Gene Information gene info

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GENE：BIK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BIK
FullNmae BCL2 interacting killer
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1051
EnsembleID ENSG00000100290
Uniprot Q13323

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BIK apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BIK apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BIK GO:0005515,GO:0006915,GO:0008584,GO:0008637,GO:0012505,GO:0031334,GO:0031966,GO:0042981,GO:0090200,GO:0097136

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BIK hsa:638 path:hsa01522 Endocrine resistance - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BIK BCL2 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIK BCL2L1 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP BIK 21832049 23180781 physical association protein array InnateDB
BCL2A1 BIK 23180781 25416956 physical association two hybrid InnateDB
BCL2L2 BIK 23180781 25416956 physical association two hybrid InnateDB
BIK FATE1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 BIK 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 BIK 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 BIK 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 BIK 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C BIK 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 BIK 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BIK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BIK N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 BIK N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 BIK 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000521626 BIK 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000209905 BIK 25416803 27702798 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 BIK 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 BIK 22135298 phosphorylation N/A PhosphoSite
BIK BCL2L2 25361965 interaction type N/A PTMCode2
BCL2L2 BIK 25361965 interaction type N/A PTMCode2
BIK BCL2A1 25361965 interaction type N/A PTMCode2
BCL2A1 BIK 25361965 interaction type N/A PTMCode2
BIK BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BIK 25361965 interaction type N/A PTMCode2
BIK BCL2 25361965 interaction type N/A PTMCode2
BCL2 BIK 25361965 interaction type N/A PTMCode2
BIK MCL1 25361965 interaction type N/A PTMCode2
MCL1 BIK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SOCS3 BIK 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TMEM11 BIK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L11 BIK 23235460 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
ADIPOQ BIK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM199 BIK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22A BIK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP5 BIK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 BIK 14525934 15694340 16697956 24234451 25348397 25416956 27107012 physical association two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,two hybrid array,in vitro,surface plasmon resonance array,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
BIK FATE1 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIK BCL2A1 10381646 14525934 24234451 25348397 25416956 physical association experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
BIK MCL1 14525934 16697956 24234451 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,HPRD,IntAct
BIK BCL2 12853473 14525934 16697956 17289999 24234451 25348397 9463381 9525867 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
BIK APP 25348397 N/A physical interaction ComPPI
BIK CRKL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BIK NR2F2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BIK TANK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BIK CREB3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BIK UBC 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
BIK UBA52 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
BIK BCL2L10 23235460 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
BIK ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK REEP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK FCGR1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SLC35E3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK KCNN4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM14B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM80 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TTMP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK MARCHF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMBIM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CYB561 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SCAMP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK PGRMC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CNIH3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK INSIG2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SELENOK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM243 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CYB5B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK UBIAD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK APOD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK PLN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK ALG8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK NAT8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM14C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK RUSF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CMTM7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK BTN2A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM222 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SLC37A4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SLC39A7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM86B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SERP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CD72 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM60 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK ZFPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK ADGRE2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK PLP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SERP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK GRM2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK PLPP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CD53 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK NRM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK FAM3C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM97 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM107 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TSPO2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CTXN3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK STRIT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK BMP10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK EXOC3L2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM229B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK NRAC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK CNIH1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK TMEM254 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK MS4A13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIK SMIM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 BIK 11342619 12853473 14525934 16189514 16697956 24234451 25348397 26871637 27107012 9525867 physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,surface plasmon resonance array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
UBB BIK 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RPS27A BIK 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
STX8 BIK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP3 BIK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 BIK 11342619 12853473 15694340 15721256 16189514 16697956 22705850 27898060 9305912 9525867 inhibition N/A OmniPath
BIK BCL2L1 11342619 12853473 15694340 15721256 16189514 16697956 22705850 27898060 7478623 9525867 inhibition N/A OmniPath
BCL2 BIK 12853473 15694340 16697956 17289999 22705850 27898060 8816500 9305912 9463381 9488477 9525867 inhibition N/A OmniPath
BCL2L2 BIK 10381646 15694340 16697956 25416956 27898060 inhibition N/A OmniPath
CSNK2A1 BIK 11084041 14633680 24637719 27898060 stimulant N/A OmniPath

Visualization










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