GENE：AGTR2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AGTR2 |
| FullNmae | angiotensin II receptor type 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:338 |
| EnsembleID | ENSG00000180772 |
| Uniprot | P50052 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AGTR2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AGTR2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AGTR2 | GO:0001974,GO:0001991,GO:0002033,GO:0002035,GO:0004945,GO:0004945,GO:0004945,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0006954,GO:0007166,GO:0007186,GO:0007186,GO:0007199,GO:0007263,GO:0007263,GO:0007420,GO:0008217,GO:0010459,GO:0030308,GO:0032516,GO:0035556,GO:0035566,GO:0035640,GO:0038166,GO:0042311,GO:0043537,GO:0045429,GO:0045893,GO:0048019,GO:0051000,GO:0051387,GO:0051402,GO:0072300,GO:0090190,GO:2001238 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AGTR2 | hsa:186 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| AGTR2 | hsa:186 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| AGTR2 | hsa:186 | path:hsa04614 | Renin-angiotensin system - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | AGTR2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| TP73 | AGTR2 | 19558638 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CTCF | AGTR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AGTR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETV4 | AGTR2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | AGTR2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000521626 | AGTR2 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001E0AEA | AGTR2 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000381CEC | AGTR2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F74F1 | AGTR2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ECEE4 | AGTR2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E628F | AGTR2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAI1 | AGTR2 | 25361965 | interaction type | N/A | PTMCode2 |
| AGTR2 | GNAI1 | 25361965 | interaction type | N/A | PTMCode2 |
| ACE | AGTR2 | 25361965 | interaction type | N/A | PTMCode2 |
| AGTR2 | ACE | 25361965 | interaction type | N/A | PTMCode2 |
| AGT | AGTR2 | 25361965 | interaction type | N/A | PTMCode2 |
| AGTR2 | AGT | 25361965 | interaction type | N/A | PTMCode2 |
| MTUS1 | AGTR2 | 25361965 | interaction type | N/A | PTMCode2 |
| AGTR2 | MTUS1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAI3 | AGTR2 | 11055978 14525934 25348397 8663053 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ERBIN | AGTR2 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CB | AGTR2 | 11459796 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| AGTRAP | AGTR2 | 25348397 | N/A | physical interaction | ComPPI |
| ZBTB16 | AGTR2 | 14525934 14657020 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD,OmniPath |
| TIMP3 | AGTR2 | 18344519 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| SNTA1 | AGTR2 | 25348397 | N/A | physical interaction | ComPPI |
| AGTR2 | MTUS1 | 14525934 15123706 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| AGTR2 | GNAI2 | 11055978 14525934 25348397 8663053 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| AGTR2 | AGT | 14525934 25348397 8185599 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| AGTR2 | ACE | 11459796 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| AGTR2 | ERBB3 | 10710290 14525934 | N/A | two hybrid | HPRD |
| AGTR2 | GNAQ | 11313903 27898060 | stimulant | N/A | OmniPath |
| TIMP3 | AGTR2 | 18344519 27898060 | N/A | N/A | OmniPath |
| ERBIN | AGTR2 | 15123239 27898060 | N/A | N/A | OmniPath |