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GENE：BCLAF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCLAF1
FullNmae BCL2 associated transcription factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16863
EnsembleID ENSG00000029363
Uniprot Q9NYF8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCLAF1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCLAF1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCLAF1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCLAF1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BCLAF1 GO:0003677,GO:0003677,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006915,GO:0006974,GO:0016592,GO:0016607,GO:0043065,GO:0043620,GO:0045892,GO:0045892,GO:0045944,GO:1990830,GO:2000144,GO:2001244

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 BCLAF1 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 BCLAF1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 BCLAF1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
BMI1 BCLAF1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR BCLAF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 BCLAF1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 BCLAF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 BCLAF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 BCLAF1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 BCLAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BCLAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BCLAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BCLAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCLAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BCLAF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB BCLAF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 BCLAF1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000070B1D BCLAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 BCLAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000148B91 BCLAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000096022 BCLAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 BCLAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003ABC4 BCLAF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003BD367 BCLAF1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA BCLAF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B BCLAF1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C BCLAF1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D BCLAF1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 BCLAF1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 BCLAF1 25416803 27449900 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SRC BCLAF1 22135298 phosphorylation N/A PhosphoSite
GSK3B BCLAF1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 BCLAF1 25348397 N/A physical interaction ComPPI
SNW1 BCLAF1 18794151 20467437 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving ComPPI,IntAct
CDC5L BCLAF1 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CBX8 BCLAF1 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
BAG3 BCLAF1 25348397 N/A physical interaction ComPPI
EMD BCLAF1 14525934 15009215 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,far western blotting,scintillation proximity assay,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
VCP BCLAF1 25348397 N/A physical interaction ComPPI
YWHAG BCLAF1 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
BMI1 BCLAF1 25348397 N/A physical interaction ComPPI
KEAP1 BCLAF1 25348397 N/A physical interaction ComPPI
SNIP1 BCLAF1 18794151 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction ComPPI,IntAct
BCL2L1 BCLAF1 10330179 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SNRNP70 BCLAF1 25348397 N/A physical interaction ComPPI
PRKCD BCLAF1 17938203 24234451 25348397 association chromatin immunoprecipitation assay ComPPI,IntAct
GRB2 BCLAF1 12577067 24234451 25348397 association pull down ComPPI,IntAct
SFPQ BCLAF1 20932480 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
U2AF2 BCLAF1 25348397 N/A physical interaction ComPPI
PAXIP1 BCLAF1 25348397 N/A physical interaction ComPPI
CUL3 BCLAF1 25348397 N/A physical interaction ComPPI
PDGFRB BCLAF1 25348397 N/A physical interaction ComPPI
DLD BCLAF1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 BCLAF1 25348397 N/A physical interaction ComPPI
PRMT1 BCLAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LEMD3 BCLAF1 14525934 15681850 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CLK2 BCLAF1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CLK1 BCLAF1 25348397 N/A physical interaction ComPPI
CSNK2A1 BCLAF1 25348397 N/A physical interaction,protein kinase assay ComPPI
UHRF2 BCLAF1 25348397 N/A physical interaction ComPPI
THOC5 BCLAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRK5 BCLAF1 25348397 N/A physical interaction ComPPI
XPO1 BCLAF1 25348397 N/A physical interaction ComPPI
THOC1 BCLAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARRB1 BCLAF1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRPK1 BCLAF1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ARRB2 BCLAF1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK2A2 BCLAF1 25348397 N/A physical interaction ComPPI
