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GENE：CD3E

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD3E
FullNmae CD3 epsilon subunit of T-cell receptor complex
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1674
EnsembleID ENSG00000198851
Uniprot P07766

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD3E immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD3E apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD3E apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CD3E GO:0001772,GO:0001954,GO:0002250,GO:0002669,GO:0002870,GO:0004888,GO:0004888,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0007166,GO:0007166,GO:0007166,GO:0007169,GO:0007172,GO:0007186,GO:0007224,GO:0009897,GO:0009897,GO:0010628,GO:0010629,GO:0016358,GO:0017124,GO:0019722,GO:0019901,GO:0021549,GO:0030159,GO:0031295,GO:0032729,GO:0032743,GO:0032753,GO:0033634,GO:0035739,GO:0042101,GO:0042102,GO:0042105,GO:0042105,GO:0042105,GO:0042105,GO:0042106,GO:0042110,GO:0042608,GO:0042802,GO:0042981,GO:0043197,GO:0044297,GO:0045059,GO:0045060,GO:0045879,GO:0046629,GO:0046631,GO:0050731,GO:0050850,GO:0050852,GO:0065003,GO:0097190,GO:2000563

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD3E hsa:916 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
CD3E hsa:916 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
CD3E hsa:916 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
CD3E hsa:916 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
CD3E hsa:916 path:hsa05142 Chagas disease - Homo sapiens (human)
CD3E hsa:916 path:hsa05162 Measles - Homo sapiens (human)
CD3E hsa:916 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
CD3E hsa:916 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
CD3E hsa:916 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
CD3E hsa:916 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
CD3E hsa:916 path:hsa05340 Primary immunodeficiency - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SNTA1 CD3E 15123239 23180781 physical association peptide array InnateDB
LGALS1 CD3E 10642604 23180781 physical association pull down InnateDB
CD3D CD3E 15084594 23109003 chemical activation reaction N/A SignaLink
CD3G CD3E 15084594 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
EPS8 CD3E 20005715 interaction type N/A PSP
NCK1 CD3E 12110186 18988627 20005715 interaction type N/A PSP,SignaLink
NCK2 CD3E 12110186 20005715 21071413 interaction type N/A PSP,SignaLink
PIK3R1 CD3E 20005715 interaction type N/A PSP
SHC1 CD3E 20005715 interaction type N/A PSP,SignaLink
PIK3R1 CD3E 20005715 20005715 21071413 9312149 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 CD3E 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CD3E 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CD3E 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CD3E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CD3E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CD3E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CD3E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CD3E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CD3E 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ECE9C CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004E02F2 CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC CD3E 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FYN CD3E 22135298 phosphorylation N/A PhosphoSite
NCK1 CD3E 25361965 interaction type N/A PTMCode2
CD3E NCK1 25361965 interaction type N/A PTMCode2
NCK2 CD3E 25361965 interaction type N/A PTMCode2
CD3E NCK2 25361965 interaction type N/A PTMCode2
LCK CD3E 25361965 interaction type N/A PTMCode2
CD3E LCK 25361965 interaction type N/A PTMCode2
CD3E SYK 25361965 interaction type N/A PTMCode2
SYK CD3E 25361965 interaction type N/A PTMCode2
CD3E TOP2B 25361965 interaction type N/A PTMCode2
TOP2B CD3E 25361965 interaction type N/A PTMCode2
CD3E SHC1 25361965 interaction type N/A PTMCode2
SHC1 CD3E 25361965 interaction type N/A PTMCode2
ZAP70 CD3E 25361965 interaction type N/A PTMCode2
CD3E ZAP70 25361965 interaction type N/A PTMCode2
CD3D CD3E 25361965 interaction type N/A PTMCode2
CD3E CD3D 25361965 interaction type N/A PTMCode2
TRAT1 CD3E 25361965 interaction type N/A PTMCode2
CD3E TRAT1 25361965 interaction type N/A PTMCode2
PIK3R1 CD3E 25361965 interaction type N/A PTMCode2
CD3E PIK3R1 25361965 interaction type N/A PTMCode2
EPS8L1 CD3E 25361965 interaction type N/A PTMCode2
CD3E EPS8L1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 CD3E 12110186 14525934 17617578 24234451 25348397 physical association two hybrid,experimental interaction detection,filamentous phage display,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PIK3R2 CD3E 25348397 N/A physical interaction ComPPI
LAT CD3E 25348397 N/A physical interaction ComPPI
SYK CD3E 14525934 24234451 25348397 7761456 9698567 association experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
PIK3R1 CD3E 11689561 11855827 14525934 25348397 9312149 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD38 CD3E 25348397 N/A physical interaction ComPPI
LCK CD3E 11855827 14525934 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SHC1 CD3E 11855827 14525934 24234451 25348397 association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
NCK1 CD3E 12110186 14525934 17617578 18955169 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,filamentous phage display,nuclear magnetic resonance,peptide array,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NCR1 CD3E 24234451 25348397 9625766 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UNC119 CD3E 14525934 14757743 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TRAT1 CD3E 14525934 25348397 9687533 N/A experimental interaction detection,in vivo ComPPI,HPRD
ZAP70 CD3E 11855827 14525934 24234451 25348397 7761456 8366117 association experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN22 CD3E 14525934 16461343 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
POLR1G CD3E 10373416 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD3E CD3D 14525934 20890284 24234451 25348397 9485181 9582308 association anti bait coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
CD3E CD3G 14525934 20890284 2138083 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CD3E TOP2B 14525934 25348397 27898060 8626450 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CD3E CD79B 14525934 25348397 27898060 7541024 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CD3E NCL 11115514 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CD3E JAK3 25348397 N/A physical interaction ComPPI
CD3E CD247 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
CD3E SNTA1 25348397 N/A physical interaction ComPPI
CD3E CSK 25348397 N/A physical interaction ComPPI
CD3E ITPRIPL1 25348397 N/A physical interaction ComPPI
CD3E GHDC 25348397 N/A physical interaction ComPPI
CD3E HLA-A 25348397 N/A physical interaction ComPPI
CD3E LNPEP 25348397 N/A physical interaction ComPPI
CD3E GP1BB 25348397 N/A physical interaction ComPPI
CD3E TM2D3 25348397 N/A physical interaction ComPPI
CD3E FAM241B 25348397 N/A physical interaction ComPPI
CD3E EPS8L1 17617578 18644376 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,filamentous phage display,isothermal titration calorimetry,nuclear magnetic resonance,peptide array,pull down ComPPI,IntAct,OmniPath
CD3E EPS8L3 17617578 24234451 25348397 physical association filamentous phage display ComPPI,IntAct
CD3E EPS8L2 17617578 24234451 25348397 physical association filamentous phage display ComPPI,IntAct
CD3E EPS8 17617578 24234451 25348397 physical association filamentous phage display ComPPI,IntAct
CD3E CCR7 22922463 24234451 25348397 physical association two hybrid ComPPI,IntAct
CD3E MUC15 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD3E ZFPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD3E BNIP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCK CD3E 11855827 27898060 N/A N/A OmniPath
FYN CD3E 17617578 18555270 20005895 27898060 N/A N/A OmniPath

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