GENE：CX3CR1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CX3CR1 |
| FullNmae | C-X3-C motif chemokine receptor 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2558 |
| EnsembleID | ENSG00000168329 |
| Uniprot | P49238 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CX3CR1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CX3CR1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CX3CR1 | GO:0002052,GO:0002250,GO:0002282,GO:0002931,GO:0004930,GO:0004950,GO:0005515,GO:0005886,GO:0005886,GO:0006935,GO:0006955,GO:0006955,GO:0006968,GO:0007155,GO:0007155,GO:0007186,GO:0007200,GO:0007204,GO:0007267,GO:0007420,GO:0007613,GO:0008528,GO:0009611,GO:0009897,GO:0009986,GO:0009986,GO:0009986,GO:0016493,GO:0016495,GO:0019722,GO:0019957,GO:0019960,GO:0019960,GO:0021626,GO:0030336,GO:0030595,GO:0031737,GO:0032680,GO:0032691,GO:0032809,GO:0035176,GO:0035425,GO:0043005,GO:0045087,GO:0045428,GO:0045766,GO:0048167,GO:0048471,GO:0048874,GO:0050767,GO:0050769,GO:0050804,GO:0050901,GO:0051092,GO:0051897,GO:0060074,GO:0060326,GO:0061760,GO:0061760,GO:0070098,GO:0071222,GO:0071356,GO:0071560,GO:0090026,GO:0097447,GO:0098883,GO:0098883,GO:0110091,GO:0150090,GO:1900272,GO:1903721,GO:1904139,GO:1904141,GO:1904150,GO:2001234 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CX3CR1 | hsa:1524 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CX3CR1 | hsa:1524 | path:hsa04061 | Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human) |
| CX3CR1 | hsa:1524 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| CX3CR1 | hsa:1524 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CX3CR1 | NFATC2 | 15347678 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFATC1 | CX3CR1 | 15347678 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CCL26 | CX3CR1 | 20974991 23180781 | physical association | competition binding | InnateDB |
| CX3CR1 | CX3CL1 | 23180781 9390561 9931005 | physical association | saturation binding,solution state nmr | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CX3CR1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | CX3CR1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CX3CR1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | CX3CR1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CX3CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CX3CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | CX3CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CX3CR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGB3 | CX3CR1 | 23125415 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ITGA4 | CX3CR1 | 23125415 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CX3CL1 | CX3CR1 | 14525934 23125415 24234451 25348397 9390561 9931005 | physical association | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| CX3CL1 | CX3CR1 | 10488147 11432858 14607932 24218476 27898060 9390561 9931005 | stimulant | N/A | OmniPath |
| CCL26 | CX3CR1 | 20974991 27898060 | stimulant | N/A | OmniPath |