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GENE：BIRC6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BIRC6
FullNmae baculoviral IAP repeat containing 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13516
EnsembleID ENSG00000115760
Uniprot Q9NR09

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BIRC6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BIRC6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BIRC6 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BIRC6 GO:0000922,GO:0004842,GO:0004869,GO:0004869,GO:0005515,GO:0005634,GO:0005768,GO:0005802,GO:0005815,GO:0005829,GO:0006468,GO:0006915,GO:0007049,GO:0008283,GO:0008284,GO:0016020,GO:0016567,GO:0030496,GO:0032465,GO:0042127,GO:0043066,GO:0043066,GO:0043066,GO:0051301,GO:0060711,GO:0061631,GO:0090543,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BIRC6 hsa:57448 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
BIRC6 hsa:57448 path:hsa04140 Autophagy - animal - Homo sapiens (human)
BIRC6 hsa:57448 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BIRC6 DIABLO 14765125 15200957 15300255 15507451 15781261 23180781 26192618 interaction type,ubiquitination reaction,physical association anti tag coimmunoprecipitation,ubiquitination reaction ACSN,InnateDB
HTRA2 BIRC6 10521396 11583623 11803371 12815069 12835328 15781261 19935698 20125124 23070005 26192618 interaction type N/A ACSN
RNF41 BIRC6 14765125 26192618 interaction type N/A ACSN
BIRC6 CASP9 15300255 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,ubiquitination reaction InnateDB
BIRC6 HTRA2 15300255 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIRC6 XIAP 15507451 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR BIRC6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BIRC6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BIRC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BIRC6 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 BIRC6 17942906 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00003D5391 BIRC6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 BIRC6 23622248 25416803 28097098 mrna cleavage,inhibition array technology,clash TarBase
URS0000148B91 BIRC6 25416803 26919240 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
USP8 BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 USP8 25361965 interaction type N/A PTMCode2
CASP9 BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 CASP9 25361965 interaction type N/A PTMCode2
CASP3 BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 CASP3 25361965 interaction type N/A PTMCode2
RNF41 BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 RNF41 25361965 interaction type N/A PTMCode2
HTRA2 BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 HTRA2 25361965 interaction type N/A PTMCode2
DIABLO BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 DIABLO 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MOS BIRC6 25348397 N/A physical interaction ComPPI
CCDC22 BIRC6 25348397 N/A physical interaction ComPPI
CASP9 BIRC6 14525934 15300255 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2D1 BIRC6 25348397 N/A physical interaction ComPPI
RACK1 BIRC6 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
VAV2 BIRC6 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ABRAXAS2 BIRC6 25348397 N/A physical interaction ComPPI
RAB8A BIRC6 14525934 18329369 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 BIRC6 14525934 15200957 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBC BIRC6 25348397 N/A physical interaction ComPPI
ANGPTL3 BIRC6 25348397 N/A physical interaction ComPPI
PLK1 BIRC6 14525934 18329369 24234451 25348397 26496610 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
CASP7 BIRC6 25348397 N/A physical interaction ComPPI
CASP8 BIRC6 25348397 N/A physical interaction ComPPI
MAP2K1 BIRC6 14525934 18329369 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
HEY1 BIRC6 25348397 N/A physical interaction ComPPI
CSNK2A1 BIRC6 22113938 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
VCL BIRC6 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
