GENE：CTSC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CTSC |
| FullNmae | cathepsin C |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2528 |
| EnsembleID | ENSG00000109861 |
| Uniprot | P53634 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CTSC | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| CTSC | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CTSC | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTSC | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTSC | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTSC | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CTSC | GO:0001913,GO:0004197,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005654,GO:0005764,GO:0005764,GO:0005764,GO:0005788,GO:0005813,GO:0006508,GO:0006915,GO:0006955,GO:0008234,GO:0008239,GO:0010033,GO:0016020,GO:0016505,GO:0019902,GO:0030134,GO:0031404,GO:0031642,GO:0033116,GO:0035578,GO:0042802,GO:0043231,GO:0043621,GO:0051087,GO:0051603,GO:0062023,GO:0070062,GO:1903052,GO:1903980,GO:2001235 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CTSC | hsa:1075 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| CTSC | hsa:1075 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CTSC | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CTSC | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | CTSC | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | CTSC | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CTSC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | CTSC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTSL | CTSC | 11327826 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CEP43 | CTSC | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| WFDC9 | CTSC | 25348397 | N/A | physical interaction | ComPPI |
| RBM8A | CTSC | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MAPK8 | CTSC | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CD81 | CTSC | 25348397 | N/A | physical interaction | ComPPI |
| XRN2 | CTSC | 25348397 | N/A | physical interaction | ComPPI |
| SAE1 | CTSC | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| UBA2 | CTSC | 25348397 | N/A | physical interaction | ComPPI |
| CAPN1 | CTSC | 12358155 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| ARIH1 | CTSC | 25348397 | N/A | physical interaction | ComPPI |
| CST7 | CTSC | 18256700 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| CTSC | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| CTSC | ADSL | 25348397 | N/A | physical interaction | ComPPI |
| CTSC | ANKMY2 | 25348397 | N/A | physical interaction | ComPPI |
| CTSC | ARMC9 | 25348397 | N/A | physical interaction | ComPPI |
| CTSC | G3BP1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CTSC | TBC1D16 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CTSC | SGO1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CTSC | CTSC | 11726493 14525934 17353931 24234451 | physical association | anti bait coimmunoprecipitation,experimental interaction detection | HPRD,IntAct |