Gene Information gene info

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GENE：PFN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PFN1
FullNmae profilin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8881
EnsembleID ENSG00000108518
Uniprot P07737

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PFN1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PFN1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PFN1 GO:0000774,GO:0001784,GO:0001843,GO:0003723,GO:0003779,GO:0003779,GO:0003785,GO:0005515,GO:0005546,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0005938,GO:0006357,GO:0010634,GO:0016020,GO:0030036,GO:0030833,GO:0030837,GO:0030838,GO:0031267,GO:0032232,GO:0032233,GO:0032781,GO:0045296,GO:0050804,GO:0050821,GO:0051497,GO:0060074,GO:0070062,GO:0070064,GO:0072562,GO:0098885,GO:0098978,GO:1900029

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PFN1 hsa:5216 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PFN1 hsa:5216 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PFN1 hsa:5216 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PFN1 hsa:5216 path:hsa05131 Shigellosis - Homo sapiens (human)
PFN1 hsa:5216 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PFN1 AFDN 10922060 23180781 physical association two hybrid InnateDB
IL7R PFN1 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
ISG15 PFN1 16009940 23180781 physical association unspecified method InnateDB
SRPK1 PFN1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PFN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PFN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PFN1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001CC379 PFN1 23430586 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001CC379 PFN1 21572407 22012620 23430586 23446348 24398324 25416803 26701625 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS00001C308D PFN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001012BC PFN1 22012620 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00001A7F58 PFN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 PFN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 PFN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 PFN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004DA9DB PFN1 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 PFN1 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000AF45F PFN1 21572407 23446348 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000246356 PFN1 21572407 22012620 23446348 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 PFN1 21572407 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000058DCD8 PFN1 22012620 23446348 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000016FF9C PFN1 21572407 22012620 23446348 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001D4A78 PFN1 21572407 22012620 23446348 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000014F13C PFN1 22012620 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B7E30 PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PFN1 22012620 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002394F5 PFN1 22012620 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003A5E54 PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 PFN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 PFN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002004E0 PFN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003CF1AD PFN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000004CA3 PFN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001919B0 PFN1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC PFN1 22135298 phosphorylation N/A PhosphoSite
KDR PFN1 22135298 phosphorylation N/A PhosphoSite
ROCK1 PFN1 22135298 phosphorylation N/A PhosphoSite
PFN1 VASP 25361965 interaction type N/A PTMCode2
VASP PFN1 25361965 interaction type N/A PTMCode2
PFN1 XPO6 25361965 interaction type N/A PTMCode2
XPO6 PFN1 25361965 interaction type N/A PTMCode2
PFN1 GPHN 25361965 interaction type N/A PTMCode2
GPHN PFN1 25361965 interaction type N/A PTMCode2
PFN1 WIPF2 25361965 interaction type N/A PTMCode2
WIPF2 PFN1 25361965 interaction type N/A PTMCode2
PFN1 MYPOP 25361965 interaction type N/A PTMCode2
MYPOP PFN1 25361965 interaction type N/A PTMCode2
PFN1 WASF1 25361965 interaction type N/A PTMCode2
WASF1 PFN1 25361965 interaction type N/A PTMCode2
PFN1 DNM2 25361965 interaction type N/A PTMCode2
DNM2 PFN1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC73 PFN1 25348397 N/A physical interaction ComPPI
WASL PFN1 10867004 14525934 25348397 27898060 9822597 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
VASP PFN1 10882740 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ISG15 PFN1 25348397 N/A physical interaction ComPPI
CFL1 PFN1 25348397 N/A physical interaction ComPPI
SET PFN1 25348397 N/A physical interaction ComPPI
GABARAPL2 PFN1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTB PFN1 10411937 14525934 19000816 19338310 24234451 25348397 physical association two hybrid,cosedimentation in solution,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
KEAP1 PFN1 25348397 N/A physical interaction ComPPI
MCM2 PFN1 25348397 N/A physical interaction ComPPI
MAP1LC3B PFN1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TMSB10 PFN1 25348397 N/A physical interaction ComPPI
