Gene Information gene info

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GENE：ITGA5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGA5
FullNmae integrin subunit alpha 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6141
EnsembleID ENSG00000161638
Uniprot P08648

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGA5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGA5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGA5 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGA5 anoikis 25537511 Through gain- and loss-of-function studies, we demonstrate that ITGA5 is a functional target of miR-26a-induced anoikis in HCC cells. retulator signature

Go Annotation:

GeneSymbol Go id
ITGA5 GO:0001525,GO:0001525,GO:0001618,GO:0001726,GO:0005154,GO:0005161,GO:0005178,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0005911,GO:0005925,GO:0005925,GO:0007044,GO:0007155,GO:0007157,GO:0007159,GO:0007160,GO:0007160,GO:0007229,GO:0007229,GO:0007229,GO:0007565,GO:0007613,GO:0008305,GO:0009897,GO:0009986,GO:0009986,GO:0010811,GO:0023035,GO:0030335,GO:0030949,GO:0031410,GO:0031589,GO:0032587,GO:0033627,GO:0033627,GO:0033631,GO:0034113,GO:0034674,GO:0034674,GO:0035313,GO:0035313,GO:0035987,GO:0043184,GO:0045211,GO:0046718,GO:0046872,GO:0050731,GO:0071062,GO:0098609,GO:0098978,GO:1903672,GO:2000811

