Gene Information gene info

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GENE：CHEK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CHEK2
FullNmae checkpoint kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16627
EnsembleID ENSG00000183765
Uniprot O96017

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CHEK2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHEK2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHEK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHEK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHEK2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CHEK2 anoikis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CHEK2 GO:0000077,GO:0000086,GO:0000781,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005794,GO:0006302,GO:0006302,GO:0006355,GO:0006468,GO:0006974,GO:0006974,GO:0006974,GO:0006977,GO:0006978,GO:0008630,GO:0008630,GO:0016605,GO:0019901,GO:0030163,GO:0031573,GO:0031625,GO:0042176,GO:0042770,GO:0042770,GO:0042771,GO:0042802,GO:0042803,GO:0044773,GO:0045893,GO:0046777,GO:0046872,GO:0050821,GO:0051301,GO:0070242,GO:0071480,GO:0090307,GO:0090399,GO:0106310,GO:1901796

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CHEK2 hsa:11200 path:hsa04110 Cell cycle - Homo sapiens (human)
CHEK2 hsa:11200 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
CHEK2 hsa:11200 path:hsa04218 Cellular senescence - Homo sapiens (human)
CHEK2 hsa:11200 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CHEK2 CDC25A 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263 26192618 interaction type N/A ACSN
CHEK2 XRCC1 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263 26192618 interaction type N/A ACSN
ATM CHEK2 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 26192618 7575488 9407949 9488723 interaction type N/A ACSN
ATR CHEK2 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 26192618 9488723 9858600 interaction type N/A ACSN
MDC1 CHEK2 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 26192618 7575488 9407949 9488723 interaction type N/A ACSN
MRE11 CHEK2 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 26192618 7575488 9407949 9488723 interaction type N/A ACSN
RAD50 CHEK2 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 26192618 7575488 9407949 9488723 interaction type N/A ACSN
CHEK2 FANCE 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263 26192618 interaction type N/A ACSN
CHEK2 BRCA1 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263 26192618 interaction type N/A ACSN
CHEK2 ATM 10713094 23180781 phosphorylation reaction in-gel kinase assay InnateDB
CHEK2 ELAVL1 17317627 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
SRPK1 CHEK2 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
MDC1 CHEK2 20005715 interaction type N/A PSP
PPP2R5A CHEK2 20005715 interaction type N/A PSP
PPP2R5B CHEK2 20005715 interaction type N/A PSP
PPP2R5C CHEK2 20005715 interaction type N/A PSP
PPP2R5D CHEK2 20005715 interaction type N/A PSP
PPP2R5E CHEK2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR CHEK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CHEK2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F6 CHEK2 12909625 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ESR1 CHEK2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CHEK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CHEK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C CHEK2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CHEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CHEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CHEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CHEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CHEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CHEK2 15024084 trascriptional regulation,stimulation inferred by curator TFlink
MYC CHEK2 23269272 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CHEK2 10531348 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001CC379 CHEK2 23249749 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000003ABC4 CHEK2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 CHEK2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 CHEK2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001B9F58 CHEK2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F CHEK2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 CHEK2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 CHEK2 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075A513 CHEK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 CHEK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000258D51 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 CHEK2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 CHEK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075D50C CHEK2 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK2 TP53 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CHEK2 E2F3 22135298 phosphorylation N/A PhosphoSite
