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GENE：NR0B2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NR0B2
FullNmae nuclear receptor subfamily 0 group B member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7961
EnsembleID ENSG00000131910
Uniprot Q15466

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NR0B2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NR0B2 GO:0000122,GO:0000785,GO:0000785,GO:0003714,GO:0003714,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0007219,GO:0007623,GO:0007623,GO:0008134,GO:0008203,GO:0009749,GO:0010628,GO:0010629,GO:0014070,GO:0015721,GO:0019904,GO:0031100,GO:0032024,GO:0032922,GO:0042803,GO:0042975,GO:0043231,GO:0043433,GO:0043433,GO:0044877,GO:0045471,GO:0045892,GO:0045893,GO:0046965,GO:0046966,GO:0140416

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NR0B2 hsa:8431 path:hsa04976 Bile secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NR0B2 USF1 21725320 23180781 physical association anti tag coimmunoprecipitation InnateDB
NR0B2 ABCB11 23180781 25675114 physical association anti tag coimmunoprecipitation InnateDB
NR0B2 HNF4A 10594021 15604093 20516075 21071413 23331499 stimulation N/A SignaLink,SignaLink
ESR1 NR0B2 10648597 21071413 23331499 9773978 stimulation N/A SignaLink,SignaLink
NR0B2 ESR1 11861507 18988627 21071413 23331499 9773978 stimulation N/A SignaLink,SignaLink
NR0B2 SIRT1 20375098 interaction type,stimulation N/A SignaLink
NR0B2 ONECUT1 18459945 interaction type,inhibition N/A SignaLink
NR0B2 RXRA 10594021 23331499 stimulation N/A SignaLink
NR0B2 NR5A2 11030331 12198243 20375098 20516075 21566081 23331499 stimulation N/A SignaLink
NR0B2 RXRB 10594021 10845098 23331499 stimulation N/A SignaLink
ESR2 NR0B2 10648597 23331499 stimulation N/A SignaLink
NR0B2 NR1I2 12805410 23331499 stimulation N/A SignaLink
NR0B2 THRA 11368516 23331499 stimulation N/A SignaLink
NR0B2 THRB 11368516 23331499 stimulation N/A SignaLink
NR0B2 RARA 11368516 23331499 stimulation N/A SignaLink
NR0B2 RARB 11368516 23331499 stimulation N/A SignaLink
NR0B2 PPARA 11369442 23331499 stimulation N/A SignaLink
NR0B2 NR1H2 12198243 23331499 stimulation N/A SignaLink
NR0B2 NR1H3 12198243 23331499 stimulation N/A SignaLink
NR0B2 NR1I3 14963109 15000748 23331499 8650544 9773978 stimulation N/A SignaLink
NR0B2 ESR2 10648597 23331499 9773978 stimulation N/A SignaLink
NR0B2 ESRRB 11705994 23331499 stimulation N/A SignaLink
NR0B2 ESRRG 11705994 14963109 20516075 21459093 23331499 stimulation N/A SignaLink
NR0B2 ESRRA 11705994 15604093 23331499 stimulation N/A SignaLink
NR0B2 AR 11735420 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 NR0B2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NR0B2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 NR0B2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1H4 NR0B2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TBP NR0B2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NR0B2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF6 NR0B2 18450959 trascriptional regulation,stimulation inferred by curator TFlink
CLOCK NR0B2 20674862 trascriptional regulation,stimulation inferred by curator TFlink
EP300 NR0B2 18842595 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 NR0B2 15123650 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 NR0B2 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN NR0B2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 NR0B2 22314666 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000003E1A9 NR0B2 22314666 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000003ABC4 NR0B2 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKCZ NR0B2 22135298 phosphorylation N/A PhosphoSite
NR0B2 SMARCA2 25361965 interaction type N/A PTMCode2
SMARCA2 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 ONECUT1 25361965 interaction type N/A PTMCode2
ONECUT1 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 HNF4A 25361965 interaction type N/A PTMCode2
HNF4A NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 GPS2 25361965 interaction type N/A PTMCode2
GPS2 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 NR1H3 25361965 interaction type N/A PTMCode2
NR1H3 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 NR1I3 25361965 interaction type N/A PTMCode2
NR1I3 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 NCOA3 25361965 interaction type N/A PTMCode2
NCOA3 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 NR5A1 25361965 interaction type N/A PTMCode2
NR5A1 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 SP2 25361965 interaction type N/A PTMCode2
SP2 NR0B2 25361965 interaction type N/A PTMCode2
NR0B2 RXRA 25361965 interaction type N/A PTMCode2
RXRA NR0B2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GPSM3 NR0B2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNW1 NR0B2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SMARCE1 NR0B2 25348397 N/A physical interaction ComPPI
RARA NR0B2 14525934 25348397 9773978 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
SMARCC1 NR0B2 25348397 N/A physical interaction ComPPI
RXRG NR0B2 25348397 N/A physical interaction ComPPI
TRAF6 NR0B2 25348397 N/A physical interaction ComPPI
SMAD4 NR0B2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PEF1 NR0B2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EHMT2 NR0B2 25348397 N/A physical interaction ComPPI
