GENE：CTH
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CTH |
| FullNmae | cystathionine gamma-lyase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2501 |
| EnsembleID | ENSG00000116761 |
| Uniprot | P32929 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CTH | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTH | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTH | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTH | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CTH | GO:0004123,GO:0004123,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0006534,GO:0006629,GO:0018272,GO:0019343,GO:0019343,GO:0019344,GO:0019346,GO:0019346,GO:0030170,GO:0030170,GO:0030968,GO:0042802,GO:0043123,GO:0044524,GO:0044540,GO:0047982,GO:0051289,GO:0070062,GO:0070814,GO:0070814,GO:0080146,GO:0098606,GO:1904831,GO:1990830,GO:2001234 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CTH | hsa:1491 | path:hsa00260 | Glycine, serine and threonine metabolism - Homo sapiens (human) |
| CTH | hsa:1491 | path:hsa00270 | Cysteine and methionine metabolism - Homo sapiens (human) |
| CTH | hsa:1491 | path:hsa00450 | Selenocompound metabolism - Homo sapiens (human) |
| CTH | hsa:1491 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| CTH | hsa:1491 | path:hsa01230 | Biosynthesis of amino acids - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CTH | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | CTH | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | CTH | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | CTH | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CTH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | CTH | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000F31F4 | CTH | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | CTH | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | CTH | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00005ACA7C | CTH | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002AAD6B | CTH | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000078918 | CTH | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000047A67D | CTH | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00005194EC | CTH | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SPRY2 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| SGTA | CTH | 25348397 | N/A | physical interaction | ComPPI |
| NUTF2 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| RECK | CTH | 25348397 | N/A | physical interaction | ComPPI |
| CTBP1 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| DUT | CTH | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | CTH | 15161933 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| PFKM | CTH | 25348397 | N/A | physical interaction | ComPPI |
| DLD | CTH | 25348397 | N/A | physical interaction | ComPPI |
| SERPINB8 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| SDC1 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| SDCBP2 | CTH | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| TP53RK | CTH | 25348397 | N/A | physical interaction | ComPPI |
| FDPS | CTH | 25348397 | N/A | physical interaction | ComPPI |
| FGB | CTH | 25348397 | N/A | physical interaction | ComPPI |
| CAPN2 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| PREP | CTH | 25348397 | N/A | physical interaction | ComPPI |
| WDR1 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| LUM | CTH | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| ACLY | CTH | 25348397 | N/A | physical interaction | ComPPI |
| NTAQ1 | CTH | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ENO2 | CTH | 25348397 | N/A | physical interaction | ComPPI |
| CBS | CTH | 25348397 | N/A | physical interaction | ComPPI |
| ATIC | CTH | 25348397 | N/A | physical interaction | ComPPI |
| CTH | PTMA | 25348397 | N/A | physical interaction | ComPPI |
| CTH | FOLH1 | 25348397 | N/A | physical interaction | ComPPI |
| CTH | PAPSS2 | 25348397 | N/A | physical interaction | ComPPI |
| CTH | GAPDHS | 25348397 | N/A | physical interaction | ComPPI |
| CTH | PTCRA | 25348397 | N/A | physical interaction | ComPPI |
| CTH | GHITM | 25348397 | N/A | physical interaction | ComPPI |
| PRKG2 | CTH | 25900831 27898060 | N/A | N/A | OmniPath |