CHEK2 SIAH2 22135298 phosphorylation N/A PhosphoSite
CHEK2 CHEK2 22135298 phosphorylation N/A PhosphoSite
CHEK2 TTK 22135298 phosphorylation N/A PhosphoSite
CHEK2 AATF 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CHEK2 XRCC1 22135298 phosphorylation N/A PhosphoSite
CHEK2 CDC25A 22135298 phosphorylation N/A PhosphoSite
CHEK2 LATS2 22135298 phosphorylation N/A PhosphoSite
CHEK2 PSME3 22135298 phosphorylation N/A PhosphoSite
CHEK2 ELAVL1 22135298 phosphorylation N/A PhosphoSite
CHEK2 CDK11B 22135298 phosphorylation N/A PhosphoSite
CHEK2 E2F1 22135298 phosphorylation N/A PhosphoSite
CHEK2 BLM 22135298 phosphorylation N/A PhosphoSite
CHEK2 H1-2 22135298 phosphorylation N/A PhosphoSite
CHEK2 BRCA1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CHEK2 VHL 22135298 phosphorylation N/A PhosphoSite
CHEK2 TRIM28 22135298 phosphorylation N/A PhosphoSite
CHEK2 MDM4 22135298 phosphorylation N/A PhosphoSite
CHEK2 BDNF 22135298 phosphorylation N/A PhosphoSite
CHEK2 CDC25C 22135298 phosphorylation N/A PhosphoSite
CHEK2 RB1 22135298 phosphorylation N/A PhosphoSite
CHEK2 REV3L 22135298 phosphorylation N/A PhosphoSite
PRKDC CHEK2 22135298 phosphorylation N/A PhosphoSite
PLK1 CHEK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ATR CHEK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ATM CHEK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
TTK CHEK2 22135298 phosphorylation N/A PhosphoSite
PLK3 CHEK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K20 CHEK2 22135298 phosphorylation N/A PhosphoSite
KPNA2 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 KPNA2 25361965 interaction type N/A PTMCode2
AATF CHEK2 25361965 interaction type N/A PTMCode2
TP53BP1 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 TP53BP1 25361965 interaction type N/A PTMCode2
CHEK2 ATM 25361965 interaction type N/A PTMCode2
MSH2 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 MSH2 25361965 interaction type N/A PTMCode2
CHEK2 PLK1 25361965 interaction type N/A PTMCode2
CHEK2 MDC1 25361965 interaction type N/A PTMCode2
MDC1 CHEK2 25361965 interaction type N/A PTMCode2
ERCC6 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 ERCC6 25361965 interaction type N/A PTMCode2
BRCA1 CHEK2 25361965 interaction type N/A PTMCode2
NBN CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 NBN 25361965 interaction type N/A PTMCode2
RAD9A CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 RAD9A 25361965 interaction type N/A PTMCode2
CHEK2 ATR 25361965 interaction type N/A PTMCode2
TP53 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 PLK3 25361965 interaction type N/A PTMCode2
PPP2R5B CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 PPP2R5B 25361965 interaction type N/A PTMCode2
PPP2R2B CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 PPP2R2B 25361965 interaction type N/A PTMCode2
DBF4 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 DBF4 25361965 interaction type N/A PTMCode2
PER3 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 PER3 25361965 interaction type N/A PTMCode2
BRCA2 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 BRCA2 25361965 interaction type N/A PTMCode2
RAD50 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 RAD50 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 CHEK2 12909615 14525934 23178491 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
HNRNPK CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
POLR2L CHEK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LRATD2 CHEK2 24234451 25348397 25640309 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,fluorescence microscopy ComPPI,IntAct
PCBP1 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PPP2R1A CHEK2 23178491 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TP53BP1 CHEK2 17525332 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP CHEK2 17525332 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MCM5 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SLC25A6 CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BEX1 CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TEX264 CHEK2 25348397 N/A physical interaction ComPPI
PRDM14 CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ASF1A CHEK2 11172707 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK1 CHEK2 25348397 N/A physical interaction ComPPI
