Gene Information gene info

  1. Home

GENE：CD28

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD28
FullNmae CD28 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1653
EnsembleID ENSG00000178562
Uniprot P10747

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD28 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD28 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD28 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD28 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CD28 GO:0001772,GO:0001819,GO:0002020,GO:0002863,GO:0005515,GO:0005829,GO:0005886,GO:0005886,GO:0006366,GO:0006959,GO:0007166,GO:0009897,GO:0009897,GO:0009986,GO:0010628,GO:0010629,GO:0015026,GO:0019901,GO:0031295,GO:0031295,GO:0032733,GO:0032743,GO:0032753,GO:0035739,GO:0042102,GO:0042102,GO:0042102,GO:0042110,GO:0042110,GO:0042110,GO:0042802,GO:0043066,GO:0043491,GO:0045060,GO:0045066,GO:0045070,GO:0045589,GO:0045727,GO:0045840,GO:0045944,GO:0048304,GO:0050852,GO:0051897,GO:0097190,GO:0098636,GO:2000563

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD28 hsa:940 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CD28 hsa:940 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CD28 hsa:940 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
CD28 hsa:940 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
CD28 hsa:940 path:hsa05162 Measles - Homo sapiens (human)
CD28 hsa:940 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
CD28 hsa:940 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
CD28 hsa:940 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
CD28 hsa:940 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
CD28 hsa:940 path:hsa05330 Allograft rejection - Homo sapiens (human)
CD28 hsa:940 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
CD28 hsa:940 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GRB2 CD28 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26192618 26552706 7523569 8551221 9359474 interaction type N/A ACSN
CD86 CD28 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 26192618 7523569 8920882 9359474 interaction type N/A ACSN
FYN CD28 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 26192618 27192565 9738502 interaction type N/A ACSN
CD80 CD28 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26192618 26405600 7512027 7523569 9359474 interaction type N/A ACSN
CTLA4 CD28 10921877 11093160 12370081 16227604 16885030 16916641 18292600 19890961 21159657 21376459 22116087 22437870 26192618 interaction type N/A ACSN
CD28 VAV1 10426994 11034388 11907067 1313950 15197224 15536084 16713974 22437870 23109003 26192618 7523569 9359474 interaction type,chemical activation reaction N/A ACSN,SignaLink
CD28 IL2 10426994 11907067 1313950 15197224 15536084 16713974 22437870 26192618 7523569 9359474 interaction type N/A ACSN
CD28 FLNA 10426994 11907067 1313950 15197224 15536084 16713974 22437870 26192618 7523569 9359474 interaction type N/A ACSN
CD28 MAP3K14 10426994 11907067 1313950 15197224 15536084 16713974 22437870 26192618 7523569 9359474 interaction type N/A ACSN
CD28 LCP2 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26192618 26552706 7523569 8551221 9359474 interaction type N/A ACSN
PIK3R1 CD28 11526404 18641334 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD28 CBLB 12193687 23109003 inhibition N/A SignaLink
CD28 PIK3R1 15790353 16107703 17722974 22315502 23109003 8080844 chemical activation reaction N/A SignaLink
CD28 ITK 15771581 19132916 23109003 9312162 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRAP2 CD28 20005715 interaction type N/A PSP
GRB2 CD28 20005715 interaction type N/A PSP
PIK3R1 CD28 20005715 21071413 8621607 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
AR CD28 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CD28 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CD28 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PGR CD28 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CD28 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CD28 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CD28 10510368 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CD28 16365455 trascriptional regulation,stimulation inferred by curator TFlink