TLE1 PFN1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIK3R1 PFN1 14525934 25348397 27898060 9801792 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
NCK1 PFN1 25348397 N/A physical interaction ComPPI
MAPK3 PFN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UNC119 PFN1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
JUN PFN1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CMA1 PFN1 11751973 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
LIG4 PFN1 25348397 N/A physical interaction ComPPI
CUL3 PFN1 25348397 N/A physical interaction ComPPI
YWHAZ PFN1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
PFN1 FMNL1 10958683 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PFN1 XPO6 14525934 14592989 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PFN1 ENAH 14525934 25348397 9473484 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PFN1 APBB1IP 14525934 15469846 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PFN1 WIPF2 12213210 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PFN1 GPHN 14525934 25348397 9473484 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PFN1 ACTA1 14525934 25348397 27898060 8413665 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PFN1 CRMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN1 LRIF1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PFN1 DLG5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN1 ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PFN1 MYPOP 14525934 15615774 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PFN1 DBN1 14525934 25348397 9473484 N/A experimental interaction detection,in vitro ComPPI,HPRD
PFN1 AFDN 25348397 N/A physical interaction ComPPI
PFN1 VIPR1 25348397 N/A physical interaction ComPPI
PFN1 UCHL5 25348397 N/A physical interaction ComPPI
PFN1 ELAVL1 25348397 N/A physical interaction ComPPI
PFN1 CDK2 25348397 N/A physical interaction ComPPI
PFN1 CAND1 25348397 N/A physical interaction ComPPI
PFN1 ACAA2 25348397 N/A physical interaction ComPPI
PFN1 SRPRB 25348397 N/A physical interaction ComPPI
PFN1 FN1 25348397 N/A physical interaction ComPPI
PFN1 VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 ITGA4 25348397 N/A physical interaction ComPPI
PFN1 RAD52 19338310 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PFN1 RAD51 19338310 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PFN1 ESR1 23576398 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
PFN1 SRPK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PFN1 ASB1 25348397 N/A physical interaction ComPPI
PFN1 ASB2 25348397 N/A physical interaction ComPPI
PFN1 ASB12 25348397 N/A physical interaction ComPPI
PFN1 MTMR8 25348397 N/A physical interaction ComPPI
PFN1 STUB1 24661873 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PFN1 FUS 25348397 N/A physical interaction ComPPI
PFN1 CUL7 25348397 N/A physical interaction ComPPI
PFN1 OBSL1 25348397 N/A physical interaction ComPPI
PFN1 HNRNPA1 25348397 N/A physical interaction ComPPI
PFN1 NTRK1 25348397 N/A physical interaction ComPPI
PFN1 DAZAP1 25348397 N/A physical interaction ComPPI
PFN1 SLC33A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PFN1 TRIM15 25348397 N/A physical interaction ComPPI
PFN1 CDH1 25348397 N/A physical interaction ComPPI
PFN1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 DLD 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 VDAC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 TRIM25 25348397 N/A physical interaction ComPPI
PFN1 UBE2A 25348397 N/A physical interaction ComPPI
PFN1 BRCA1 25348397 N/A physical interaction ComPPI
PFN1 CFTR 25348397 N/A physical interaction ComPPI
PFN1 UBC 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PFN1 UBA52 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PFN1 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PFN1 MAPK13 19135240 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PFN1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PFN1 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PFN1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
PFN1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
PFN1 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
UBB PFN1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A PFN1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
WASF1 PFN1 14525934 24234451 25348397 9843499 physical association experimental interaction detection,far western blotting,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RHOQ PFN1 10445846 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
YWHAQ PFN1 25348397 N/A physical interaction ComPPI
ATF2 PFN1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL53 PFN1 25348397 N/A physical interaction ComPPI
ZNF16 PFN1 21874239 24234451 25348397 physical association two hybrid ComPPI,IntAct
DNM2 PFN1 12419186 14525934 N/A experimental interaction detection HPRD
L1TD1 PFN1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
SRC PFN1 23000962 24747440 27898060 N/A N/A OmniPath
RHOA PFN1 22820501 27898060 stimulant N/A OmniPath
ROCK1 PFN1 18573880 22479341 25084196 25681442 27898060 inhibition N/A OmniPath
IL7R PFN1 20167604 27898060 N/A N/A OmniPath
PPP1CA PFN1 22479341 27898060 stimulant N/A OmniPath
ISG15 PFN1 16009940 27898060 N/A N/A OmniPath
PFN1 CDH4 22820501 27898060 stimulant N/A OmniPath

Visualization










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