybrid ComPPI
RPS7 PSMC4 25348397 N/A physical interaction ComPPI
NPM1 PSMC4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSMC3 PSMC4 11463857 14525934 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PSMC6 PSMC4 19490896 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
PSMD14 PSMC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HTR1E PSMC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP1 PSMC4 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
TRAF6 PSMC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMD7 PSMC4 17353931 19615732 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP PSMC4 25348397 N/A physical interaction ComPPI
PPFIA1 PSMC4 25348397 N/A physical interaction ComPPI
KEAP1 PSMC4 25348397 N/A physical interaction ComPPI
KRT33B PSMC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB2 PSMC4 25348397 N/A physical interaction ComPPI
KXD1 PSMC4 25348397 N/A physical interaction ComPPI
ABRAXAS2 PSMC4 19214193 24234451 25348397 association biochemical ComPPI,IntAct
TTF2 PSMC4 25348397 N/A physical interaction ComPPI
JUN PSMC4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
RB1 PSMC4 17292836 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
FLNC PSMC4 25348397 N/A physical interaction ComPPI
PSMA3 PSMC4 25348397 N/A physical interaction ComPPI
PSMD11 PSMC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL3 PSMC4 25348397 N/A physical interaction ComPPI
TUBA1B PSMC4 25348397 N/A physical interaction ComPPI
UBC PSMC4 25348397 N/A physical interaction ComPPI
DLD PSMC4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 PSMC4 25348397 N/A physical interaction ComPPI
NR1I3 PSMC4 25348397 N/A physical interaction ComPPI
YBX1 PSMC4 25348397 N/A physical interaction ComPPI
PTPN2 PSMC4 25348397 N/A physical interaction ComPPI
PSMA1 PSMC4 25348397 N/A physical interaction ComPPI
PSMA6 PSMC4 25348397 N/A physical interaction ComPPI
PSMA5 PSMC4 25348397 N/A physical interaction ComPPI
PSMB9 PSMC4 25348397 N/A physical interaction ComPPI
MAP3K5 PSMC4 25348397 N/A physical interaction ComPPI
MYC PSMC4 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRIP6 PSMC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TUBA4A PSMC4 25348397 N/A physical interaction ComPPI
CAD PSMC4 25348397 N/A physical interaction ComPPI
CFTR PSMC4 25348397 N/A physical interaction ComPPI
MAPK6 PSMC4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMD8 PSMC4 25348397 N/A physical interaction ComPPI
PSMB8 PSMC4 25348397 N/A physical interaction ComPPI
PSMD1 PSMC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AHR PSMC4 25348397 N/A physical interaction ComPPI
RBBP4 PSMC4 25348397 N/A physical interaction ComPPI
TRAP1 PSMC4 21979464 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMC5 PSMC4 14525934 16189514 17353931 19490896 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
HUWE1 PSMC4 25348397 N/A physical interaction ComPPI
RAD23A PSMC4 25348397 N/A physical interaction ComPPI
ACTR1A PSMC4 25348397 N/A physical interaction ComPPI
PSMC4 PSMD10 11779854 12525503 14525934 16189514 17353931 19490896 21988832 24234451 24338975 25348397 25416956 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PSMC4 PAAF1 14525934 15831487 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PSMC4 RORB 25348397 N/A two hybrid,physical interaction ComPPI
PSMC4 PSMC2 11361004 14525934 17353931 22901813 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PSMC4 PSMD2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 PSMD13 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 PAICS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 BAG2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 PSMD6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 PSMC1 17353931 19490896 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC4 CMYA5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 RIOK3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 UCHL5 18922472 19490896 19615732 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 USP14 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 ATG4C 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 RNF2 15773819 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMC4 SRRM2 25348397 N/A physical interaction ComPPI
PSMC4 HDAC5 25348397 N/A physical interaction ComPPI
PSMC4 PCK1 25348397 N/A physical interaction ComPPI
PSMC4 SEM1 25348397 N/A physical interaction ComPPI
PSMC4 FKBP8 25348397 N/A physical interaction ComPPI