SIAH2 CHEK2 25348397 26751770 27898060 N/A physical interaction ComPPI,OmniPath
ATR CHEK2 10973490 11715017 12024051 12493754 14525934 25348397 9857181 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKDC CHEK2 25348397 N/A physical interaction ComPPI
MAPK3 CHEK2 25348397 N/A physical interaction ComPPI
RB1 CHEK2 17380128 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,protein kinase assay ComPPI,IntAct
DHX9 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MYBBP1A CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
USP7 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SF3B1 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NONO CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KAT2B CHEK2 25348397 N/A physical interaction ComPPI
SFPQ CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
ARHGAP1 CHEK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GTF2I CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KPNB1 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
UBB CHEK2 25348397 N/A pull down,physical interaction ComPPI
UBC CHEK2 25348397 N/A pull down,physical interaction ComPPI
RPS27A CHEK2 25348397 N/A pull down,physical interaction ComPPI
UBA52 CHEK2 25348397 N/A pull down,physical interaction ComPPI
ENO1 CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RUVBL1 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PRPF40A CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
XRCC1 CHEK2 18971944 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct
BUB3 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
XRCC5 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CCL5 CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PPP2R5A CHEK2 14525934 15380617 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
E2F1 CHEK2 12717439 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAD9A CHEK2 12049741 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PLK1 CHEK2 10973490 11901158 12024051 12242661 12493754 14525934 20126263 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,phosphorylation reaction,physical interaction,fluorescence microscopy,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
HNRNPU CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CSNK2A1 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
UBR5 CHEK2 17074762 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TPR CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PPP2R5C CHEK2 14525934 15380617 23178491 24234451 25348397 association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
PPP2CA CHEK2 23178491 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DAPK3 CHEK2 25348397 N/A physical interaction ComPPI
PPP2R5E CHEK2 14525934 15380617 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
PKM CHEK2 23178491 24234451 25348397 association protein kinase assay,tandem affinity purification ComPPI,IntAct
BRCA2 CHEK2 25348397 N/A physical interaction ComPPI
ATM CHEK2 10973490 11901158 12024051 12242661 12493754 14525934 16794575 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MDM4 CHEK2 14525934 16163388 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AATF CHEK2 14525934 17157788 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
PRMT2 CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RNF8 CHEK2 25348397 N/A pull down,physical interaction,physical interaction ComPPI
PSMC3IP CHEK2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SRPK1 CHEK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CSNK2A2 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MDM2 CHEK2 14525934 15862297 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMC1A CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
AP1B1 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CUL1 CHEK2 25348397 N/A physical interaction ComPPI
CUL4A CHEK2 25348397 N/A physical interaction ComPPI
SYNCRIP CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
VHL CHEK2 25348397 N/A physical interaction ComPPI
NR4A1 CHEK2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FKBP4 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
LMNB1 CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PER3 CHEK2 21070773 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
TRIM28 CHEK2 25348397 N/A physical interaction ComPPI
CHEK2 BRCA1 10724175 12111733 14525934 17525332 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CHEK2 NBN 11438675 14525934 24234451 25348397 phosphorylation reaction,colocalization experimental interaction detection,imaging technique,in vitro ComPPI,HPRD,IntAct
