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GENE：BBC3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BBC3
FullNmae BCL2 binding component 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17868
EnsembleID ENSG00000105327
Uniprot Q96PG8|Q9BXH1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BBC3 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BBC3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BBC3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BBC3 GO:0001836,GO:0005515,GO:0005739,GO:0005739,GO:0005764,GO:0006915,GO:0006919,GO:0051117,GO:0070059,GO:0090200,GO:0097194,GO:1900740,GO:2001244

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BBC3 hsa:27113 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
BBC3 hsa:27113 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
BBC3 hsa:27113 path:hsa04210 Apoptosis - Homo sapiens (human)
BBC3 hsa:27113 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
BBC3 hsa:27113 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
BBC3 hsa:27113 path:hsa05016 Huntington disease - Homo sapiens (human)
BBC3 hsa:27113 path:hsa05162 Measles - Homo sapiens (human)
BBC3 hsa:27113 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BBC3 hsa:27113 path:hsa05210 Colorectal cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL2 BBC3 11463391 11463392 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 association N/A ACSN
BBC3 BCL2A1 11463391 11463392 23430059 26192618 association N/A ACSN
MCL1 BBC3 11463391 11463392 23430059 23850759 26192618 association N/A ACSN
E2F1 BBC3 11463391 11463392 14634023 14684737 15279786 17218262 17303408 17660363 18590585 26192618 7575488 interaction type N/A ACSN
TP53 BBC3 16990795 18443131 19901969 23180781 physical association anti tag coimmunoprecipitation InnateDB
BBC3 NFKB2 16990795 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR1 BBC3 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
BBC3 BBC3 11463392 15694340 26467481 bind,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
ETS1 BBC3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 BBC3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 BBC3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 BBC3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 BBC3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 BBC3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC BBC3 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC BBC3 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 BBC3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 BBC3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 BBC3 11572983 11756653 15988033 17280505 18755897 18971253 22763818 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP53 BBC3 11572983 11756653 15988033 17280505 18755897 18971253 22763818 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR1I2 BBC3 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 BBC3 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BBC3 18971253 20818159 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BBC3 18971253 20818159 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BBC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BBC3 17263886 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BBC3 17263886 trascriptional regulation,stimulation inferred by curator TFlink
ETV6 BBC3 16828711 trascriptional regulation,stimulation inferred by curator TFlink
ETV6 BBC3 16828711 trascriptional regulation,stimulation inferred by curator TFlink
FOXO3 BBC3 21654193 trascriptional regulation,stimulation inferred by curator TFlink
FOXO3 BBC3 21654193 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L1 BBC3 23684607 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L1 BBC3 23684607 trascriptional regulation,stimulation inferred by curator TFlink
TCF3 BBC3 23684607 trascriptional regulation,stimulation inferred by curator TFlink
TCF3 BBC3 23684607 trascriptional regulation,stimulation inferred by curator TFlink
TP73 BBC3 17700533 trascriptional regulation,stimulation inferred by curator TFlink
TP73 BBC3 17700533 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 BBC3 20018759 20813046 rna interference,inhibition array technology,experimental interaction detection,western blot,northern blot,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000153377 BBC3 20813046 rna interference,inhibition experimental interaction detection,western blot,northern blot,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00001C3AC1 BBC3 21633093 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000003575B BBC3 20388800 rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 BBC3 20018759 20813046 21042732 22075712 22743998 25416803 26249174 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS0000153377 BBC3 20813046 21042732 22075712 22743998 24452416 25416803 26249174 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000003575B BBC3 20388800 25416803 27120784 mrna cleavage,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001C3AC1 BBC3 21633093 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005CC20C BBC3 20542001 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00001C770D BBC3 23873935 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000001A7A BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 BBC3 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A3D BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 BBC3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 BBC3 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000451A1 BBC3 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000006DA05 BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000018E72A BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B0B46 BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076E54 BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000035D2F9 BBC3 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000122F23 BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000018CD09 BBC3 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000030F801 BBC3 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 BBC3 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 BBC3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 BBC3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000353492 BBC3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 BBC3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005651EE BBC3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ERBB2 BBC3 22135298 phosphorylation N/A PhosphoSite
CHUK BBC3 22135298 phosphorylation N/A PhosphoSite
IKBKB BBC3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBASH3B BBC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 BBC3 15694340 16697956 24234451 25348397 N/A fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,IntAct
BCL2L2 BBC3 14525934 15694340 16697956 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCL2L1 BBC3 16697956 24234451 25348397 N/A two hybrid,fluorescence polarization spectroscopy,physical interaction,in vitro,surface plasmon resonance array ComPPI,IntAct
BCL2L1 BBC3 14525934 15574335 15694340 16697956 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
HGS BBC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MCL1 BBC3 16697956 22516262 24234451 25348397 26431330 association anti bait coimmunoprecipitation,fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,IntAct
MCL1 BBC3 14525934 16697956 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EGFR BBC3 25348397 N/A physical interaction ComPPI
EGFR BBC3 25348397 N/A physical interaction ComPPI
BCL2A1 BBC3 16697956 24234451 25348397 N/A fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,IntAct
BCL2A1 BBC3 14525934 15694340 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCL2 BBC3 15694340 16697956 17289999 24234451 25348397 26431330 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,IntAct
BCL2 BBC3 11463392 14525934 16697956 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BAX BBC3 25348397 N/A two hybrid ComPPI
FHL5 BBC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CKMT1A BBC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WDR5 BBC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BBC3 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ALB BBC3 25348397 N/A physical interaction ComPPI
MYPOP BBC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BBC3 NDUFAB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BBC3 ZNF438 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BAX BBC3 14525934 15574335 N/A two hybrid HPRD
BBC3 BCL2L1 15694340 27898060 inhibition N/A OmniPath
BBC3 BCL2L1 15574335 15694340 15721256 16697956 19074266 27898060 inhibition N/A OmniPath
BBC3 BCL2 15694340 27898060 inhibition N/A OmniPath
BBC3 BCL2 11463392 15694340 16697956 17289999 27898060 inhibition N/A OmniPath
BBC3 BAK1 17289999 22492984 27898060 stimulant N/A OmniPath
TRIM28 BBC3 17942393 27898060 inhibition N/A OmniPath
TP53 BBC3 11463392 12574499 27898060 inhibition,stimulant N/A OmniPath
TP53 BBC3 16151013 27898060 inhibition,stimulant N/A OmniPath
BBC3 MCL1 15694340 27898060 inhibition N/A OmniPath
BBC3 MCL1 15694340 15721256 16697956 21613222 21730980 26186194 27898060 inhibition N/A OmniPath
BBC3 BCL2A1 15694340 27898060 inhibition N/A OmniPath
BBC3 BCL2L2 15694340 27898060 inhibition N/A OmniPath
SP1 BBC3 18811981 27898060 stimulant N/A OmniPath
BBC3 BAX 15574335 27898060 stimulant N/A OmniPath
TP73 BBC3 19788416 27898060 stimulant N/A OmniPath
ERBB2 BBC3 24236056 27898060 N/A N/A OmniPath
BBC3 BCL2L2 15694340 16697956 27898060 inhibition N/A OmniPath
BBC3 BAX 1557433 15574335 19439449 27898060 stimulant N/A OmniPath
IKBKB BBC3 21364664 21997190 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AFE3B BBC3 27087310 direct interaction,inhibition N/A NPInter

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