CDK2 BCLAF1 25348397 N/A physical interaction ComPPI
EGFR BCLAF1 25348397 N/A physical interaction ComPPI
RNF2 BCLAF1 25348397 N/A physical interaction ComPPI
PPHLN1 BCLAF1 25348397 N/A physical interaction ComPPI
CCNB1 BCLAF1 25348397 N/A physical interaction ComPPI
CASP10 BCLAF1 23541952 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MTA3 BCLAF1 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
BCL2 BCLAF1 10330179 14525934 23541952 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
CORO2A BCLAF1 25348397 N/A physical interaction ComPPI
CUL7 BCLAF1 25348397 N/A physical interaction ComPPI
H3C1 BCLAF1 25348397 N/A physical interaction ComPPI
HDAC11 BCLAF1 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAND1 BCLAF1 25348397 N/A physical interaction ComPPI
BCLAF1 CHD1 25348397 N/A physical interaction ComPPI
BCLAF1 ESR1 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
BCLAF1 BARD1 25348397 N/A physical interaction ComPPI
BCLAF1 SMURF1 25348397 N/A physical interaction ComPPI
BCLAF1 PAN2 25348397 N/A physical interaction ComPPI
BCLAF1 CLK3 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
BCLAF1 SRPK2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
BCLAF1 TARDBP 25348397 N/A physical interaction ComPPI
BCLAF1 ASB3 25348397 N/A physical interaction ComPPI
BCLAF1 ZBTB1 25348397 N/A physical interaction ComPPI
BCLAF1 SART3 25348397 N/A physical interaction ComPPI
BCLAF1 MOV10 25348397 N/A physical interaction ComPPI
BCLAF1 NXF1 25348397 N/A physical interaction ComPPI
BCLAF1 OBSL1 25348397 N/A physical interaction ComPPI
BCLAF1 SUZ12 25348397 N/A physical interaction ComPPI
BCLAF1 LUZP4 25348397 N/A physical interaction ComPPI
BCLAF1 SPIN1 25348397 N/A physical interaction ComPPI
BCLAF1 PRMT8 25348397 N/A physical interaction ComPPI
BCLAF1 LUC7L 25348397 N/A physical interaction ComPPI
BCLAF1 LUC7L2 25348397 N/A physical interaction ComPPI
BCLAF1 UNK 25348397 N/A physical interaction ComPPI
BCLAF1 RPS9 25348397 N/A physical interaction ComPPI
BCLAF1 THRAP3 18794151 24234451 25348397 26496610 colocalization,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
BCLAF1 MED4 25348397 N/A physical interaction ComPPI
BCLAF1 AHSA1 25348397 N/A physical interaction ComPPI
BCLAF1 FMR1 25348397 N/A physical interaction ComPPI
BCLAF1 DDX39B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 FXR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 PABPN1 25348397 N/A physical interaction ComPPI
BCLAF1 SRSF9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 APOBEC3B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 MYH7B 25348397 N/A physical interaction ComPPI
BCLAF1 CDKN2AIPNL 25348397 N/A physical interaction ComPPI
BCLAF1 ZC3H11A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 ALYREF 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 SPEN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 VIRMA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 CHTOP 25348397 N/A physical interaction ComPPI
BCLAF1 CDK12 25348397 N/A physical interaction ComPPI
BCLAF1 THOC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 THOC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 THOC7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 POLDIP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 THOC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 RBMXL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCLAF1 GAN 25348397 N/A physical interaction ComPPI
BCLAF1 ALKBH3 25348397 N/A physical interaction ComPPI
BCLAF1 NANOGP8 25348397 N/A physical interaction ComPPI
BCLAF1 NANOG 25348397 N/A physical interaction ComPPI
BCLAF1 ZMIZ1 25348397 N/A physical interaction ComPPI
BCLAF1 PNN 18794151 24234451 25348397 colocalization molecular sieving,physical interaction ComPPI,IntAct
BCLAF1 CYLD 25348397 N/A physical interaction ComPPI
BCLAF1 PARK7 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
BCLAF1 RNPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BCLAF1 ESR2 21182203 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
BCLAF1 MAGOH 23084401 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BCLAF1 MCM7 23764002 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
BCLAF1 ZC3H18 24234451 25348397 29298432 association anti tag coimmunoprecipitation ComPPI,IntAct
BCLAF1 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
SRRM1 BCLAF1 25348397 N/A physical interaction ComPPI
EIF4A3 BCLAF1 23084401 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BCLAF1 RP1 24234451 30021884 physical association cross-linking study IntAct
L1TD1 BCLAF1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
SRC BCLAF1 17570479 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B92CD BCLAF1 27087310 direct interaction,inhibition N/A NPInter
URS00009B294B BCLAF1 27087310 direct interaction,inhibition N/A NPInter

Visualization










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