CHEK2 MDC1 12551934 12607004 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CHEK2 CDC25A 10724175 11298456 12676583 14525934 24234451 25348397 phosphorylation reaction coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CHEK2 MSH2 12447371 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CHEK2 PPP2R5B 14525934 15380617 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CHEK2 PPP2R2A 14525934 15380617 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CHEK2 DBF4 12441400 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
CHEK2 ERCC6 14525934 25348397 9450932 N/A experimental interaction detection,in vitro ComPPI,HPRD
CHEK2 MRC1 11715017 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CHEK2 CDC25C 10557092 10744722 11333986 11551930 14525934 25348397 9278512 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CHEK2 RAD50 17525332 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CHEK2 FOXM1 25348397 N/A physical interaction ComPPI
CHEK2 REV3L 25348397 N/A physical interaction ComPPI
CHEK2 TP53 10724175 14525934 15862297 17157788 18833288 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay ComPPI,HPRD,IntAct
CHEK2 PPP2R2B 14525934 16596250 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CHEK2 ELAVL1 25348397 N/A physical interaction ComPPI
CHEK2 PSME3 25348397 N/A physical interaction ComPPI
CHEK2 LATS2 25348397 N/A physical interaction ComPPI
CHEK2 PML 25348397 N/A physical interaction ComPPI
CHEK2 APP 25348397 N/A physical interaction ComPPI
CHEK2 STRAP 18833288 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CHEK2 RCHY1 25348397 N/A physical interaction ComPPI
CHEK2 SIRT1 25348397 N/A physical interaction ComPPI
CHEK2 CCAR2 25348397 N/A physical interaction ComPPI
CHEK2 ILKAP 25348397 N/A physical interaction ComPPI
CHEK2 CDH13 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 CYP17A1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 DIRAS3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 HOXC6 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 IL24 24234451 25348397 25640309 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 ITIH5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 KLK7 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 KLK9 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 LYPD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 RHOBTB2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 ST14 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 NSD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 BAALC 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 GNAS 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 GNAS 25348397 N/A physical interaction ComPPI
CHEK2 GNAS 25348397 N/A physical interaction ComPPI
CHEK2 HMGN1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 STMN1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 TLR3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CHEK2 SRPK2 25348397 N/A physical interaction ComPPI
CHEK2 FOS 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CHEK2 AP5Z1 25348397 N/A physical interaction ComPPI
CHEK2 FOXK1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CHEK2 FOXK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CHEK2 TP63 25348397 N/A physical interaction ComPPI
CHEK2 PPM1D 25348397 N/A physical interaction ComPPI
CHEK2 PCBP2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 EIF3A 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 SMC2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 FARSA 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 FBXO22 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 PPM1G 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 RBM25 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 SF3B3 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 UBR4 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 CDK11A 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 LRRC8A 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 TARDBP 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 UBE2O 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 PUF60 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 EFTUD2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 HNRNPAB 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 EEF1G 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 MCM3 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 SMC4 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 SMC3 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 MCM7 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 SF3B2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CHEK2 PAICS 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PLK3 CHEK2 10973490 11901158 12242661 12493754 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PPP2R5D CHEK2 14525934 15380617 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
