GENE：CSF2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CSF2 |
| FullNmae | colony stimulating factor 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2434 |
| EnsembleID | ENSG00000164400 |
| Uniprot | P04141 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CSF2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CSF2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CSF2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CSF2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CSF2 | GO:0001821,GO:0001892,GO:0005125,GO:0005125,GO:0005129,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005886,GO:0006955,GO:0007259,GO:0008083,GO:0008283,GO:0008284,GO:0010628,GO:0010744,GO:0030099,GO:0030223,GO:0030224,GO:0030225,GO:0030335,GO:0030526,GO:0032747,GO:0034021,GO:0034405,GO:0038157,GO:0042045,GO:0042531,GO:0043011,GO:0043231,GO:0045187,GO:0045892,GO:0070665,GO:0071222,GO:0071803,GO:0097011,GO:0097028,GO:2001240 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CSF2 | hsa:1437 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| CSF2 | hsa:1437 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSF2 | CSF2RA | 10572088 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 23331499 24030977 24091328 26192618 27216177 | interaction type,stimulation | N/A | ACSN,SignaLink |
| CSF2 | CSF2RB | 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 26192618 27216177 | interaction type | N/A | ACSN |
| JAK2 | CSF2 | 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 26192618 27216177 | interaction type | N/A | ACSN |
| CSF2 | IL4R | 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845 26192618 | interaction type | N/A | ACSN |
| CSF2 | STAT1 | 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 26192618 27216177 | interaction type | N/A | ACSN |
| CSF2 | STAT6 | 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 26192618 27216177 | interaction type | N/A | ACSN |
| CSF2 | IKBKG | 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845 26192618 | interaction type | N/A | ACSN |
| CSF2 | IRF5 | 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845 26192618 | interaction type | N/A | ACSN |
| CSF2 | HIF1A | 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845 26192618 | interaction type | N/A | ACSN |
| KIR2DS2 | CSF2 | 11015446 12731048 20814939 23715743 24586048 26192618 9490415 9625766 9655483 | interaction type | N/A | ACSN |
| CSF2 | REL | 23180781 8934574 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CSF2 | RELA | 18230685 23180781 8934574 9190901 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| NFKB1 | CSF2 | 23180781 8934574 9190901 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CSF2 | HMGA1 | 23180781 8934574 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CSF2 | JUN | 23180781 9190901 | physical association | electrophoretic mobility supershift assay | InnateDB |
| FOS | CSF2 | 23180781 9190901 9862439 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CSF2 | CREM | 23180781 9545284 | physical association | electrophoretic mobility supershift assay | InnateDB |
| RUNX1 | CSF2 | 20506188 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMARCA4 | CSF2 | 20506188 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMARCB1 | CSF2 | 20506188 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HNRNPD | CSF2 | 16273101 17082615 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HNRNPC | CSF2 | 16273101 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ELAVL1 | CSF2 | 17082615 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CSF2 | NR3C1 | 11509589 23180781 | physical association | electrophoretic mobility shift assay | InnateDB |
| CSF2 | NFATC1 | 16498406 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CSF2 | POU2F1 | 16498406 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CSF2RA | CSF2 | 10572088 23180781 | physical association | saturation binding | InnateDB |
| PRG2 | CSF2 | 23180781 7727786 | physical association | cosedimentation in solution | InnateDB |
| SDC2 | CSF2 | 10734053 23180781 | physical association | ion exchange chromatography | InnateDB |
| CSF2 | ILF3 | 12565831 23180781 | physical association | affinity chromatography technology | InnateDB |
| CSF2 | SYNCRIP | 12565831 23180781 | physical association | affinity chromatography technology | InnateDB |
| CSF2 | ILF2 | 12565831 23180781 | physical association | affinity chromatography technology | InnateDB |
| CSF2 | HNRNPA1 | 12565831 23180781 | physical association | affinity chromatography technology | InnateDB |
| CSF2 | HNRNPA2B1 | 12565831 23180781 | physical association | affinity chromatography technology | InnateDB |
| CSF2 | HNRNPA0 | 12565831 23180781 | physical association | affinity chromatography technology | InnateDB |
| CSF2 | PABPC1 | 12565831 23180781 | physical association | affinity chromatography technology | InnateDB |
| CSF2 | CSF3R | 16492764 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CSF2 | 12475968 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CSF2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CSF2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| NFKB1 | CSF2 | 18285351 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | CSF2 | 15840658 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFAM1 | CSF2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | CSF2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CSF2 | 18971253 19158269 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CSF2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CSF2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CSF2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | CSF2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREBBP | CSF2 | 20439113 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS2 | CSF2 | 12646185 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | CSF2 | 18285351 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | CSF2 | 20439113 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU2F1 | CSF2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| REL | CSF2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KITLG | CSF2 | 25361965 | interaction type | N/A | PTMCode2 |
| CSF2 | KITLG | 25361965 | interaction type | N/A | PTMCode2 |
| CSF2 | SDC2 | 25361965 | interaction type | N/A | PTMCode2 |
| SDC2 | CSF2 | 25361965 | interaction type | N/A | PTMCode2 |
| CSF2 | IL3RA | 25361965 | interaction type | N/A | PTMCode2 |
| IL3RA | CSF2 | 25361965 | interaction type | N/A | PTMCode2 |
| CSF2 | CSF3R | 25361965 | interaction type | N/A | PTMCode2 |
| CSF3R | CSF2 | 25361965 | interaction type | N/A | PTMCode2 |
| CSF2 | CSF2RB | 25361965 | interaction type | N/A | PTMCode2 |
| CSF2RB | CSF2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MEOX2 | CSF2 | 24234451 25348397 25416956 25910212 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid | ComPPI,IntAct |
| CSF2 | CSF2RB | 14525934 18692472 24234451 25348397 2645577 8278375 | physical association | cross-linking study,experimental interaction detection,x-ray crystallography,physical interaction,biochemical,saturation binding,in vitro,in vivo | ComPPI,HPRD,IntAct |
| CSF2 | SDC2 | 10734053 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CSF2 | KITLG | 12421569 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CSF2 | CSF2RA | 10572088 14525934 1702217 18692472 24234451 25348397 8910448 9211889 | physical association | experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,biochemical,in vitro,in vivo | ComPPI,HPRD,IntAct |
| CSF2 | IL3RA | 14525934 25348397 7957082 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CSF2 | PRG2 | 14525934 25348397 27898060 7727786 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CSF2 | PABPC1 | 25348397 | N/A | physical interaction | ComPPI |
| CSF2 | HNRNPA0 | 25348397 | N/A | physical interaction | ComPPI |
| CSF2 | HNRNPA2B1 | 25348397 | N/A | physical interaction | ComPPI |
| CSF2 | HNRNPA1 | 25348397 | N/A | physical interaction | ComPPI |
| CSF2 | SYNCRIP | 25348397 | N/A | physical interaction | ComPPI |
| CSF2 | ILF3 | 25348397 | N/A | physical interaction | ComPPI |
| CSF2 | CSF3R | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| ILF2 | CSF2 | 25348397 | N/A | physical interaction | ComPPI |
| CSF2 | CSF2 | 14525934 1702217 8910448 9211889 | N/A | experimental interaction detection | HPRD |
| CSF2 | CSF2RA | 10572088 10753826 1702217 18551128 2555171 2645577 27898060 2828352 7957082 8910448 9187659 9211889 | stimulant | N/A | OmniPath |
| CSF2 | CSF3R | 11091218 11468284 16492764 27898060 7691413 | stimulant | N/A | OmniPath |
| SPI1 | CSF2 | 15676205 27898060 | stimulant | N/A | OmniPath |