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GENE：SH2D2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SH2D2A
FullNmae SH2 domain containing 2A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10821
EnsembleID ENSG00000027869
Uniprot Q9NP31

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SH2D2A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SH2D2A GO:0001525,GO:0005515,GO:0005737,GO:0005829,GO:0007165,GO:0017124,GO:0030154,GO:0042098

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SH2D2A hsa:9047 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SH2D2A LCK 10975797 26192618 27896837 interaction type N/A ACSN
SH2D2A CD4 10975797 26192618 27896837 interaction type N/A ACSN
SMAD2 SH2D2A 16806069 23180781 physical association two hybrid,pull down InnateDB
SMAD3 SH2D2A 16806069 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
SH2D2A ERBB2 20005715 interaction type N/A PSP,SignaLink
SH2D2A LCK 10553045 18988627 20005715 interaction type N/A PSP,SignaLink
SH2D2A PLCG1 20005715 interaction type N/A PSP
SH2D2A KDR 10692392 15962004 18988627 20005715 interaction type N/A PSP,SignaLink
SH2D2A ITK 20005715 interaction type N/A PSP
SH2D2A MAP3K2 20005715 interaction type N/A PSP
SH2D2A ITK 10587356 18988627 20005715 20005715 N/A N/A SignaLink
SH2D2A MAP3K2 11073940 11073940 20005715 20005715 21071413 N/A N/A SignaLink
SH2D2A PLCG1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 SH2D2A 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 SH2D2A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SH2D2A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA SH2D2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SH2D2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SH2D2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
LCK SH2D2A 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
ARID5A SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SOCS3 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
VCP SH2D2A 15752563 24234451 25348397 27898060 association pull down,physical interaction ComPPI,IntAct,OmniPath
CRK SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
APPL1 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
ERBB2 SH2D2A 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
SYK SH2D2A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KIT SH2D2A 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R1 SH2D2A 25348397 N/A physical interaction ComPPI
SRC SH2D2A 25348397 N/A physical interaction ComPPI
LCK SH2D2A 10553045 14525934 15827961 16839418 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down ComPPI,HPRD,IntAct
KDR SH2D2A 10692392 14525934 15962004 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
AR SH2D2A 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SMAD2 SH2D2A 25348397 N/A physical interaction ComPPI
SMAD3 SH2D2A 25348397 N/A physical interaction ComPPI
GAB1 SH2D2A 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R3 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
LASP1 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
RAD54B SH2D2A 25348397 N/A physical interaction ComPPI
MAPK7 SH2D2A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MET SH2D2A 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SPTB SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
EGFR SH2D2A 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
TENT5A SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
ZHX3 SH2D2A 25348397 N/A physical interaction ComPPI
PLEKHB1 SH2D2A 25348397 N/A physical interaction ComPPI
TSC1 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
LRRFIP1 SH2D2A 25348397 N/A physical interaction ComPPI
MAP3K2 SH2D2A 12640115 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
STAT3 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
LNX1 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
TENT5B SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
NAA16 SH2D2A 25348397 N/A physical interaction ComPPI
PTK2 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
FSBP SH2D2A 25348397 N/A physical interaction ComPPI
ASB3 SH2D2A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
SH2D2A KDM1B 25348397 N/A physical interaction ComPPI
SH2D2A PEAK1 25348397 N/A physical interaction ComPPI
SH2D2A PPP1R21 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SH2D2A DCAF12L1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
SH2D2A ZSCAN1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SH2D2A LINC02875 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SH2D2A DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
SH2D2A MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
HAVCR2 SH2D2A 24234451 25348397 26492563 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
SH2D2A ITK 10587356 14525934 N/A two hybrid HPRD
SH2D2A TXK 10587356 14525934 N/A two hybrid HPRD
PLCG1 SH2D2A 10692392 14525934 N/A experimental interaction detection HPRD
LCK SH2D2A 10553045 15827961 16839418 18541536 27898060 N/A N/A OmniPath

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