Gene Information gene info

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GENE：AEN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AEN
FullNmae apoptosis enhancing nuclease
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25722
EnsembleID ENSG00000181026
Uniprot Q8WTP8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AEN parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AEN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AEN apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AEN apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
AEN GO:0003676,GO:0004527,GO:0004527,GO:0004529,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006259,GO:0010212,GO:0031965,GO:0042771,GO:0042771

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AEN AAMP 23180781 25416956 physical association two hybrid InnateDB
TLE5 AEN 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 AEN 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 AEN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 AEN 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 AEN 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 AEN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 AEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 AEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 AEN 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 AEN 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AA464 AEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000355E82 AEN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 AEN 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000279B6F AEN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 AEN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 AEN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 AEN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA AEN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075E538 AEN 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 AEN 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F AEN 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E AEN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F AEN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 AEN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 AEN 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PDE4DIP AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZBTB8A AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-5 AEN 24234451 25348397 25416956 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZBTB43 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-1 AEN 25348397 N/A physical interaction ComPPI
KRTAP10-8 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LZTS2 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-7 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EMD AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TP53BP1 AEN 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
KHDRBS2 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT40 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PHC2 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZNF473 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EXOSC8 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKN1 AEN 25348397 N/A physical interaction ComPPI
TLE5 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SSX2IP AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MID2 AEN 25348397 N/A physical interaction ComPPI
RBMY1A1 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
IKZF1 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRIP2 AEN 25348397 N/A physical interaction ComPPI
NKX3-1 AEN 25348397 N/A physical interaction ComPPI
SEMA4B AEN 25348397 N/A physical interaction ComPPI
TRIM27 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PPID AEN 25348397 N/A physical interaction ComPPI
RPGRIP1 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RALYL AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZFP64 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM41 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MTUS2 AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AAMP AEN 25348397 N/A physical interaction ComPPI
HOMEZ AEN 25348397 N/A physical interaction ComPPI
GNPTAB AEN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MBNL1 AEN 25348397 N/A physical interaction ComPPI
AEN ZNF317 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AEN RBMY1F 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AEN KRTAP10-3 25348397 N/A physical interaction ComPPI

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