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GENE：ATP2A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATP2A1
FullNmae ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:811
EnsembleID ENSG00000196296
Uniprot O14983

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATP2A1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATP2A1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATP2A1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATP2A1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATP2A1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATP2A1 GO:0005388,GO:0005388,GO:0005388,GO:0005509,GO:0005515,GO:0005524,GO:0005739,GO:0005789,GO:0006816,GO:0006874,GO:0008637,GO:0016020,GO:0016020,GO:0016529,GO:0016887,GO:0030899,GO:0031095,GO:0031448,GO:0032470,GO:0032471,GO:0033017,GO:0033017,GO:0033017,GO:0034220,GO:0034704,GO:0034976,GO:0042803,GO:0051561,GO:0051659,GO:0070059,GO:0070509,GO:0070588,GO:0090076,GO:0106134,GO:1901896,GO:1902082,GO:1903779,GO:1990036

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATP2A1 hsa:487 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04148 Efferocytosis - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
ATP2A1 hsa:487 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 ATP2A1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
CEBPA ATP2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ATP2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATP2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATP2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ATP2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
SLN ATP2A1 12032137 12692302 14525934 25348397 27898060 9575189 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
APPL1 ATP2A1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
H4C1 ATP2A1 25348397 N/A physical interaction ComPPI
TLE3 ATP2A1 25348397 N/A physical interaction ComPPI
SETDB1 ATP2A1 25348397 N/A physical interaction ComPPI
JUN ATP2A1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CUL3 ATP2A1 25348397 N/A physical interaction ComPPI
IRS2 ATP2A1 14525934 25348397 9295312 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PLN ATP2A1 10551848 11526231 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CFTR ATP2A1 25348397 N/A physical interaction ComPPI
HMGB1 ATP2A1 25348397 N/A physical interaction ComPPI
PDHA1 ATP2A1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IRS1 ATP2A1 14525934 25348397 9295312 N/A experimental interaction detection,in vivo ComPPI,HPRD
WWOX ATP2A1 25348397 N/A physical interaction ComPPI
TNFRSF1B ATP2A1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP2A1 PCK1 25348397 N/A physical interaction ComPPI
ATP2A1 ITPR3 25348397 N/A physical interaction ComPPI
ATP2A1 ATOH1 25348397 N/A physical interaction ComPPI
ATP2A1 VNN2 25348397 N/A physical interaction ComPPI
ATP2A1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP2A1 TULP3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
CCR8 ATP2A1 24234451 28298427 physical association ubiquitin reconstruction IntAct

Visualization










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