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GENE：MAP3K11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K11
FullNmae mitogen-activated protein kinase kinase kinase 11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6850
EnsembleID ENSG00000173327
Uniprot Q16584

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K11 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K11 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K11 GO:0000165,GO:0004672,GO:0004674,GO:0004706,GO:0004706,GO:0004706,GO:0004709,GO:0005515,GO:0005524,GO:0005813,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0007017,GO:0007017,GO:0007254,GO:0016020,GO:0031267,GO:0031434,GO:0031435,GO:0042802,GO:0042803,GO:0043065,GO:0043507,GO:0043525,GO:0044843,GO:0046330,GO:0046777,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K11 hsa:4296 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP3K11 hsa:4296 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IKBKB MAP3K11 10713178 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
APP MAP3K11 12917434 23180781 physical association gst pull down InnateDB
MAP3K11 CHUK 10713178 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
AKT1 MAP3K11 12458207 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K11 TRAF2 19918265 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K11 TRAF5 19918265 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 MAP3K11 19918265 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP4K1 MAP3K11 11053428 18988627 23331499 9003777 stimulation N/A SignaLink,SignaLink
MAPK8IP3 MAP3K11 10629060 18988627 23331499 stimulation N/A SignaLink,SignaLink
MAP3K11 MAP2K4 23331499 8702571 stimulation N/A SignaLink
MAP3K11 MAP2K3 23331499 9003778 stimulation N/A SignaLink
MAP3K11 MAP2K6 23331499 9003778 stimulation N/A SignaLink
CDC42 MAP3K11 23331499 9829970 stimulation N/A SignaLink
RAC1 MAP3K11 11713255 23331499 9427749 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DLG4 MAP3K11 20005715 interaction type N/A PSP
KIFAP3 MAP3K11 20005715 interaction type N/A PSP
MAPK8IP1 MAP3K11 20005715 interaction type N/A PSP
MAPK8IP2 MAP3K11 10490659 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
MAPK8IP3 MAP3K11 20005715 interaction type N/A PSP
KIFAP3 MAP3K11 20005715 21071413 9427749 N/A N/A SignaLink
MAPK8IP1 MAP3K11 10490659 10490659 10490659 16456539 18988627 20005715 20005715 21071413 N/A N/A SignaLink
MAPK8IP3 MAP3K11 20005715 20005715 N/A N/A SignaLink
DLG4 MAP3K11 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAP3K11 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MAP3K11 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP3K11 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 MAP3K11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MAP3K11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP3K11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP3K11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP3K11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MAP3K11 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 MAP3K11 22942087 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
MAP4K1 MAP3K11 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
GSK3A MAP3K11 22135298 phosphorylation N/A PhosphoSite
MAP3K11 MAP3K11 22135298 phosphorylation N/A PhosphoSite
MAP3K11 MAP2K3 22135298 phosphorylation N/A PhosphoSite
MAP3K11 PIN1 22135298 phosphorylation N/A PhosphoSite
MAP3K11 PRKAA1 22135298 phosphorylation N/A PhosphoSite
MAP3K11 MAP2K4 22135298 phosphorylation N/A PhosphoSite
AKT1 MAP3K11 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CDC37 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 CDC37 25361965 interaction type N/A PTMCode2
DLG4 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 DLG4 25361965 interaction type N/A PTMCode2
MAP3K11 AKT1 25361965 interaction type N/A PTMCode2
MAP4K2 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 MAP4K2 25361965 interaction type N/A PTMCode2
MAPK8IP1 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 MAPK8IP1 25361965 interaction type N/A PTMCode2
SH3RF1 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 SH3RF1 25361965 interaction type N/A PTMCode2
MAP3K11 CDC42 25361965 interaction type N/A PTMCode2
CDC42 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 RAC1 25361965 interaction type N/A PTMCode2
RAC1 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 MAP4K1 25361965 interaction type N/A PTMCode2
