GENE：ACKR3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACKR3 |
| FullNmae | atypical chemokine receptor 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:23692 |
| EnsembleID | ENSG00000144476 |
| Uniprot | P25106 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACKR3 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ACKR3 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ACKR3 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACKR3 | GO:0001525,GO:0001570,GO:0005044,GO:0005515,GO:0005768,GO:0005769,GO:0005886,GO:0005886,GO:0005905,GO:0006955,GO:0007155,GO:0007186,GO:0007204,GO:0008285,GO:0009897,GO:0009986,GO:0015026,GO:0016493,GO:0016494,GO:0019722,GO:0019957,GO:0019958,GO:0021557,GO:0031623,GO:0043231,GO:0055037,GO:0060326,GO:0070098,GO:0070374,GO:1902230,GO:1905322 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACKR3 | hsa:57007 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| ACKR3 | hsa:57007 | path:hsa04061 | Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | ACKR3 | 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| ETS1 | ACKR3 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | ACKR3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | ACKR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIC1 | ACKR3 | 19525223 23340301 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | ACKR3 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000122ED0 | ACKR3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001A405B | ACKR3 | 25416803 27035873 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ATP5PO | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ATP5F1B | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PECAM1 | ACKR3 | 24234451 24497640 25348397 | physical association | proximity ligation assay | ComPPI,IntAct |
| GRB2 | ACKR3 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| HNRNPL | ACKR3 | 25348397 | N/A | physical interaction | ComPPI |
| ATP5F1A | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL4 | ACKR3 | 25348397 | N/A | physical interaction | ComPPI |
| GJB2 | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ATP5PD | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TP53 | ACKR3 | 25348397 | N/A | physical interaction | ComPPI |
| UBR7 | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ESPL1 | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CD164 | ACKR3 | 24094005 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ATP13A2 | ACKR3 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| HECTD2 | ACKR3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ATP5F1D | ACKR3 | 25348397 | N/A | physical interaction | ComPPI |
| CXCL12 | ACKR3 | 16107333 20956518 23396314 27898060 | stimulant | N/A | OmniPath |