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GENE：CD74

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CD74
FullNmae CD74 molecule
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1697
EnsembleID ENSG00000019582
Uniprot P04233

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CD74 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD74 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD74 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CD74 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CD74 GO:0000139,GO:0001516,GO:0001540,GO:0001934,GO:0001961,GO:0001961,GO:0002286,GO:0002606,GO:0002792,GO:0002830,GO:0002906,GO:0004896,GO:0004896,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005765,GO:0005771,GO:0005773,GO:0005886,GO:0005886,GO:0006886,GO:0009897,GO:0009986,GO:0009986,GO:0010628,GO:0012507,GO:0016020,GO:0016020,GO:0016064,GO:0019882,GO:0019883,GO:0019886,GO:0019955,GO:0023026,GO:0030336,GO:0030658,GO:0030666,GO:0030669,GO:0030890,GO:0031394,GO:0032588,GO:0032722,GO:0032755,GO:0032757,GO:0032991,GO:0033674,GO:0033674,GO:0034341,GO:0035691,GO:0035692,GO:0035693,GO:0035718,GO:0035718,GO:0042289,GO:0042289,GO:0042289,GO:0042609,GO:0042613,GO:0042658,GO:0042802,GO:0043030,GO:0043066,GO:0043123,GO:0043202,GO:0043410,GO:0043518,GO:0043518,GO:0044183,GO:0045058,GO:0045059,GO:0045060,GO:0045581,GO:0045582,GO:0045657,GO:0045893,GO:0046598,GO:0048146,GO:0050731,GO:0050731,GO:0050998,GO:0051085,GO:0060907,GO:0060907,GO:0065003,GO:0070062,GO:0070206,GO:0070374,GO:0070374,GO:0070374,GO:0090023,GO:0098553,GO:1902166,GO:1902166,GO:2000343,GO:2000448

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CD74 hsa:972 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
CD74 hsa:972 path:hsa05152 Tuberculosis - Homo sapiens (human)
CD74 hsa:972 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MIF CD74 10878343 12782713 12803886 16181339 16283355 18490733 20861157 23390297 26192618 8195715 9637476 association N/A ACSN
CTSS CD74 10072073 10562280 16286017 22157818 22424724 26192618 interaction type N/A ACSN
LGMN CD74 10795737 12705852 12776207 16181339 17204652 26192618 interaction type N/A ACSN
HMGB1 CD74 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
FLT3LG CD74 10477595 14670306 15749884 16418395 16713974 17404308 20547845 25215878 26192618 8920882 9268501 interaction type N/A ACSN
TNF CD74 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26192618 26201938 8910423 interaction type N/A ACSN
STAT1 CD74 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 26192618 6357187 7594497 8683106 8871614 interaction type N/A ACSN
AP2A1 CD74 15749704 15911768 26192618 interaction type N/A ACSN
AP2A2 CD74 15749704 15911768 26192618 interaction type N/A ACSN
AP2B1 CD74 15749704 15911768 26192618 interaction type N/A ACSN
AP2M1 CD74 15749704 15911768 26192618 interaction type N/A ACSN
AP2S1 CD74 15749704 15911768 26192618 interaction type N/A ACSN
CIITA CD74 18437201 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF8 CD74 22096565 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP CD74 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 CD74 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NFKB1 CD74 8164652 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
REL CD74 8164652 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
RELA CD74 8164652 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 CD74 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CD74 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CD74 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CD74 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CD74 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CD74 MIF 25361965 interaction type N/A PTMCode2
MIF CD74 25361965 interaction type N/A PTMCode2
CD74 CD44 25361965 interaction type N/A PTMCode2
CD44 CD74 25361965 interaction type N/A PTMCode2
CD74 CTSL 25361965 interaction type N/A PTMCode2
CTSL CD74 25361965 interaction type N/A PTMCode2
CD74 CD1D 25361965 interaction type N/A PTMCode2
CD1D CD74 25361965 interaction type N/A PTMCode2
CD74 HLA-DRA 25361965 interaction type N/A PTMCode2
HLA-DRA CD74 25361965 interaction type N/A PTMCode2
CD74 CXCR4 25361965 interaction type N/A PTMCode2
CXCR4 CD74 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CTSL CD74 10022822 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HLA-DPB1 CD74 14525934 16242130 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CD44 CD74 14525934 24234451 25348397 27898060 29190904 8343954 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct,OmniPath
UBE2N CD74 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
HSPA1A CD74 17357109 24234451 24428437 25348397 physical association solid phase assay ComPPI,IntAct
HLA-DQB1 CD74 14525934 16242130 17629515 24234451 25348397 physical association experimental interaction detection,in vivo,solid phase assay ComPPI,HPRD,IntAct
CD1D CD74 11754812 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
UBA1 CD74 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
CXCR4 CD74 19665027 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
COPG2 CD74 25348397 N/A physical interaction ComPPI
COPG1 CD74 25348397 N/A physical interaction ComPPI
UBE2V1 CD74 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
CD74 HLA-DPA1 14525934 16242130 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CD74 HLA-DQA1 14525934 16242130 24234451 25241761 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CD74 HLA-DRA 14525934 16242130 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CD74 HLA-DMB 25348397 N/A in vivo ComPPI
CD74 CTSF 10748235 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CD74 APP 25348397 N/A physical interaction ComPPI
CD74 HADHA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CD74 LAMTOR5 25348397 N/A physical interaction ComPPI
CD74 MAP3K1 25348397 N/A physical interaction ComPPI
CD74 TM4SF20 25348397 N/A physical interaction ComPPI
CD74 HLA-DMA 21131964 24234451 25348397 association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
MIF CD74 12782713 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CD74 CD74 14525934 9752000 9843486 N/A experimental interaction detection HPRD
CCR1 CD74 24234451 28298427 physical association ubiquitin reconstruction IntAct
CD74 YWHAH 27898060 9448284 N/A N/A OmniPath
CD74 HLA-DRB1 2391366 27898060 N/A N/A OmniPath
CD74 CXCR4 19665027 27898060 stimulant N/A OmniPath
APP CD74 19849849 21832049 27898060 N/A N/A OmniPath
MAPK3 CD74 2507633 27898060 N/A N/A OmniPath
CD74 LGMN 14966190 27898060 N/A N/A OmniPath
MIF CD74 12782713 27898060 stimulant N/A OmniPath

Visualization










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