GENE：CD5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CD5 |
| FullNmae | CD5 molecule |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1685 |
| EnsembleID | ENSG00000110448 |
| Uniprot | P06127 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CD5 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CD5 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CD5 | GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0008037,GO:0009897,GO:0031295,GO:0038023,GO:0097190 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CD5 | hsa:921 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CD5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | CD5 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | CD5 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F1 | CD5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CD5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CD5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | CD5 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | CD5 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | CD5 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSNK2A1 | CD5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| LCK | CD5 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| FYN | CD5 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| PRKCA | CD5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCG | CD5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CD6 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD6 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | LCK | 25361965 | interaction type | N/A | PTMCode2 |
| CD4 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD4 | 25361965 | interaction type | N/A | PTMCode2 |
| CBL | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CBL | 25361965 | interaction type | N/A | PTMCode2 |
| CD72 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD72 | 25361965 | interaction type | N/A | PTMCode2 |
| ZAP70 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | ZAP70 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD247 | 25361965 | interaction type | N/A | PTMCode2 |
| CD247 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD2 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | PTPN6 | 25361965 | interaction type | N/A | PTMCode2 |
| PTPN6 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD79A | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD79A | 25361965 | interaction type | N/A | PTMCode2 |
| CD27 | CD5 | 25361965 | interaction type | N/A | PTMCode2 |
| CD5 | CD27 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PTPN6 | CD5 | 10082557 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CD4 | CD5 | 14525934 25348397 7539755 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CBL | CD5 | 14525934 23376399 25348397 27898060 9603468 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| VAV1 | CD5 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3R1 | CD5 | 14525934 24234451 25348397 9079809 | association | experimental interaction detection,pull down,surface plasmon resonance,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| PRKCA | CD5 | 11123317 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| LCK | CD5 | 11298344 14525934 15144186 25348397 7513045 | N/A | coimmunoprecipitation,experimental interaction detection,physical interaction,biochemical,in vitro,in vivo | ComPPI,HPRD |
| CD2 | CD5 | 10510361 25348397 27898060 | N/A | physical interaction,in vivo | ComPPI,OmniPath |
| CD72 | CD5 | 14525934 1711157 24234451 25348397 27898060 8806810 | physical association | experimental interaction detection,fluorescence-activated cell sorting,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct,OmniPath |
| CD5 | CSNK2A1 | 14525934 25348397 9834084 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CD5 | CD79A | 14525934 25348397 7512031 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CD5 | CD79B | 14525934 25348397 7512031 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CD5 | FYN | 11298344 14525934 15144186 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CD5 | RASA1 | 14525934 24234451 25348397 9603468 | association | experimental interaction detection,pull down,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| CD5 | ZAP70 | 14525934 25348397 9378960 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CD5 | PRKCB | 11123317 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CD5 | PRKCG | 11123317 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CD5 | CD247 | 1385158 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| CD5 | HNRNPU | 14525934 25348397 9079809 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CD5 | CAMK2D | 14525934 25348397 9692886 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| CD5 | CD6 | 12473675 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| CD5 | PIK3C3 | 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI |
| CD5 | AP2M1 | 14707061 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| DYNLT3 | CD5 | 14525934 25348397 9692886 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| LCK | CD5 | 11298344 11751967 15144186 27898060 7513045 | stimulant | N/A | OmniPath |
| PRKCA | CD5 | 11123317 27898060 9834084 | stimulant | N/A | OmniPath |
| FYN | CD5 | 11298344 11751967 12522270 15144186 15659558 16493040 19605366 23874979 26363459 27898060 | stimulant | N/A | OmniPath |
| PRKCG | CD5 | 11123317 27898060 | stimulant | N/A | OmniPath |
| CSNK2A1 | CD5 | 15174125 19690332 23749302 27898060 9834084 | stimulant | N/A | OmniPath |
| CD5L | CD5 | 27898060 9723705 | N/A | N/A | OmniPath |