PSMC4 PSMB5 25348397 N/A physical interaction ComPPI
PSMC4 TRIM5 25348397 N/A physical interaction ComPPI
PSMC4 SNCAIP 17327361 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMC4 PFDN5 25348397 N/A physical interaction ComPPI
PSMC4 PSMA2 25348397 N/A physical interaction ComPPI
PSMC4 PRAME 25348397 N/A physical interaction ComPPI
PSMC4 PSMD12 25348397 N/A physical interaction ComPPI
PSMC4 PSMD3 25348397 N/A physical interaction ComPPI
PSMC4 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 PSMA7 25348397 N/A physical interaction ComPPI
PSMC4 PSMB7 25348397 N/A physical interaction ComPPI
PSMC4 PSMB6 25348397 N/A physical interaction ComPPI
PSMC4 PSMA4 25348397 N/A physical interaction ComPPI
PSMC4 PSME1 25348397 N/A physical interaction ComPPI
PSMC4 PSME2 25348397 N/A physical interaction ComPPI
PSMC4 PSMA8 25348397 N/A physical interaction ComPPI
PSMC4 DCTN2 25348397 N/A physical interaction ComPPI
PSMC4 TMOD3 25348397 N/A physical interaction ComPPI
PSMC4 ZCCHC8 25348397 N/A physical interaction ComPPI
PSMC4 SMURF1 25348397 N/A physical interaction ComPPI
PSMC4 NOS2 25348397 N/A physical interaction ComPPI
PSMC4 PRKN 25348397 N/A physical interaction ComPPI
PSMC4 MOV10 25348397 N/A physical interaction ComPPI
PSMC4 NXF1 25348397 N/A physical interaction ComPPI
PSMC4 CCDC74B 25348397 N/A physical interaction ComPPI
PSMC4 CCDC92 25348397 N/A physical interaction ComPPI
PSMC4 FBXW11 25348397 N/A physical interaction ComPPI
PSMC4 AMBRA1 25348397 N/A physical interaction ComPPI
PSMC4 AHSA1 25348397 N/A physical interaction ComPPI
PSMC4 DNAJA2 25348397 N/A physical interaction ComPPI
PSMC4 ELP6 25348397 N/A physical interaction ComPPI
PSMC4 FTSJ3 25348397 N/A physical interaction ComPPI
PSMC4 GFPT1 25348397 N/A physical interaction ComPPI
PSMC4 ELP1 25348397 N/A physical interaction ComPPI
PSMC4 LONP1 25348397 N/A physical interaction ComPPI
PSMC4 MCFD2 25348397 N/A physical interaction ComPPI
PSMC4 MTCH1 25348397 N/A physical interaction ComPPI
PSMC4 PSMD5 19490896 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC4 PSMD9 25348397 N/A physical interaction ComPPI
PSMC4 RAD23B 25348397 N/A physical interaction ComPPI
PSMC4 RFC5 25348397 N/A physical interaction ComPPI
PSMC4 TMEM67 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PSMC4 CENPJ 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PSMC4 CRY1 25348397 N/A physical interaction ComPPI
PSMC4 CRY2 25348397 N/A physical interaction ComPPI
PSMC4 HERC3 25348397 N/A physical interaction ComPPI
PSMC4 GPAM 25348397 N/A physical interaction ComPPI
PSMC4 MYO1D 25348397 N/A physical interaction ComPPI
PSMC4 KIAA0100 25348397 N/A physical interaction ComPPI
PSMC4 SMC2 25348397 N/A physical interaction ComPPI
PSMC4 ZFAND2B 25348397 N/A physical interaction ComPPI
PSMC4 RAB3GAP1 25348397 N/A physical interaction ComPPI
PSMC4 INTU 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PSMC4 USP44 25348397 N/A physical interaction ComPPI
PSMC4 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC4 DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC4 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC4 CCND2 25348397 N/A physical interaction ComPPI
PSMC4 BRCA1 25348397 N/A physical interaction ComPPI
PSMC4 FBXO32 25348397 N/A physical interaction ComPPI
PSMC4 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMC4 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMC4 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMC4 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMC4 ASXL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMC4 BAP1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMC4 L3MBTL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMC4 ESR1 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
PSMC4 ESR2 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
PSMC4 PPM1G 24234451 25348397 28330616 association pull down ComPPI,IntAct
SEM1 PSMC4 25348397 N/A physical interaction ComPPI
PSMB4 PSMC4 25348397 N/A physical interaction ComPPI
PSMB1 PSMC4 25348397 N/A physical interaction ComPPI
PSMB3 PSMC4 25348397 N/A physical interaction ComPPI
ADRM1 PSMC4 24234451 24811749 25348397 association physical interaction,blue native page ComPPI,IntAct
UBLCP1 PSMC4 25348397 N/A physical interaction ComPPI
ECPAS PSMC4 25348397 N/A physical interaction ComPPI
METTL3 PSMC4 24234451 29507755 association anti tag coimmunoprecipitation IntAct

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