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGA5 hsa:3678 path:hsa03266 Virion - Herpesvirus - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa04145 Phagosome - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa04510 Focal adhesion - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05131 Shigellosis - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05133 Pertussis - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05135 Yersinia infection - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ITGA5 hsa:3678 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGB1 ITGA5 10461188 10545505 10559936 10613909 11340065 11413130 11950587 12731048 15866889 16076871 16919435 17522712 18037882 19161977 19339212 19454690 19487819 20644254 20814939 22067905 22154077 22470492 24202395 26192618 7529872 7657702 9003039 9456329 9763606 9973479 association N/A ACSN
ITGA5 FN1 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 26192618 9003039 9456329 9763606 9973479 interaction type N/A ACSN
RAB21 ITGA5 19953096 26192618 interaction type N/A ACSN
POSTN ITGA5 20096135 22158103 26192618 interaction type N/A ACSN
ARF1 ITGA5 22595524 23691193 24376839 26192618 interaction type N/A ACSN
PTP4A3 ITGA5 22595524 23691193 24376839 26192618 interaction type N/A ACSN
ITGA5 ZAP70 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 26192618 9003039 9456329 9763606 9973479 interaction type N/A ACSN
ITGA5 FYN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 26192618 9003039 9456329 9763606 9973479 interaction type N/A ACSN
ITGA5 CD40LG 17182621 23180781 physical association solid phase assay InnateDB
ITGA5 LGALS8 16368432 18024965 18849583 23180781 physical association pull down InnateDB
LGALS9 ITGA5 18024965 23180781 physical association pull down InnateDB
ITGA5 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGA5 CXCR4 17077324 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GIPC1 ITGA5 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR ITGA5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ITGA5 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ITGA5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ITGA5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ITGA5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 ITGA5 18775869 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SP3 ITGA5 18775869 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
PRDM14 ITGA5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITGA5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HOXD3 ITGA5 14610084 trascriptional regulation,stimulation inferred by curator TFlink
NFIC ITGA5 18775869 trascriptional regulation,stimulation inferred by curator TFlink
PAX6 ITGA5 10954416 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ITGA5 18775869 trascriptional regulation,stimulation inferred by curator TFlink
ZEB2 ITGA5 22227038 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITGA5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000521626 ITGA5 23238785 rna interference,inhibition western blot miRSponge
URS0000001EB3 ITGA5 19524507 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 ITGA5 19524507 25416803 26729197 27050274 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000521626 ITGA5 23233531 23238785 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000122ED0 ITGA5 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE ITGA5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB ITGA5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000C73C ITGA5 23238588 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BBF48 ITGA5 21703006 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000016914 ITGA5 24434435 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001DE669 ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6EFA ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004A9320 ITGA5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ITGA5 25416803 27499367 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007A060 ITGA5 25416803 28336765 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ITGA5 ITGB5 25361965 interaction type N/A PTMCode2
ITGB5 ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 ILK 25361965 interaction type N/A PTMCode2
ILK ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 GIPC1 25361965 interaction type N/A PTMCode2
GIPC1 ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 MMP9 25361965 interaction type N/A PTMCode2
MMP9 ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 ITGB1 25361965 interaction type N/A PTMCode2
ITGB1 ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 SPP1 25361965 interaction type N/A PTMCode2
SPP1 ITGA5 25361965 interaction type N/A PTMCode2
TNC ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 TNC 25361965 interaction type N/A PTMCode2
ITGB3 ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 ITGB3 25361965 interaction type N/A PTMCode2
FLT4 ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 FLT4 25361965 interaction type N/A PTMCode2
COL1A1 ITGA5 25361965 interaction type N/A PTMCode2
ITGA5 COL1A1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RABIF ITGA5 25348397 N/A physical interaction ComPPI
FABP3 ITGA5 20802519 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
ITGB5 ITGA5 25348397 N/A physical interaction,in vitro,in vivo ComPPI
TAFA4 ITGA5 25348397 N/A physical interaction ComPPI
ERBB2 ITGA5 25348397 N/A in vivo ComPPI
ARHGAP5 ITGA5 25348397 N/A in vivo ComPPI
CBL ITGA5 25348397 N/A physical interaction ComPPI
PECAM1 ITGA5 25348397 N/A in vivo ComPPI
CD81 ITGA5 24234451 25348397 30024968 association anti bait coimmunoprecipitation ComPPI,IntAct
CD9 ITGA5 25348397 N/A physical interaction,in vivo ComPPI
FGFR2 ITGA5 25348397 N/A physical interaction,in vitro ComPPI
ITGB1 ITGA5 12724312 16099422 21947080 22178926 24234451 25348397 30021884 association,physical association anti bait coimmunoprecipitation,cross-linking study,pull down,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,IntAct
SPP1 ITGA5 25348397 N/A in vitro ComPPI
CIB1 ITGA5 25348397 N/A physical interaction ComPPI
UBC ITGA5 25348397 N/A physical interaction ComPPI
ITGB3 ITGA5 25348397 N/A physical interaction,in vitro ComPPI
TLN1 ITGA5 25348397 N/A physical interaction ComPPI
ILK ITGA5 25348397 N/A physical interaction ComPPI
ANGPTL3 ITGA5 25348397 N/A in vitro ComPPI
L1CAM ITGA5 25348397 N/A physical interaction,in vitro ComPPI
HNRNPU ITGA5 25348397 N/A physical interaction ComPPI
CLK1 ITGA5 25348397 N/A physical interaction ComPPI
CCN2 ITGA5 16457822 24234451 25348397 colocalization imaging technique ComPPI,IntAct
EWSR1 ITGA5 25348397 N/A physical interaction ComPPI
GIPC1 ITGA5 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
GRK6 ITGA5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATP1A1 ITGA5 25348397 N/A physical interaction ComPPI
EGFR ITGA5 25348397 N/A in vitro,in vivo ComPPI
FLT4 ITGA5 25348397 N/A in vitro ComPPI
FUBP1 ITGA5 25348397 N/A physical interaction ComPPI
ADAM15 ITGA5 24234451 24789099 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
ACVRL1 ITGA5 22940691 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
VCAM1 ITGA5 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
AUP1 ITGA5 25348397 N/A two hybrid,physical interaction ComPPI
LGALS8 ITGA5 25348397 N/A physical interaction ComPPI
NISCH ITGA5 25348397 N/A in vitro,in vivo ComPPI
ANGPT1 ITGA5 25348397 N/A in vitro ComPPI
ANGPT2 ITGA5 25348397 N/A physical interaction ComPPI
ENG ITGA5 22940691 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
COL1A1 ITGA5 25348397 N/A in vitro,in vivo ComPPI
STAMBP ITGA5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CX3CL1 ITGA5 23125415 24234451 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
MMP9 ITGA5 12724312 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SHARPIN ITGA5 21947080 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,physical interaction ComPPI,IntAct
CTDSPL ITGA5 25348397 N/A physical interaction ComPPI
COL18A1 ITGA5 25348397 N/A in vivo ComPPI
ITGA5 FN1 16457822 19738201 24234451 24789099 25348397 colocalization,association,physical association cross-linking study,fluorescence-activated cell sorting,physical interaction,imaging technique ComPPI,IntAct
ITGA5 FBXO6 25348397 N/A physical interaction ComPPI
ITGA5 SEL1L 25348397 N/A physical interaction ComPPI
ITGA5 ATP1B3 25348397 N/A physical interaction ComPPI
ITGA5 LGALS3BP 25348397 N/A physical interaction ComPPI
ITGA5 UBAP1 25348397 N/A physical interaction ComPPI
ITGA5 BTNL3 25348397 N/A physical interaction ComPPI
ITGA5 ADAM32 25348397 N/A physical interaction ComPPI
ITGA5 NRP1 19175293 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGA5 PLPP3 16099422 24234451 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
ITGA5 TGFBR1 22940691 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ITGA5 FGG 24234451 24789099 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
ITGA5 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GPR182 ITGA5 24234451 28298427 physical association ubiquitin reconstruction IntAct
ITGA5 CD40LG 17182621 27898060 N/A N/A OmniPath
CXCR4 ITGA5 17077324 27898060 N/A N/A OmniPath
ITGB1 ITGA5 10772816 12883474 20643357 21947080 22939629 26344197 27898060 7504269 N/A N/A OmniPath
FN1 ITGA5 10772816 11801679 1532572 16457822 1694173 17015452 18480047 19738201 20643357 22451694 26456826 27898060 6325925 9211865 stimulant N/A OmniPath
GIPC1 ITGA5 11479315 11852236 27898060 N/A N/A OmniPath
ITGA5 SDC2 10772816 27898060 N/A N/A OmniPath
SDC2 ITGA5 10772816 27898060 N/A N/A OmniPath
FGG ITGA5 15031111 27898060 N/A N/A OmniPath
ITGA5 ITGB6 1532572 27898060 N/A N/A OmniPath
FGA ITGA5 15031111 27898060 N/A N/A OmniPath
ITGA5 ITGB3 1694173 22470492 26344197 27898060 9516430 9914169 N/A N/A OmniPath
FBN1 ITGA5 20686071 27898060 N/A N/A OmniPath
CCN2 ITGA5 16457822 18167060 27898060 N/A N/A OmniPath
FGB ITGA5 15031111 27898060 N/A N/A OmniPath

Visualization










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