GENE：CX3CL1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CX3CL1 |
| FullNmae | C-X3-C motif chemokine ligand 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10647 |
| EnsembleID | ENSG00000006210 |
| Uniprot | P78423 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CX3CL1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CX3CL1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CX3CL1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CX3CL1 | GO:0001774,GO:0001954,GO:0002052,GO:0002523,GO:0002548,GO:0002931,GO:0005102,GO:0005178,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005886,GO:0006935,GO:0006935,GO:0006952,GO:0006954,GO:0006955,GO:0007155,GO:0007186,GO:0007186,GO:0007267,GO:0008009,GO:0008009,GO:0008009,GO:0008009,GO:0008284,GO:0009986,GO:0010812,GO:0010976,GO:0016020,GO:0016020,GO:0016322,GO:0019221,GO:0030336,GO:0030593,GO:0030595,GO:0031664,GO:0031737,GO:0031737,GO:0031737,GO:0032233,GO:0032690,GO:0032691,GO:0032715,GO:0032720,GO:0032720,GO:0032914,GO:0033622,GO:0035425,GO:0042056,GO:0042995,GO:0043005,GO:0043025,GO:0043066,GO:0043123,GO:0043410,GO:0043547,GO:0045237,GO:0045944,GO:0048020,GO:0048167,GO:0048245,GO:0048247,GO:0048471,GO:0048661,GO:0050729,GO:0050767,GO:0050902,GO:0050918,GO:0051041,GO:0051092,GO:0051281,GO:0051897,GO:0051897,GO:0060055,GO:0060326,GO:0061518,GO:0070050,GO:0070098,GO:0070098,GO:0070374,GO:0070374,GO:0071346,GO:0071347,GO:0071356,GO:0097192,GO:0098609,GO:0098609,GO:0098883,GO:0110091,GO:1900450,GO:1903721,GO:1903979,GO:1904141,GO:2001223,GO:2001234,GO:2001240 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CX3CL1 | hsa:6376 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CX3CL1 | hsa:6376 | path:hsa04061 | Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human) |
| CX3CL1 | hsa:6376 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| CX3CL1 | hsa:6376 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| CX3CL1 | hsa:6376 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| CX3CL1 | hsa:6376 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | CX3CL1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CX3CL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| WT1 | CX3CL1 | 17430890 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CX3CL1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CX3CL1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001496AE | CX3CL1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075ABF4 | CX3CL1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | CX3CL1 | 25416803 26631623 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGB1 | CX3CL1 | 24234451 24789099 25348397 | physical association | pull down,enzyme linked immunosorbent assay | ComPPI,IntAct |
| ITGB3 | CX3CL1 | 23125415 24234451 24789099 25348397 | association,physical association | anti bait coimmunoprecipitation,pull down,surface plasmon resonance,enzyme linked immunosorbent assay | ComPPI,IntAct |
| ITGB2 | CX3CL1 | 24234451 24789099 25348397 | physical association | enzyme linked immunosorbent assay | ComPPI,IntAct |
| ITGB4 | CX3CL1 | 24234451 24789099 25348397 | physical association | enzyme linked immunosorbent assay | ComPPI,IntAct |
| ADAM15 | CX3CL1 | 24234451 24789099 25348397 | physical association | enzyme linked immunosorbent assay | ComPPI,IntAct |
| ITGA4 | CX3CL1 | 23125415 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CX3CL1 | CX3CR1 | 14525934 23125415 24234451 25348397 9390561 9931005 | physical association | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| CX3CL1 | FGG | 24234451 24789099 25348397 | physical association | fluorescence-activated cell sorting,enzyme linked immunosorbent assay | ComPPI,IntAct |
| CX3CL1 | FN1 | 24234451 24789099 25348397 | physical association | fluorescence-activated cell sorting | ComPPI,IntAct |
| CX3CL1 | ITGA5 | 23125415 24234451 25348397 | physical association | enzyme linked immunosorbent assay | ComPPI,IntAct |
| CX3CL1 | CX3CL1 | 10770945 14525934 | N/A | experimental interaction detection | HPRD |
| TP53 | CX3CL1 | 18431400 27898060 | stimulant | N/A | OmniPath |
| CX3CL1 | CX3CR1 | 10488147 11432858 14607932 24218476 27898060 9390561 9931005 | stimulant | N/A | OmniPath |