GENE：ADORA1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ADORA1 |
| FullNmae | adenosine A1 receptor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:262 |
| EnsembleID | ENSG00000163485 |
| Uniprot | P30542 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ADORA1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ADORA1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ADORA1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ADORA1 | GO:0001609,GO:0001659,GO:0001664,GO:0001666,GO:0001883,GO:0001973,GO:0002087,GO:0002674,GO:0002686,GO:0002793,GO:0003084,GO:0003085,GO:0003093,GO:0005515,GO:0005886,GO:0005886,GO:0006612,GO:0006909,GO:0006954,GO:0007165,GO:0007186,GO:0007193,GO:0007267,GO:0007399,GO:0008285,GO:0010035,GO:0014050,GO:0014074,GO:0016042,GO:0016323,GO:0030425,GO:0030673,GO:0031072,GO:0031683,GO:0032229,GO:0032244,GO:0032279,GO:0032795,GO:0032900,GO:0035307,GO:0042311,GO:0042323,GO:0042734,GO:0043025,GO:0043066,GO:0043195,GO:0043197,GO:0043268,GO:0043410,GO:0044305,GO:0045202,GO:0045211,GO:0046888,GO:0046982,GO:0048786,GO:0050890,GO:0050900,GO:0050965,GO:0050995,GO:0050996,GO:0051930,GO:0051967,GO:0055089,GO:0060079,GO:0060292,GO:0070254,GO:0070256,GO:0070328,GO:0086004,GO:0097190,GO:0099509,GO:1900272,GO:1900453 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ADORA1 | hsa:134 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| ADORA1 | hsa:134 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| ADORA1 | hsa:134 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| ADORA1 | hsa:134 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| ADORA1 | hsa:134 | path:hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| ADORA1 | hsa:134 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
| ADORA1 | hsa:134 | path:hsa05032 | Morphine addiction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ADORA1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | ADORA1 | 18414489 19376833 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| ESR2 | ADORA1 | 19376833 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ADORA1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | ADORA1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ADORA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ADORA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ADORA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ADORA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ADORA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | ADORA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ADORA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | ADORA1 | 9547356 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | ADORA1 | 9547356 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ADORA1 | GNAI1 | 25361965 | interaction type | N/A | PTMCode2 |
| GNAI1 | ADORA1 | 25361965 | interaction type | N/A | PTMCode2 |
| GRM1 | ADORA1 | 25361965 | interaction type | N/A | PTMCode2 |
| ADORA1 | GRM1 | 25361965 | interaction type | N/A | PTMCode2 |
| GNAO1 | ADORA1 | 25361965 | interaction type | N/A | PTMCode2 |
| ADORA1 | GNAO1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GRM1 | ADORA1 | 11278325 25348397 27898060 | N/A | physical interaction,in vitro | ComPPI,OmniPath |
| ADORA2A | ADORA1 | 16481441 24234451 25348397 27898060 | colocalization,physical association | anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,confocal microscopy | ComPPI,IntAct,OmniPath |
| EPB41L2 | ADORA1 | 12974671 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| SNF8 | ADORA1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| GNAS | ADORA1 | 10521440 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| P2RY1 | ADORA1 | 11390975 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| GNAI2 | ADORA1 | 11369591 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| GNAO1 | ADORA1 | 10521440 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| GNAZ | ADORA1 | 14525934 25348397 9166747 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| DRD1 | ADORA1 | 10890919 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| ADORA1 | ADA | 12150791 14525934 25348397 27898060 9247966 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| ADORA1 | ATXN1L | 25348397 | N/A | physical interaction | ComPPI |
| ADORA1 | TSHR | 24234451 28298427 | physical association | anti tag coimmunoprecipitation,ubiquitin reconstruction | IntAct |
| ADORA1 | GNAI3 | 27898060 3805010 6162091 6305455 | stimulant | N/A | OmniPath |