GENE：CTSH
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CTSH |
| FullNmae | cathepsin H |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2535 |
| EnsembleID | ENSG00000103811 |
| Uniprot | P09668 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CTSH | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| CTSH | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CTSH | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTSH | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CTSH | GO:0001656,GO:0001913,GO:0002250,GO:0002764,GO:0004175,GO:0004177,GO:0004197,GO:0004197,GO:0004197,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005764,GO:0005764,GO:0005829,GO:0006508,GO:0006508,GO:0006915,GO:0006955,GO:0008233,GO:0008234,GO:0008284,GO:0008656,GO:0008656,GO:0010628,GO:0010634,GO:0010813,GO:0010815,GO:0010952,GO:0010952,GO:0019882,GO:0030108,GO:0030335,GO:0031638,GO:0031648,GO:0032526,GO:0033619,GO:0034774,GO:0036464,GO:0043066,GO:0043129,GO:0043231,GO:0045766,GO:0051603,GO:0060448,GO:0062023,GO:0070062,GO:0070324,GO:0070371,GO:0097067,GO:0097208,GO:0097486,GO:1904724,GO:1904813,GO:2001235 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CTSH | hsa:1512 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| CTSH | hsa:1512 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | CTSH | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CTSH | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | CTSH | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | CTSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CTSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CTSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CTSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CTSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CTSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | CTSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | CTSH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TBC1D22B | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| CST1 | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| CTSL | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| NONO | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| ZIC1 | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| CSTA | CTSH | 12581647 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| SF3A1 | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| VCAM1 | CTSH | 22623428 24234451 25348397 | association | cross-linking study | ComPPI,IntAct |
| XRN1 | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| AIRE | CTSH | 25348397 | N/A | physical interaction | ComPPI |
| BGLAP | CTSH | 14525934 25348397 9076588 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CTSH | CSTB | 11514663 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CTSH | SFTPB | 25348397 | N/A | in vitro | ComPPI |
| CTSH | SLC25A41 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | TCTN3 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | MMRN1 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | SLCO6A1 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | POC5 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | CCDC103 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | BPNT1 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | HSPD1 | 25348397 | N/A | physical interaction | ComPPI |
| CTSH | BID | 14581476 27898060 | stimulant | N/A | OmniPath |
| CTSH | BGLAP | 27898060 9076588 | N/A | N/A | OmniPath |