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GENE：BDKRB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BDKRB2
FullNmae bradykinin receptor B2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1030
EnsembleID ENSG00000168398
Uniprot P30411

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BDKRB2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BDKRB2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BDKRB2 GO:0002020,GO:0004435,GO:0004947,GO:0004947,GO:0005515,GO:0005768,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0006939,GO:0006954,GO:0007166,GO:0007169,GO:0007186,GO:0007204,GO:0008015,GO:0009651,GO:0019229,GO:0031702,GO:0033137,GO:0042310,GO:0042311,GO:0043114,GO:0043231,GO:0046982,GO:0050482,GO:1902239,GO:1990127

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BDKRB2 hsa:624 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa05142 Chagas disease - Homo sapiens (human)
BDKRB2 hsa:624 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR BDKRB2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
HIF1A BDKRB2 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 BDKRB2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA BDKRB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BDKRB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BDKRB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BDKRB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BDKRB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BDKRB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 BDKRB2 15632413 trascriptional regulation,stimulation inferred by curator TFlink
KLF4 BDKRB2 15632413 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BDKRB2 15632413 trascriptional regulation,stimulation inferred by curator TFlink
SP1 BDKRB2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003003B4 BDKRB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 BDKRB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005F305A BDKRB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB BDKRB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C BDKRB2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC BDKRB2 22135298 phosphorylation N/A PhosphoSite
GRK4 BDKRB2 22135298 phosphorylation N/A PhosphoSite
PRKCA BDKRB2 22135298 phosphorylation N/A PhosphoSite
ACE BDKRB2 25361965 interaction type N/A PTMCode2
BDKRB2 ACE 25361965 interaction type N/A PTMCode2
GNA11 BDKRB2 25361965 interaction type N/A PTMCode2
BDKRB2 GNA11 25361965 interaction type N/A PTMCode2
AGTR1 BDKRB2 25361965 interaction type N/A PTMCode2
BDKRB2 AGTR1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NOS3 BDKRB2 10510297 10681501 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BAG3 BDKRB2 25348397 N/A physical interaction ComPPI
AGTR1 BDKRB2 10993080 24234451 25348397 27898060 28298427 physical association ubiquitin reconstruction,physical interaction,in vivo ComPPI,IntAct,OmniPath
PTPN11 BDKRB2 12177051 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PRKCD BDKRB2 11517230 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRK6 BDKRB2 11517230 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRK5 BDKRB2 11517230 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRK2 BDKRB2 11517230 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BDKRB2 GRK4 25348397 N/A in vitro,in vivo ComPPI
BDKRB2 GNA11 12130679 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BDKRB2 NOS1 10681501 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BDKRB2 ACE 10748135 14525934 17077303 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
GRK3 BDKRB2 11517230 14525934 N/A experimental interaction detection HPRD
BDKRB2 CD82 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 EFS 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 INF2 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 AATK 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 PEX16 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 TMEM70 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 TMEM11 24234451 28298427 physical association ubiquitin reconstruction IntAct
MPI BDKRB2 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 CLCA4 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 CD81 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 HERC2 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 TPI1 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 SYNE1 24234451 28298427 physical association ubiquitin reconstruction IntAct
SPNS1 BDKRB2 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 SPG7 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 SLC35A4 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 SLC2A8 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 SYNGR2 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 AP2M1 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 NIF3L1 24234451 28298427 physical association ubiquitin reconstruction IntAct
BDKRB2 USP4 24234451 28298427 physical association ubiquitin reconstruction IntAct
SRC BDKRB2 16226010 27898060 stimulant N/A OmniPath
PRKCA BDKRB2 11517230 27898060 N/A N/A OmniPath
PRKCD BDKRB2 11517230 27898060 inhibition N/A OmniPath
TP53 BDKRB2 18431400 27898060 stimulant N/A OmniPath
GRK2 BDKRB2 11517230 27898060 inhibition N/A OmniPath
GRK5 BDKRB2 11517230 27898060 inhibition N/A OmniPath
KNG1 BDKRB2 27898060 8063797 8302267 N/A N/A OmniPath
GRK6 BDKRB2 11517230 27898060 inhibition N/A OmniPath
GRK4 BDKRB2 11517230 15161928 27898060 inhibition N/A OmniPath
GRK3 BDKRB2 11517230 27898060 inhibition N/A OmniPath

Visualization










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