Gene Information gene info

GENE:CASP5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP5
FullNmae caspase 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1506
EnsembleID ENSG00000137757
Uniprot P51878

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP5 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP5 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP5 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP5 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP5 GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0008234,GO:0021762,GO:0042981,GO:0071260,GO:0072558,GO:0072558,GO:0097194,GO:0097200

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP5 hsa:838 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CASP5 hsa:838 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MEFV CASP5 17431422 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP5 IL18 23180781 9121587 cleavage reaction protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
TP53 CASP5 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CASP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CASP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CASP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CASP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CASP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002AB575 CASP5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F CASP5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 CASP5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 CASP5 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PPHLN1 CASP5 25361965 interaction type N/A PTMCode2
CASP5 PPHLN1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPHLN1 CASP5 12853457 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LACRT CASP5 25348397 N/A physical interaction ComPPI
CASP4 CASP5 25348397 N/A physical interaction ComPPI
NLRP1 CASP5 12191486 14525934 17418785 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
CASP5 MAX 11535131 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP5 ARHGAP44 25348397 N/A physical interaction ComPPI
CASP5 CASP5 10872455 14525934 N/A experimental interaction detection HPRD
CASP1 CASP5 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath
NLRP1 CASP5 12191486 17418785 27898060 stimulant N/A OmniPath
COP1 CASP5 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath
CASP5 MAX 11535131 27898060 N/A N/A OmniPath
CASP5 IL1B 17039247 27898060 stimulant N/A OmniPath
CARD18 CASP5 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath
CASP5 IL18 17039247 27898060 9121587 stimulant N/A OmniPath
MEFV CASP5 17431422 27898060 N/A N/A OmniPath
CARD17 CASP5 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath

Visualization