GENE：DAPK2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DAPK2 |
| FullNmae | death associated protein kinase 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2675 |
| EnsembleID | ENSG00000035664 |
| Uniprot | Q9UIK4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DAPK2 | autophagy | 34422995 | Mechanistically, DAPK2 promoted autophagy as demonstrated by the accumulation of microtubule-associated protein 1A/1B-light chain 3 (LC3)-II, which correlated with the level of nuclear factor-κB (NF-κB) activation. | retulator signature |
| DAPK2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| DAPK2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DAPK2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| DAPK2 | anoikis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DAPK2 | cuproptosis | 36072790 | CYP2D6,聽DAPK2,聽BCL2,聽RANTES, and聽IL-8聽are all related to the redox characteristics of copper. | redox characteristics of copper |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DAPK2 | GO:0004674,GO:0004674,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005794,GO:0006468,GO:0006915,GO:0010506,GO:0031410,GO:0034423,GO:0035556,GO:0035556,GO:0042802,GO:0042981,GO:0043065,GO:0043231,GO:0043276,GO:0046777,GO:0090023,GO:0106310,GO:2000424,GO:2001242 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DAPK2 | hsa:23604 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| DAPK2 | hsa:23604 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| DAPK2 | hsa:23604 | path:hsa05219 | Bladder cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DAPK2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | DAPK2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | DAPK2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | DAPK2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | DAPK2 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | DAPK2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | DAPK2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | DAPK2 | 18971253 24038216 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DAPK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | DAPK2 | 18521079 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KLF6 | DAPK2 | 18521079 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | DAPK2 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000020CEC2 | DAPK2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | DAPK2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075E2C3 | DAPK2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000358C16 | DAPK2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | DAPK2 | 25416803 27049921 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RACGAP1 | DAPK2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KLC3 | DAPK2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DAPK2 | APP | 25348397 | N/A | physical interaction | ComPPI |
| DAPK2 | FAM9B | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| DAPK2 | LLGL2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DAPK2 | TUBGCP5 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DAPK2 | TGFBR1 | 14525934 15761153 | N/A | experimental interaction detection | HPRD |
| CTNNB1 | DAPK2 | 18957423 27898060 | inhibition | N/A | OmniPath |
| EPO | DAPK2 | 18535204 27898060 | stimulant | N/A | OmniPath |
| E2F1 | DAPK2 | 18521079 27898060 | stimulant | N/A | OmniPath |
| KLF6 | DAPK2 | 18521079 27898060 | stimulant | N/A | OmniPath |
| DAPK2 | MYL1 | 11313698 27898060 | stimulant | N/A | OmniPath |