MAP3K11 MAP2K7 25361965 interaction type N/A PTMCode2
MAP2K7 MAP3K11 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 MAP3K11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC42 MAP3K11 10799501 14525934 16253996 20890305 24234451 25241761 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
TRAF6 MAP3K11 25348397 N/A physical interaction ComPPI
RAC1 MAP3K11 14525934 25348397 9427749 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HSP90AB1 MAP3K11 25348397 N/A physical interaction ComPPI
DLG4 MAP3K11 25348397 N/A physical interaction ComPPI
NF2 MAP3K11 20890305 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct
CBL MAP3K11 25348397 N/A physical interaction ComPPI
RHOG MAP3K11 12376551 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK8 MAP3K11 24234451 25284480 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3R1 MAP3K11 24234451 25284480 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
MAP4K2 MAP3K11 11784851 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MAP4K1 MAP3K11 11053428 14525934 24234451 25348397 9346925 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
COPS5 MAP3K11 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GSK3B MAP3K11 25348397 N/A physical interaction ComPPI
HSP90AA1 MAP3K11 25348397 N/A physical interaction ComPPI
EPS8 MAP3K11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KIFAP3 MAP3K11 25348397 N/A physical interaction ComPPI
MAP2K4 MAP3K11 25348397 N/A physical interaction ComPPI
IKBKB MAP3K11 10713178 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK8IP3 MAP3K11 10629060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GSK3A MAP3K11 20368287 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MAPK8IP1 MAP3K11 10490659 14525934 16456539 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PKM MAP3K11 25348397 N/A protein kinase assay ComPPI
MAPK8IP2 MAP3K11 10490659 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP3K11 MAP3K12 25348397 N/A in vitro,in vivo ComPPI
MAP3K11 CHUK 10713178 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K11 MAP2K7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAP3K11 SH3RF1 14504284 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K11 AKT1 12458207 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K11 KIF17 25348397 N/A physical interaction ComPPI
MAP3K11 KIF3A 14525934 25348397 9427749 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
MAP3K11 KIF3B 25348397 N/A physical interaction ComPPI
MAP3K11 TRAF2 25348397 N/A physical interaction ComPPI
MAP3K11 CLEC4G 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K11 TRIM5 25348397 N/A physical interaction ComPPI
MAP3K11 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP3K11 CDC37 25348397 N/A physical interaction ComPPI
MAP3K11 APP 25348397 N/A physical interaction ComPPI
MAP3K11 HSPA4 25348397 N/A physical interaction ComPPI
MAP3K11 STUB1 25348397 N/A physical interaction ComPPI
MAP3K11 MAP3K21 25348397 N/A physical interaction ComPPI
MAP3K11 MAP3K11 11053428 11590155 12376551 14525934 N/A experimental interaction detection HPRD
CHUK MAP3K11 10713178 27898060 N/A N/A OmniPath
TRAF2 MAP3K11 19918265 27898060 N/A N/A OmniPath
MAP3K11 PIN1 21988832 22566623 25519816 27898060 stimulant N/A OmniPath
APP MAP3K11 12917434 27898060 N/A N/A OmniPath
MAP3K11 TRAF6 19586614 19918265 23172226 27898060 N/A N/A OmniPath
TRAF6 MAP3K11 19586614 19918265 23172226 27898060 N/A N/A OmniPath
AKT1 MAP3K11 12458207 26152725 27898060 inhibition,stimulant N/A OmniPath
MAP3K11 AKT1 12458207 27898060 N/A N/A OmniPath
SH3RF1 MAP3K11 12514131 14504284 27898060 stimulant N/A OmniPath
MAP3K11 MAP2K4 10727406 11053428 15328343 16000309 17276500 27898060 8702571 9003778 9162092 stimulant N/A OmniPath
GSK3A MAP3K11 11969422 17711861 20368287 27898060 N/A N/A OmniPath
MAP3K11 MAP2K3 27898060 9003778 stimulant N/A OmniPath
RAC1 MAP3K11 11713255 27898060 9427749 stimulant N/A OmniPath
MAPK14 MAP3K11 20626350 27898060 inhibition N/A OmniPath
MAP3K11 MAP2K6 27898060 9003778 stimulant N/A OmniPath
CDC42 MAP3K11 10799501 16253996 20890305 25241761 27898060 9427749 9829970 stimulant N/A OmniPath
IKBKB MAP3K11 10713178 27898060 N/A N/A OmniPath
TRAF5 MAP3K11 19918265 27898060 N/A N/A OmniPath
MAPK8IP3 MAP3K11 10629060 27898060 stimulant N/A OmniPath
MAP4K1 MAP3K11 11053428 11969422 12458207 27898060 9003777 9346925 stimulant N/A OmniPath

Visualization










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