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GENE：MKNK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MKNK1
FullNmae MAPK interacting serine/threonine kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7110
EnsembleID ENSG00000079277
Uniprot Q9BUB5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MKNK1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MKNK1 GO:0004674,GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006417,GO:0006468,GO:0009931,GO:0018105,GO:0018105,GO:0035556,GO:0035556,GO:0046777,GO:0046872,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MKNK1 hsa:8569 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MKNK1 hsa:8569 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
MKNK1 hsa:8569 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MKNK1 EIF4E 10022874 11463832 18775330 23331499 26192618 9155017 9604935 9878069 interaction type,stimulation N/A ACSN,SignaLink
EIF4E MKNK1 23180781 9878069 physical association anti tag coimmunoprecipitation InnateDB
EIF4G1 MKNK1 23180781 9878069 physical association anti tag coimmunoprecipitation InnateDB
EIF4G2 MKNK1 23180781 9878069 physical association anti tag coimmunoprecipitation InnateDB
MAPK14 MKNK1 11157753 23180781 23331499 9155018 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
MAPK3 MKNK1 23331499 9155018 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MKNK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 MKNK1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MKNK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MKNK1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MKNK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MKNK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC MKNK1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 MKNK1 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 MKNK1 22135298 phosphorylation N/A PhosphoSite
MAPK14 MKNK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 MKNK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MKNK1 PNPLA8 22135298 phosphorylation N/A PhosphoSite
MKNK1 SFPQ 22135298 phosphorylation N/A PhosphoSite
MKNK1 HNRNPA1 22135298 phosphorylation N/A PhosphoSite
MKNK1 SPRY2 22135298 phosphorylation N/A PhosphoSite
MKNK1 EIF4E 22135298 phosphorylation N/A PhosphoSite
MKNK1 MAPK1 25361965 interaction type N/A PTMCode2
EIF4G3 MKNK1 25361965 interaction type N/A PTMCode2
MKNK1 EIF4G3 25361965 interaction type N/A PTMCode2
MKNK1 MAPK14 25361965 interaction type N/A PTMCode2
EIF4G1 MKNK1 25361965 interaction type N/A PTMCode2
MKNK1 EIF4G1 25361965 interaction type N/A PTMCode2
PLA2G4A MKNK1 25361965 interaction type N/A PTMCode2
MKNK1 PLA2G4A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SPRY2 MKNK1 25348397 N/A physical interaction ComPPI
PAK2 MKNK1 14525934 15234964 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
UBE2D1 MKNK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AB1 MKNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAPK1 MKNK1 14525934 24234451 25348397 9155017 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKDC MKNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAPK3 MKNK1 14525934 25348397 9155018 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CREBBP MKNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EIF4G1 MKNK1 24234451 25348397 9878069 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK14 MKNK1 14525934 20936779 23455922 23602568 24234451 25348397 9155018 association,physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,tandem affinity purification ComPPI,HPRD,IntAct
HGS MKNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP2CA MKNK1 20927323 24234451 25348397 physical association phosphatase assay ComPPI,IntAct
PARD6B MKNK1 25348397 N/A physical interaction ComPPI
RAB5A MKNK1 25348397 N/A physical interaction ComPPI
XPO1 MKNK1 25348397 N/A physical interaction ComPPI
DNAJC7 MKNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HIPK2 MKNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNIP2 MKNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATXN3 MKNK1 25348397 N/A two hybrid,physical interaction ComPPI
ID1 MKNK1 25348397 N/A physical interaction ComPPI
PDK1 MKNK1 25348397 N/A physical interaction ComPPI
PPIA MKNK1 25348397 N/A physical interaction ComPPI
TRIM25 MKNK1 25348397 N/A physical interaction ComPPI
EIF4G2 MKNK1 25348397 N/A physical interaction ComPPI
KIF1C MKNK1 25348397 N/A physical interaction ComPPI
EIF4E MKNK1 10022874 14525934 24234451 25348397 9155017 9878069 physical association coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
PHAX MKNK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK11 MKNK1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EIF4G3 MKNK1 10022874 14525934 21900206 24234451 25348397 9878069 physical association two hybrid,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
MYH13 MKNK1 25348397 N/A physical interaction ComPPI
DDAH2 MKNK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RCN3 MKNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DMBX1 MKNK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KIF18A MKNK1 25348397 N/A physical interaction ComPPI
APP MKNK1 25348397 N/A physical interaction ComPPI
FANCA MKNK1 25348397 N/A physical interaction ComPPI
MOV10 MKNK1 25348397 N/A physical interaction ComPPI
MKNK1 LLGL2 25348397 N/A physical interaction ComPPI
MKNK1 RNASEH2B 25348397 N/A physical interaction ComPPI
MKNK1 BOD1L1 25348397 N/A physical interaction ComPPI
MKNK1 PLA2G4A 10978317 14525934 8636128 9468497 N/A experimental interaction detection HPRD
MKNK1 MKNK1 14525934 9878069 N/A experimental interaction detection HPRD
MKNK1 MBP 14525934 9155018 N/A experimental interaction detection HPRD
MKNK1 SFPQ 17965020 27898060 N/A N/A OmniPath
MAPK3 MKNK1 27898060 9155017 9155018 stimulant N/A OmniPath
MAPK14 MKNK1 11157753 17130135 17689282 19574459 20936779 23455922 23602568 26186194 27898060 9155017 9155018 stimulant N/A OmniPath
MKNK1 EIF4G2 27898060 9878069 N/A N/A OmniPath
EIF4G1 MKNK1 15234964 27898060 9878069 N/A N/A OmniPath
MKNK1 EIF4G1 15234964 27898060 9878069 stimulant N/A OmniPath
MAPK1 MKNK1 27898060 9155017 stimulant N/A OmniPath
PPP2CA MKNK1 20927323 27898060 inhibition N/A OmniPath
PAK2 MKNK1 15234964 25241761 27898060 inhibition,stimulant N/A OmniPath
EIF4E MKNK1 10022874 11463832 27898060 9155017 9878069 N/A N/A OmniPath
MKNK1 EIF4E 10022874 11154262 11463832 11606200 11723111 15574771 16540463 16720573 17724079 20626350 21635931 25915158 25921059 25923732 27898060 7782323 9155017 9878069 stimulant N/A OmniPath
MKNK1 HNRNPA1 16111636 27898060 N/A N/A OmniPath
MKNK1 SPRY2 16479008 19690147 19864419 27898060 inhibition,stimulant N/A OmniPath
MKNK1 PLA2G4A 10978317 16964243 18212344 18669648 19664994 20068231 27898060 8636128 9468497 stimulant N/A OmniPath
MKNK1 PNPLA8 23258543 25492867 27898060 N/A N/A OmniPath

Visualization










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