GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
CASP5
FullNmae
caspase 5
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:1506
EnsembleID
ENSG00000137757
Uniprot
P51878
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
CASP5
pyroptosis
38538696
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
CASP5
pyroptosis
36341760
The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns.
regulator signature
CASP5
apoptosis
38538696
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
CASP5
apoptosis
36341760
The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns.
regulator signature
Go Annotation:
GeneSymbol
Go id
CASP5
GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0008234,GO:0021762,GO:0042981,GO:0071260,GO:0072558,GO:0072558,GO:0097194,GO:0097200
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
MEFV
CASP5
17431422
23180781
physical association
anti tag coimmunoprecipitation
InnateDB
CASP5
IL18
23180781
9121587
cleavage reaction
protease assay
InnateDB
Source
Target
Pmid
Interactiontype
Methods
Database
TP53
CASP5
18922183
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
SMARCA4
CASP5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CEBPA
CASP5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
CASP5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
GATA2
CASP5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
CASP5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
TAL1
CASP5
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS00002AB575
CASP5
22100165
25416803
mrna cleavage,inhibition
clip
TarBase
URS000023133F
CASP5
22100165
25416803
mrna cleavage,inhibition
clip
TarBase
URS000009A9A2
CASP5
22100165
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000008A99
CASP5
22100165
25416803
mrna cleavage,inhibition
clip
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
PPHLN1
CASP5
25361965
interaction type
N/A
PTMCode2
CASP5
PPHLN1
25361965
interaction type
N/A
PTMCode2
Source
Target
Pmid
Interactiontype
Methods
Database
PPHLN1
CASP5
12853457
14525934
25348397
N/A
experimental interaction detection,physical interaction,in vitro
ComPPI,HPRD
LACRT
CASP5
25348397
N/A
physical interaction
ComPPI
CASP4
CASP5
25348397
N/A
physical interaction
ComPPI
NLRP1
CASP5
12191486
14525934
17418785
24234451
25348397
physical association
anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo
ComPPI,HPRD,IntAct
CASP5
MAX
11535131
14525934
25348397
N/A
experimental interaction detection,in vitro,in vivo
ComPPI,HPRD
CASP5
ARHGAP44
25348397
N/A
physical interaction
ComPPI
CASP5
CASP5
10872455
14525934
N/A
experimental interaction detection
HPRD
CASP1
CASP5
11051551
11432859
11536016
15383541
27898060
inhibition
N/A
OmniPath
NLRP1
CASP5
12191486
17418785
27898060
stimulant
N/A
OmniPath
COP1
CASP5
11051551
11432859
11536016
15383541
27898060
inhibition
N/A
OmniPath
CASP5
MAX
11535131
27898060
N/A
N/A
OmniPath
CASP5
IL1B
17039247
27898060
stimulant
N/A
OmniPath
CARD18
CASP5
11051551
11432859
11536016
15383541
27898060
inhibition
N/A
OmniPath
CASP5
IL18
17039247
27898060
9121587
stimulant
N/A
OmniPath
MEFV
CASP5
17431422
27898060
N/A
N/A
OmniPath
CARD17
CASP5
11051551
11432859
11536016
15383541
27898060
inhibition
N/A
OmniPath
Visualization