Gene Information gene info

  1. Home

GENE：CASP12

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP12
FullNmae caspase 12 (gene/pseudogene)
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19004
EnsembleID ENSG00000204403
Uniprot Q6UXS9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP12 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP12 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP12 GO:0005737,GO:0005783,GO:0006508,GO:0042981,GO:0097194,GO:0097200

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP12 hsa:100506742 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
CASP12 hsa:100506742 path:hsa04210 Apoptosis - Homo sapiens (human)
CASP12 hsa:100506742 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CASP12 hsa:100506742 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CASP12 hsa:100506742 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
CASP12 hsa:100506742 path:hsa05020 Prion disease - Homo sapiens (human)
CASP12 hsa:100506742 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CASP12 hsa:100506742 path:hsa05161 Hepatitis B - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CASP12 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CASP12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CASP12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CASP12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CASP12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CASP12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 CASP12 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CRYAB CASP12 25348397 N/A physical interaction ComPPI
XIAP CASP12 25348397 N/A physical interaction ComPPI
CASP9 CASP12 25348397 N/A physical interaction ComPPI
HSPA5 CASP12 25348397 N/A physical interaction ComPPI
TRAF2 CASP12 25348397 N/A physical interaction ComPPI
UBE2K CASP12 25348397 N/A physical interaction ComPPI
RIPK2 CASP12 25348397 N/A physical interaction ComPPI
NOD2 CASP12 25348397 N/A physical interaction ComPPI
CASP12 CASP1 16625199 27898060 inhibition N/A OmniPath
CASP12 CASP7 12209154 27898060 stimulant N/A OmniPath
CASP12 CASP9 12097332 15725726 27898060 stimulant N/A OmniPath

Visualization










  Return