RELA CD28 16365455 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CD28 10510368 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CD28 10510368 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CD28 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00004F4657 CD28 24043548 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001CF056 CD28 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000044FD7 CD28 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 CD28 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 CD28 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 CD28 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CD80 CD28 25361965 interaction type N/A PTMCode2
CD28 CD80 25361965 interaction type N/A PTMCode2
CD4 CD28 25361965 interaction type N/A PTMCode2
CD28 CD4 25361965 interaction type N/A PTMCode2
BMX CD28 25361965 interaction type N/A PTMCode2
CD28 BMX 25361965 interaction type N/A PTMCode2
PIK3R1 CD28 25361965 interaction type N/A PTMCode2
CD28 PIK3R1 25361965 interaction type N/A PTMCode2
DUSP14 CD28 25361965 interaction type N/A PTMCode2
CD28 DUSP14 25361965 interaction type N/A PTMCode2
CD28 CD86 25361965 interaction type N/A PTMCode2
CD86 CD28 25361965 interaction type N/A PTMCode2
CD28 LCK 25361965 interaction type N/A PTMCode2
LCK CD28 25361965 interaction type N/A PTMCode2
CD28 GRB2 25361965 interaction type N/A PTMCode2
GRB2 CD28 25361965 interaction type N/A PTMCode2
CD28 GRAP2 25361965 interaction type N/A PTMCode2
GRAP2 CD28 25361965 interaction type N/A PTMCode2
CD28 PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG CD28 25361965 interaction type N/A PTMCode2
CD28 CD247 25361965 interaction type N/A PTMCode2
CD247 CD28 25361965 interaction type N/A PTMCode2
PIK3R2 CD28 25361965 interaction type N/A PTMCode2
CD28 PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 CD28 14525934 25348397 7509360 8080844 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD4 CD28 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAV1 CD28 25348397 N/A physical interaction ComPPI
PRKCQ CD28 21964608 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PIK3R1 CD28 10820259 14525934 18641334 24234451 25348397 7568038 7584133 7737275 7807015 8146197 8183372 8621607 9417079 association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,competition binding,in vitro,in vivo ComPPI,HPRD,IntAct
DOK1 CD28 25348397 N/A physical interaction ComPPI
GRAP2 CD28 10820259 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
LCK CD28 10430626 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3CG CD28 14525934 25348397 9915850 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRB2 CD28 14525934 24234451 25348397 7584133 7737275 8576157 9694876 association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ITK CD28 10586033 14525934 15144186 25348397 8992971 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CD28 CD247 14525934 25348397 8760790 N/A experimental interaction detection,in vivo ComPPI,HPRD
CD28 CD86 25348397 N/A physical interaction,in vivo,surface plasmon resonance array ComPPI
CD28 LRRC23 1313075 14525934 1847722 25348397 27898060 7523532 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CD28 NSF 11680900 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CD28 PTPRC 1355979 25348397 27898060 N/A in vivo ComPPI,OmniPath
CD28 IL12A 14525934 25348397 27898060 7516408 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CD28 CD80 14525934 21982860 24234451 25348397 7545666 physical association coimmunoprecipitation,experimental interaction detection,protein array,physical interaction ComPPI,HPRD,IntAct
CD28 PIK3CA 25348397 N/A physical interaction ComPPI
DUSP14 CD28 11123293 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CD28 PLCG1 14525934 27898060 8386518 N/A experimental interaction detection HPRD,OmniPath
LCK CD28 10430626 22936936 27898060 8992971 stimulant N/A OmniPath
CD28 GRB2 21487479 24098653 27898060 7584133 7737275 8576157 9694876 stimulant N/A OmniPath
CD28 PIK3R1 10820259 11526404 18641334 19190244 27898060 7568038 7584133 7737275 7807015 8146197 8183372 8621607 9417079 N/A N/A OmniPath
PIK3R1 CD28 10820259 11526404 18641334 19190244 27898060 7568038 7584133 7737275 7807015 8146197 8183372 8621607 9417079 N/A N/A OmniPath
SYK CD28 27898060 8946678 N/A N/A OmniPath
CD28 PIK3CG 18006698 27898060 9915850 stimulant N/A OmniPath
ITK CD28 10586033 15144186 19901323 22936936 27898060 8946678 8992971 stimulant N/A OmniPath

Visualization










  Return