Gene Information gene info

GENE:ATP2A3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATP2A3
FullNmae ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:813
EnsembleID ENSG00000074370
Uniprot Q93084

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATP2A3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATP2A3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATP2A3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATP2A3 GO:0005388,GO:0005388,GO:0005388,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0006816,GO:0006874,GO:0006874,GO:0006919,GO:0008656,GO:0015085,GO:0016529,GO:0016887,GO:0030899,GO:0031090,GO:0031095,GO:0031965,GO:0033017,GO:0034220,GO:0044325,GO:0046872,GO:0070059,GO:0070588,GO:0070588,GO:0150104,GO:1900121,GO:1903515,GO:1903779

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATP2A3 hsa:489 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04148 Efferocytosis - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
ATP2A3 hsa:489 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 ATP2A3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 ATP2A3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ATP2A3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ATP2A3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ATP2A3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 ATP2A3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ATP2A3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C ATP2A3 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ATP2A3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ATP2A3 22851172 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ATP2A3 22851172 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ATP2A3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000007340 ATP2A3 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D ATP2A3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB ATP2A3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C ATP2A3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA ATP2A3 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GNAI3 ATP2A3 25348397 N/A physical interaction ComPPI
BCL2L11 ATP2A3 25348397 N/A physical interaction ComPPI
BMI1 ATP2A3 25348397 N/A physical interaction ComPPI
ERBB2 ATP2A3 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NCK1 ATP2A3 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
KCNA5 ATP2A3 25348397 N/A physical interaction ComPPI
CFTR ATP2A3 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BRF2 ATP2A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDK2 ATP2A3 25348397 N/A physical interaction ComPPI
IRS1 ATP2A3 12524443 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SLC4A8 ATP2A3 25348397 N/A physical interaction ComPPI
BCL2 ATP2A3 25348397 N/A physical interaction ComPPI
ESRRB ATP2A3 25348397 N/A physical interaction ComPPI
IL17RB ATP2A3 25348397 N/A physical interaction ComPPI
TCF3 ATP2A3 25348397 N/A physical interaction ComPPI
ATF2 ATP2A3 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CYLD ATP2A3 25348397 N/A physical interaction ComPPI
ATP2A3 WRAP73 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A3 SRPRB 25348397 N/A physical interaction ComPPI
ATP2A3 IL17RC 25348397 N/A physical interaction ComPPI
ATP2A3 IL1R1 25348397 N/A physical interaction ComPPI
ATP2A3 HLA-A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HNRNPA2B1 ATP2A3 24234451 30021884 physical association cross-linking study IntAct

Visualization