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GENE：CASP8AP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP8AP2
FullNmae caspase 8 associated protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1510
EnsembleID ENSG00000118412
Uniprot Q9UKL3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP8AP2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP8AP2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP8AP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP8AP2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP8AP2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP8AP2 GO:0003714,GO:0003714,GO:0005123,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005739,GO:0005739,GO:0006919,GO:0006919,GO:0006919,GO:0007049,GO:0007165,GO:0008625,GO:0008625,GO:0008625,GO:0008656,GO:0016505,GO:0016605,GO:0016605,GO:0032184,GO:0036337,GO:0036337,GO:0045892,GO:0071260,GO:0097190

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR CASP8AP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CASP8AP2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC CASP8AP2 12747840 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CASP8AP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink

Source Target Pmid Interactiontype Methods Database
URS000055128B CASP8AP2 19721136 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000055128B CASP8AP2 19721136 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000028FD1A CASP8AP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000007A060 CASP8AP2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
UBE2I CASP8AP2 19549727 20936779 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach ComPPI,IntAct
TRIM21 CASP8AP2 25348397 N/A physical interaction ComPPI
CALM1 CASP8AP2 25348397 N/A physical interaction ComPPI
BCL2L1 CASP8AP2 25348397 N/A physical interaction ComPPI
SUMO1 CASP8AP2 25348397 N/A physical interaction ComPPI
PIAS1 CASP8AP2 21338522 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
CTBP2 CASP8AP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP8 CASP8AP2 10235259 11340079 14525934 17245429 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
SREBF2 CASP8AP2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TP73 CASP8AP2 25348397 N/A anti tag coimmunoprecipitation ComPPI
FADD CASP8AP2 10235259 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TRAF2 CASP8AP2 11340079 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SP100 CASP8AP2 14525934 17245429 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,imaging technique,in vivo,two hybrid ComPPI,HPRD,IntAct
SUMO2 CASP8AP2 25348397 N/A physical interaction ComPPI
CASP10 CASP8AP2 15069192 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR3C1 CASP8AP2 25348397 N/A physical interaction ComPPI
NR3C2 CASP8AP2 25348397 N/A physical interaction ComPPI
PML CASP8AP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP8AP2 FAS 10235259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP8AP2 CREM 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP8AP2 MX1 25348397 N/A physical interaction ComPPI
CASP8AP2 HDAC1 25348397 N/A physical interaction ComPPI
CASP8AP2 NPAT 17003125 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GLUL CASP8AP2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CASP8AP2 NFKB1 22075988 27898060 stimulant N/A OmniPath
CASP8 CASP8AP2 10235259 11340079 17245429 27898060 stimulant N/A OmniPath
CASP8AP2 CASP8 10235259 11340079 17245429 27898060 stimulant N/A OmniPath
FAS CASP8AP2 10235259 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008C2148 CASP8AP2 25531890 27087310 direct interaction,inhibition N/A NPInter

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