GOLGA4 BIRC6 18329369 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
EXOC3 BIRC6 14525934 18329369 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EXOC4 BIRC6 14525934 18329369 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
PSMC5 BIRC6 25348397 N/A physical interaction ComPPI
CLEC11A BIRC6 25348397 N/A physical interaction ComPPI
RASSF2 BIRC6 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
USP8 BIRC6 14525934 18329369 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VEGFD BIRC6 25348397 N/A physical interaction ComPPI
DIABLO BIRC6 14525934 15200957 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HTRA2 BIRC6 14525934 15200957 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ADAMTS4 BIRC6 25348397 N/A physical interaction ComPPI
RNF41 BIRC6 25348397 N/A physical interaction ComPPI
BIRC5 BIRC6 14525934 18329369 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPS15L1 BIRC6 25348397 N/A physical interaction ComPPI
CCNA2 BIRC6 25348397 N/A physical interaction ComPPI
SSH3 BIRC6 25348397 N/A physical interaction ComPPI
KIF23 BIRC6 18329369 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
KIF22 BIRC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC6 SIRT7 25348397 N/A physical interaction ComPPI
BIRC6 GBF1 25348397 N/A physical interaction ComPPI
BIRC6 CDC27 25348397 N/A physical interaction ComPPI
BIRC6 ANAPC11 25348397 N/A physical interaction ComPPI
BIRC6 TEX35 25348397 N/A physical interaction ComPPI
BIRC6 PRSS45P 25348397 N/A physical interaction ComPPI
BIRC6 RTBDN 25348397 N/A physical interaction ComPPI
BIRC6 C3ORF20 25348397 N/A physical interaction ComPPI
BIRC6 WDR4 25348397 N/A physical interaction ComPPI
BIRC6 GSDME 25348397 N/A physical interaction ComPPI
BIRC6 CA11 25348397 N/A physical interaction ComPPI
BIRC6 HERC2 25348397 N/A physical interaction ComPPI
BIRC6 HERC2P3 25348397 N/A physical interaction ComPPI
BIRC6 CHIA 25348397 N/A physical interaction ComPPI
BIRC6 TBC1D22A 25348397 N/A physical interaction ComPPI
BIRC6 CCNQ 25348397 N/A physical interaction ComPPI
BIRC6 MCPH1 25348397 N/A physical interaction ComPPI
BIRC6 TP53 25348397 N/A physical interaction ComPPI
BIRC6 UNK 25348397 N/A physical interaction ComPPI
BIRC6 RPGR 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
BIRC6 LLGL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC6 MYH13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC6 AGRP 25348397 N/A physical interaction ComPPI
BIRC6 UGGT2 25348397 N/A physical interaction ComPPI
BIRC6 AKAP9 25348397 N/A physical interaction ComPPI
BIRC6 DCAF12 25348397 N/A physical interaction ComPPI
BIRC6 FERMT2 25348397 N/A physical interaction ComPPI
BIRC6 OSBPL2 25348397 N/A physical interaction ComPPI
BIRC6 AURKB 18329369 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
BIRC6 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 BIRC6 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HSCB BIRC6 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
BIRC6 CDK1 14525934 18329369 N/A experimental interaction detection HPRD
RRBP1 BIRC6 24234451 30021884 physical association cross-linking study IntAct
GOLGB1 BIRC6 24234451 30021884 physical association cross-linking study IntAct
NUMA1 BIRC6 24234451 30021884 physical association cross-linking study IntAct
H2AC12 BIRC6 24234451 30021884 physical association cross-linking study IntAct
BIRC6 CASP7 15200957 15507451 27898060 inhibition N/A OmniPath
CASP3 BIRC6 15200957 15507451 27898060 inhibition N/A OmniPath
BIRC6 CASP3 15200957 15507451 27898060 inhibition N/A OmniPath
CASP9 BIRC6 15200957 15300255 15507451 27898060 inhibition N/A OmniPath
BIRC6 CASP9 15200957 15300255 15507451 27898060 inhibition N/A OmniPath
HTRA2 BIRC6 15200957 15300255 15507451 15781261 27898060 inhibition N/A OmniPath
BIRC6 HTRA2 15200957 15300255 15507451 15781261 27898060 inhibition N/A OmniPath
BIRC6 DIABLO 15200957 15300255 15507451 15781261 20957035 22788920 24302728 27898060 inhibition N/A OmniPath
DIABLO BIRC6 15200957 15300255 15507451 15781261 20957035 22788920 24302728 27898060 inhibition N/A OmniPath

Visualization










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