GENE：BRSK2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BRSK2 |
| FullNmae | BR serine/threonine kinase 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11405 |
| EnsembleID | ENSG00000174672 |
| Uniprot | Q8IWQ3 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BRSK2 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BRSK2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BRSK2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BRSK2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BRSK2 | GO:0000086,GO:0000287,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005783,GO:0005813,GO:0005813,GO:0006468,GO:0006468,GO:0006887,GO:0007409,GO:0007409,GO:0010975,GO:0019901,GO:0030010,GO:0030010,GO:0030036,GO:0030182,GO:0035556,GO:0036503,GO:0043462,GO:0048156,GO:0048471,GO:0050321,GO:0050321,GO:0050321,GO:0050321,GO:0050770,GO:0051117,GO:0051301,GO:0060590,GO:0061178,GO:0061178,GO:0070059,GO:0090176,GO:0106310,GO:0150034,GO:1904152,GO:1904152,GO:2000807 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CEBPA | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | BRSK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | BRSK2 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000035D2F9 | BRSK2 | 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D15B | BRSK2 | 20371350 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004E78D3 | BRSK2 | 20371350 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000055929F | BRSK2 | 20371350 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F72ED | BRSK2 | 20371350 23592263 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VCP | BRSK2 | 23907667 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| KBTBD7 | BRSK2 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| COPS5 | BRSK2 | 22609399 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| FZR1 | BRSK2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKAA1 | BRSK2 | 25348397 | N/A | physical interaction | ComPPI |
| WEE1 | BRSK2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| TRIM25 | BRSK2 | 25348397 | N/A | physical interaction | ComPPI |
| CDC25B | BRSK2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| CDC25C | BRSK2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| PRKACA | BRSK2 | 16870137 23629625 27898060 | N/A | N/A | OmniPath |
| STK11 | BRSK2 | 14976552 18339622 27898060 | stimulant | N/A | OmniPath |
| BRSK2 | WEE1 | 15150265 27898060 | N/A | N/A | OmniPath |
| BRSK2 | CDC25C | 10557092 11333986 11551930 15150265 20068231 27898060 9278512 9543386 | N/A | N/A | OmniPath |
| BRSK2 | PRKAA1 | 21918180 27898060 | stimulant | N/A | OmniPath |