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GENE：SNAI2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SNAI2
FullNmae snail family transcriptional repressor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11094
EnsembleID ENSG00000019549
Uniprot O43623

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SNAI2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SNAI2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SNAI2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SNAI2 anoikis 36726781 Four anoikis-related genes(SNAI2, TFDP1, IKBKG, and MCL1) with significant differential expression were selected through Cox regression and LASSO analyses. retulator signature

Go Annotation:

GeneSymbol Go id
SNAI2 GO:0000122,GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001649,GO:0001837,GO:0003180,GO:0003198,GO:0003198,GO:0003273,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006325,GO:0006355,GO:0006933,GO:0007219,GO:0007605,GO:0010839,GO:0010957,GO:0014032,GO:0030335,GO:0032331,GO:0032642,GO:0033028,GO:0033033,GO:0033629,GO:0035921,GO:0043473,GO:0043518,GO:0043542,GO:0043565,GO:0045600,GO:0045667,GO:0046872,GO:0050872,GO:0060021,GO:0060429,GO:0060536,GO:0060693,GO:0061314,GO:0070563,GO:0070888,GO:0071364,GO:0071425,GO:0071479,GO:0090090,GO:0090090,GO:1902034,GO:1902230,GO:1990837,GO:2000810,GO:2000811,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SNAI2 hsa:6591 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
SNAI2 hsa:6591 path:hsa04520 Adherens junction - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SNAI2 MDM2 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 26192618 6396087 9450543 9618481 interaction type N/A ACSN
HDAC1 SNAI2 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 26192618 9618481 interaction type N/A ACSN
HDAC3 SNAI2 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 26192618 9618481 interaction type N/A ACSN
SMAD4 SNAI2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
SNAI1 SNAI2 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 26192618 8844971 9157999 9618481 interaction type N/A ACSN
TWIST1 SNAI2 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21502402 21733352 2191300 21919891 22406545 22945800 26192618 7768934 9278421 interaction type N/A ACSN
HMGA2 SNAI2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
KITLG SNAI2 12490555 14623871 15099563 15337769 16510505 16831886 17093497 17550342 18524989 18633355 18832382 20731704 21199805 21317430 22406545 26192618 interaction type N/A ACSN
KIT SNAI2 12490555 14623871 15099563 15337769 16510505 16831886 17093497 17550342 18524989 18633355 18832382 20731704 21199805 21317430 22406545 26192618 interaction type N/A ACSN
SNAI2 TCF3 12490555 12668723 14623871 15140942 15151915 15574337 16232121 16510505 16831886 17093497 17550342 18832382 19448627 20731704 21051859 21199805 21317430 22370643 22406545 26192618 interaction type N/A ACSN
SNAI2 BMI1 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 26192618 9618481 interaction type N/A ACSN
SNAI2 HDAC2 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 26192618 9618481 interaction type N/A ACSN
SNAI2 SIN3A 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 26192618 9618481 interaction type N/A ACSN
SNAI2 SSX7 16849535 23180781 physical association anti tag coimmunoprecipitation InnateDB
SNAI2 CDH1 16849535 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRIM23 SNAI2 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR SNAI2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 SNAI2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SNAI2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 SNAI2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SNAI2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 SNAI2 15955695 trascriptional regulation,stimulation inferred by curator TFlink
ESRRA SNAI2 15955695 trascriptional regulation,stimulation inferred by curator TFlink
EZH2 SNAI2 23836662 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 SNAI2 18588516 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 SNAI2 23836662 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 SNAI2 20128911 trascriptional regulation,stimulation inferred by curator TFlink
MTA1 SNAI2 18719363 trascriptional regulation,stimulation inferred by curator TFlink
NCOR1 SNAI2 18588516 trascriptional regulation,stimulation inferred by curator TFlink
PER2 SNAI2 23836662 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 SNAI2 23836662 trascriptional regulation,stimulation inferred by curator TFlink
RUNX2 SNAI2 22641097 trascriptional regulation,stimulation inferred by curator TFlink
SUZ12 SNAI2 23836662 trascriptional regulation,stimulation inferred by curator TFlink
TCF7 SNAI2 20128911 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 SNAI2 20128911 trascriptional regulation,stimulation inferred by curator TFlink
WT1 SNAI2 17430890 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001CC379 SNAI2 23354685 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB SNAI2 23354685 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 SNAI2 20056717 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00002E1509 SNAI2 23434592 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 SNAI2 20056717 23824327 25416803 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS00001CC379 SNAI2 23354685 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004DA9DB SNAI2 23354685 25416803 25871397 26194864 28269747 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002E1509 SNAI2 23434592 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000521626 SNAI2 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00004AE8D3 SNAI2 23717581 25416803 25707493 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000345DEB SNAI2 24277930 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016FF9C SNAI2 24277930 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000043D2C1 SNAI2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 SNAI2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 SNAI2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SNAI2 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 SNAI2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 SNAI2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000009C45F SNAI2 25416803 26918943 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000007D64A SNAI2 25416803 26700673 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B SNAI2 22135298 phosphorylation N/A PhosphoSite
MAPK1 SNAI2 22135298 phosphorylation N/A PhosphoSite
PAK1 SNAI2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
DAXX SNAI2 25348397 N/A physical interaction ComPPI
SAT1 SNAI2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNAI2 HDAC2 25348397 N/A physical interaction ComPPI
SNAI2 HDAC1 25348397 N/A physical interaction ComPPI
SNAI2 GSK3B 25348397 N/A physical interaction ComPPI
SNAI2 KDM1A 25348397 N/A physical interaction ComPPI
SNAI2 CHD4 25348397 N/A physical interaction ComPPI
SNAI2 APP 25348397 N/A physical interaction ComPPI
SNAI2 MDM2 25348397 N/A physical interaction ComPPI
SNAI2 TP53 25348397 N/A physical interaction ComPPI
SNAI2 TJP2 25348397 N/A physical interaction ComPPI
SNAI2 PSMD1 25348397 N/A physical interaction ComPPI
SNAI2 PPP2CB 25348397 N/A physical interaction ComPPI
SNAI2 PSMD3 25348397 N/A physical interaction ComPPI
SNAI2 PSMA3 25348397 N/A physical interaction ComPPI
SNAI2 PPP6R3 25348397 N/A physical interaction ComPPI
SNAI2 STUB1 25348397 N/A physical interaction ComPPI
SNAI2 PPP2R2D 25348397 N/A physical interaction ComPPI
SNAI2 PSMC1 25348397 N/A physical interaction ComPPI
SNAI2 TRIM23 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNAI2 NXF1 25348397 N/A physical interaction ComPPI
SNAI2 USP17L2 25348397 N/A physical interaction ComPPI
SNAI2 FBXO31 25348397 N/A physical interaction ComPPI
SNAI2 ZNF76 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNAI2 CSNK2A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNAI2 CABP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK1 SNAI2 25855378 27898060 N/A N/A OmniPath
GSK3B SNAI2 22727060 23011797 23851495 27898060 N/A N/A OmniPath

Visualization










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