GENE：ATP2A3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATP2A3 |
| FullNmae | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:813 |
| EnsembleID | ENSG00000074370 |
| Uniprot | Q93084 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATP2A3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATP2A3 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATP2A3 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATP2A3 | GO:0005388,GO:0005388,GO:0005388,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0006816,GO:0006874,GO:0006874,GO:0006919,GO:0008656,GO:0015085,GO:0016529,GO:0016887,GO:0030899,GO:0031090,GO:0031095,GO:0031965,GO:0033017,GO:0034220,GO:0044325,GO:0046872,GO:0070059,GO:0070588,GO:0070588,GO:0150104,GO:1900121,GO:1903515,GO:1903779 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ATP2A3 | hsa:489 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa05412 | Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
| ATP2A3 | hsa:489 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | ATP2A3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | ATP2A3 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ATP2A3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ATP2A3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | ATP2A3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | ATP2A3 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ATP2A3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | ATP2A3 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ATP2A3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | ATP2A3 | 22851172 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | ATP2A3 | 22851172 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | ATP2A3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000007340 | ATP2A3 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | ATP2A3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000060AABB | ATP2A3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F1B8C | ATP2A3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002578DA | ATP2A3 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAI3 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| BCL2L11 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| BMI1 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| ERBB2 | ATP2A3 | 24189400 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| NCK1 | ATP2A3 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| KCNA5 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| CFTR | ATP2A3 | 17110338 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BRF2 | ATP2A3 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CDK2 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| IRS1 | ATP2A3 | 12524443 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| SLC4A8 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| BCL2 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| ESRRB | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| IL17RB | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| TCF3 | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| ATF2 | ATP2A3 | 22304920 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CYLD | ATP2A3 | 25348397 | N/A | physical interaction | ComPPI |
| ATP2A3 | WRAP73 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ATP2A3 | SRPRB | 25348397 | N/A | physical interaction | ComPPI |
| ATP2A3 | IL17RC | 25348397 | N/A | physical interaction | ComPPI |
| ATP2A3 | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
| ATP2A3 | HLA-A | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| HNRNPA2B1 | ATP2A3 | 24234451 30021884 | physical association | cross-linking study | IntAct |