MUS81 CHEK2 11073977 11741546 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
EEF1D CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
GINS2 CHEK2 17525332 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF20 CHEK2 24234451 25348397 25640309 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TSSK1B CHEK2 12556502 14525934 N/A experimental interaction detection HPRD
CHEK2 CHEK2 16794575 18239682 24234451 phosphorylation reaction cross-linking study,x-ray crystallography,protein kinase assay IntAct
CDC7 CHEK2 18372119 20733106 23564203 27898060 N/A N/A OmniPath
CHEK2 PIN4 15024067 27898060 N/A N/A OmniPath
CHEK2 TERF2 19375317 27898060 inhibition,stimulant N/A OmniPath
TERF2 CHEK2 19375317 27898060 inhibition N/A OmniPath
CHEK2 CDC25A 10724175 11298456 12110582 12399544 12676583 12759351 14559997 14681206 18285803 18480045 27898060 inhibition N/A OmniPath
PLK1 CHEK2 10973490 11901158 12024051 12242661 12493754 20126263 27898060 inhibition,stimulant N/A OmniPath
CHEK2 BDNF 23712400 27898060 N/A N/A OmniPath
CHEK2 TTK 15618221 19151762 27898060 stimulant N/A OmniPath
TTK CHEK2 15618221 19151762 27898060 stimulant N/A OmniPath
CHEK2 RB1 17380128 22184068 27898060 stimulant N/A OmniPath
CHEK2 ELAVL1 17317627 19322201 21745814 21862584 24968827 27898060 stimulant N/A OmniPath
CHEK2 MDM2 10710310 15862297 16943424 19176998 27898060 inhibition,stimulant N/A OmniPath
PLK3 CHEK2 10973490 11901158 12242661 12493754 16481012 17918214 27898060 stimulant N/A OmniPath
CHEK2 STRAP 18833288 27898060 stimulant N/A OmniPath
CHEK2 KIT 22558186 27898060 stimulant N/A OmniPath
ATR CHEK2 10973490 11025670 11085506 11668173 11715017 11901158 12024051 12386164 12493754 12607004 12855706 15361851 16150728 16798742 16982735 17035231 21765476 27898060 9857181 stimulant N/A OmniPath
ATM CHEK2 10713094 10744722 10973490 11901158 12024051 12242661 12493754 12773400 15064416 15342622 15790808 16311512 16481012 16794575 17715138 27898060 9889122 stimulant N/A OmniPath
CHEK2 PML 12402044 27898060 N/A N/A OmniPath
CHEK2 REV3L 18622427 27898060 N/A N/A OmniPath
CHEK2 CDC25C 10557092 10681541 10744722 11333986 11438675 11551930 12024051 12402044 12835754 12909615 16705183 20068231 25361978 27898060 9278512 9543386 9836640 inhibition,stimulant N/A OmniPath
KPNA2 CHEK2 12909615 27898060 stimulant N/A OmniPath
CHEK2 TRIM28 18578522 22491012 22715096 23645696 24711418 25189701 26505995 27898060 N/A N/A OmniPath
CHEK2 TP53 10570149 10656682 10673501 10710310 10724175 10801407 11447225 11551930 12781359 12810724 15659650 15862297 17157788 17339337 18319725 18833288 20041275 27898060 9733514 9733515 9843217 inhibition,stimulant N/A OmniPath
PPM1D CHEK2 16311512 16936775 20599567 27898060 inhibition,stimulant N/A OmniPath
CHEK2 E2F1 12717439 20603083 22558186 27898060 stimulant N/A OmniPath
CHEK2 CDK11B 23178491 27898060 N/A N/A OmniPath
CHEK2 E2F3 19917728 27898060 N/A N/A OmniPath
CHEK2 ASF1A 11172707 11985607 27898060 inhibition N/A OmniPath
CHEK2 VHL 22071692 27898060 stimulant N/A OmniPath
CHEK2 BRCA1 10724175 12111733 12438214 14701743 17380128 18804494 20364141 27898060 stimulant N/A OmniPath
CHEK2 LATS2 21118956 27898060 N/A N/A OmniPath
PPP2CA CHEK2 15380617 16596250 27898060 stimulant N/A OmniPath
CSNK2B CHEK2 15940255 27898060 inhibition N/A OmniPath
CHEK2 MAPT 14517247 15576491 15652175 16386371 17045592 17482548 18424437 20067632 21215781 22033876 23001711 24618580 27898060 8999860 9735171 9801171 inhibition N/A OmniPath
CHEK2 XRCC1 18971944 27898060 stimulant N/A OmniPath
CHEK2 PPP2R5C 15380617 27898060 stimulant N/A OmniPath
CHEK2 BRCA2 14623252 17525332 18317453 27898060 N/A N/A OmniPath
CHEK2 MDM4 16163388 16511560 16511572 18356162 27898060 inhibition,stimulant N/A OmniPath
CHEK2 PTTG1 16647857 27898060 stimulant N/A OmniPath
PRKDC CHEK2 11390408 12805407 15668230 18644861 20713355 27898060 stimulant N/A OmniPath
CHEK2 FOXM1 17101782 27898060 stimulant N/A OmniPath
CHEK2 PSME3 19556897 25361978 27898060 N/A N/A OmniPath
MAP3K20 CHEK2 15342622 16311512 16481012 27898060 N/A N/A OmniPath
CHEK2 RASGRF1 17110335 27898060 inhibition N/A OmniPath
PPP2CB CHEK2 15380617 16596250 27898060 stimulant N/A OmniPath
CHEK2 AATF 17157788 27898060 N/A N/A OmniPath

Visualization










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