DDX20 NR0B2 14525934 14963109 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
AR NR0B2 11735420 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RUNX2 NR0B2 25348397 N/A physical interaction ComPPI
VDR NR0B2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NCOA3 NR0B2 25348397 N/A physical interaction ComPPI
HDAC3 NR0B2 17895379 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PIAS1 NR0B2 25348397 N/A physical interaction ComPPI
ZAP70 NR0B2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PLSCR1 NR0B2 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
THRA NR0B2 25348397 N/A physical interaction ComPPI
NR1H3 NR0B2 12198243 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NR1I2 NR0B2 25348397 N/A physical interaction ComPPI
NR1I3 NR0B2 14525934 14963109 25348397 8650544 9773978 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SIN3A NR0B2 25348397 N/A physical interaction ComPPI
PPARG NR0B2 11696534 14525934 19596656 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
CILK1 NR0B2 25348397 N/A physical interaction ComPPI
PPARD NR0B2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SMARCB1 NR0B2 25348397 N/A physical interaction ComPPI
EID1 NR0B2 14525934 14963109 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
NR1H2 NR0B2 12198243 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CHRD NR0B2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR0B2 RXRB 10594021 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NR0B2 ESR2 10648597 14525934 25348397 9773978 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
NR0B2 NR5A2 11668176 14525934 14963109 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD
NR0B2 HNF4A 16488887 24234451 25348397 physical association two hybrid,physical interaction,lexa b52 complementation ComPPI,IntAct
NR0B2 ESRRG 14525934 14963109 21459093 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NR0B2 ESRRA 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NR0B2 HNF4G 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NR0B2 ESR1 11861507 14525934 25348397 9773978 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NR0B2 RXRA 10594021 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
NR0B2 POLR2A 25348397 N/A physical interaction ComPPI
NR0B2 SP2 25348397 N/A physical interaction ComPPI
NR0B2 KLF6 25348397 N/A physical interaction ComPPI
NR0B2 PAX9 25348397 N/A physical interaction ComPPI
NR0B2 XBP1 25348397 N/A physical interaction ComPPI
NR0B2 ONECUT1 18459945 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NR0B2 HDAC1 17895379 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NR0B2 HDAC6 25348397 N/A physical interaction ComPPI
NR0B2 SMARCA2 25348397 N/A physical interaction ComPPI
NR0B2 SIRT1 20375098 21081708 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
NR0B2 SIRT6 25348397 N/A physical interaction ComPPI
NR0B2 SIRT7 25348397 N/A physical interaction ComPPI
NR0B2 RARG 14525934 15604093 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
NR0B2 MDM2 22197810 22575647 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
NR0B2 TP53 22575647 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NR0B2 GPS2 17895379 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
NR0B2 RNF31 25348397 N/A physical interaction ComPPI
NR0B2 IL3RA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR0B2 ZMYND10 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR0B2 FN1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR0B2 HNRNPA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR0B2 NEUROD1 25348397 N/A physical interaction ComPPI
NR0B2 ID2 25348397 N/A physical interaction ComPPI
NR0B2 VCPIP1 25348397 N/A physical interaction ComPPI
NR0B2 NR3C1 25348397 N/A physical interaction ComPPI
NR0B2 CIDEC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RBP5 NR0B2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR0B2 PPARA 11369442 27898060 stimulant N/A OmniPath
NR0B2 NR1I3 14963109 15000748 27898060 8650544 9773978 inhibition N/A OmniPath
ESR1 NR0B2 10648597 11861507 27898060 9773978 stimulant N/A OmniPath
NR0B2 ESR1 10648597 11861507 27898060 9773978 inhibition,stimulant N/A OmniPath
NR0B2 NR1I2 12805410 27898060 inhibition,stimulant N/A OmniPath
NR0B2 RARA 11368516 27898060 8650544 9773978 stimulant N/A OmniPath
PRKCZ NR0B2 23824184 27898060 N/A N/A OmniPath
NR0B2 RXRA 10594021 12198243 21988832 27898060 stimulant N/A OmniPath
NR0B2 AR 11735420 27898060 inhibition,stimulant N/A OmniPath
NR0B2 CEBPA 17094771 27898060 inhibition N/A OmniPath
NR0B2 NR5A2 11030331 11668176 12198243 14963109 15723037 20375098 20516075 21262773 21566081 22504882 27898060 inhibition,stimulant N/A OmniPath
NR0B2 NR1H2 12198243 27898060 stimulant N/A OmniPath
NR0B2 RXRB 10594021 108451 27898060 stimulant N/A OmniPath
NR0B2 THRA 11368516 27898060 stimulant N/A OmniPath
NR0B2 ESR2 10648597 27898060 9773978 stimulant N/A OmniPath
ESR2 NR0B2 10648597 27898060 9773978 stimulant N/A OmniPath
NR0B2 HNF4A 10594021 15604093 16488887 20516075 27898060 stimulant N/A OmniPath
NR0B2 ESRRG 11705994 14963109 20516075 21459093 27898060 stimulant N/A OmniPath
NR0B2 THRB 11368516 27898060 stimulant N/A OmniPath
NR0B2 NR1H3 12198243 27898060 stimulant N/A OmniPath
NR0B2 RARB 11368516 27898060 stimulant N/A OmniPath

Visualization










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