GENE：AGT
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AGT |
| FullNmae | angiotensinogen |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:333 |
| EnsembleID | ENSG00000135744 |
| Uniprot | P01019 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AGT | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AGT | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AGT | GO:0001558,GO:0001819,GO:0001822,GO:0001974,GO:0002016,GO:0002018,GO:0002019,GO:0002034,GO:0002034,GO:0003014,GO:0004867,GO:0005179,GO:0005179,GO:0005179,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005615,GO:0005615,GO:0005829,GO:0007186,GO:0007199,GO:0007200,GO:0007263,GO:0007267,GO:0008083,GO:0008217,GO:0010536,GO:0010595,GO:0010613,GO:0010718,GO:0010744,GO:0014873,GO:0019229,GO:0031702,GO:0031703,GO:0033864,GO:0034374,GO:0035813,GO:0038166,GO:0042127,GO:0042310,GO:0042981,GO:0043407,GO:0045742,GO:0045893,GO:0048146,GO:0050729,GO:0050731,GO:0051092,GO:0051247,GO:0051387,GO:0051897,GO:0061098,GO:0062023,GO:0070062,GO:0072562,GO:0090190,GO:1901201,GO:1901394,GO:1903598,GO:1903779,GO:1905920,GO:2000379,GO:2001238 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AGT | hsa:183 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04614 | Renin-angiotensin system - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04931 | Insulin resistance - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
| AGT | hsa:183 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| STAT1 | AGT | 11222715 23180781 | physical association | affinity chromatography technology | InnateDB |
| STAT3 | AGT | 11222715 23180781 | physical association | affinity chromatography technology | InnateDB |
| REN | AGT | 20927107 23180781 | physical association | x-ray crystallography | InnateDB |
| AGT | ACE2 | 10969042 23180781 | cleavage reaction | cleavage assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NFKB1 | AGT | 10628750 8613256 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| YBX1 | AGT | 11829142 19151767 | trascriptional regulation,stimulation | affinity blotting,inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| HNF1A | AGT | 17475670 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | AGT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AGT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AGT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AGT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | AGT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | AGT | 10628750 8613256 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | AGT | 12032593 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | AGT | 12032593 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | AGT | 18802024 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF1 | AGT | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | AGT | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ACE2 | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | ACE2 | 25361965 | interaction type | N/A | PTMCode2 |
| KNG1 | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | KNG1 | 25361965 | interaction type | N/A | PTMCode2 |
| CMA1 | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | CMA1 | 25361965 | interaction type | N/A | PTMCode2 |
| AGTR1 | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | AGTR1 | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | AGTR2 | 25361965 | interaction type | N/A | PTMCode2 |
| AGTR2 | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| CTSG | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | CTSG | 25361965 | interaction type | N/A | PTMCode2 |
| REN | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | REN | 25361965 | interaction type | N/A | PTMCode2 |
| MAS1 | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | MAS1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AGTR1 | AGT | 25348397 | N/A | in vivo | ComPPI |
| CTSG | AGT | 10899625 11747312 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GRB2 | AGT | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| CMA1 | AGT | 10899625 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MEP1A | AGT | 11278902 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CANX | AGT | 25348397 | N/A | physical interaction | ComPPI |
| KNG1 | AGT | 11677365 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| PRG2 | AGT | 14525934 25348397 27898060 7539791 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| HSPA5 | AGT | 25348397 | N/A | physical interaction | ComPPI |
| EWSR1 | AGT | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| REN | AGT | 20927107 24234451 25348397 | protein cleavage | x-ray crystallography,physical interaction,protease assay,protein cleavage | ComPPI,IntAct |
| ATP6AP2 | AGT | 25348397 | N/A | physical interaction | ComPPI |
| AGTR2 | AGT | 14525934 25348397 8185599 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MME | AGT | 25348397 | N/A | physical interaction | ComPPI |
| ACE2 | AGT | 10969042 11815627 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PREP | AGT | 12173 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ECE1 | AGT | 25348397 | N/A | physical interaction | ComPPI |
| PRCP | AGT | 14525934 25348397 27898060 28321 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| AGT | ENPEP | 14525934 1756856 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| AGT | MAS1 | 12829792 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| AGT | TP53 | 25348397 | N/A | physical interaction | ComPPI |
| AGT | ITSN2 | 25348397 | N/A | physical interaction | ComPPI |
| AGT | ACE | 25348397 | N/A | physical interaction | ComPPI |
| AGT | GSDMB | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| AGT | RIPK4 | 25348397 | N/A | physical interaction | ComPPI |
| AGT | NDUFA3 | 25348397 | N/A | physical interaction | ComPPI |
| DNPEP | AGT | 12895663 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| AGT | AGT | 11709400 14525934 1756856 | N/A | experimental interaction detection | HPRD |
| AGT | ANCE | 23082758 24234451 | cleavage reaction | x-ray crystallography,enzymatic study | IntAct |
| AGT | AGTR1 | 15930094 16597412 21464395 27898060 | stimulant | N/A | OmniPath |
| AGT | LRP2 | 15467006 27898060 | stimulant | N/A | OmniPath |
| ACE | AGT | 10969042 11076943 15283675 23056909 27898060 | stimulant | N/A | OmniPath |
| REN | AGT | 12045255 16816138 20927107 27898060 | stimulant | N/A | OmniPath |
| AGT | MAS1 | 12829792 27898060 | stimulant | N/A | OmniPath |