GENE：CYP1B1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CYP1B1 |
| FullNmae | cytochrome P450 family 1 subfamily B member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2597 |
| EnsembleID | ENSG00000138061 |
| Uniprot | Q16678 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CYP1B1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CYP1B1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CYP1B1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CYP1B1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CYP1B1 | GO:0001525,GO:0002930,GO:0004497,GO:0004497,GO:0004497,GO:0005506,GO:0005515,GO:0005739,GO:0005789,GO:0006304,GO:0006805,GO:0006809,GO:0007155,GO:0007584,GO:0008202,GO:0008210,GO:0008285,GO:0008584,GO:0008631,GO:0009404,GO:0009636,GO:0010575,GO:0014911,GO:0016125,GO:0016712,GO:0019369,GO:0019373,GO:0020037,GO:0030199,GO:0030325,GO:0030336,GO:0032088,GO:0032354,GO:0032355,GO:0033629,GO:0042537,GO:0042572,GO:0042572,GO:0042574,GO:0043065,GO:0043231,GO:0043534,GO:0043542,GO:0044849,GO:0045727,GO:0045766,GO:0046427,GO:0046466,GO:0046685,GO:0048514,GO:0061304,GO:0061548,GO:0070301,GO:0070330,GO:0071320,GO:0071356,GO:0071373,GO:0071387,GO:0071393,GO:0071407,GO:0071548,GO:0071603,GO:0071680,GO:0097267,GO:0101020,GO:0106256,GO:2000377,GO:2000379,GO:2000573 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CYP1B1 | hsa:1545 | path:hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| CYP1B1 | hsa:1545 | path:hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| CYP1B1 | hsa:1545 | path:hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| CYP1B1 | hsa:1545 | path:hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| CYP1B1 | hsa:1545 | path:hsa05204 | Chemical carcinogenesis - DNA adducts - Homo sapiens (human) |
| CYP1B1 | hsa:1545 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| CYP1B1 | hsa:1545 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| CYP1B1 | hsa:1545 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AHR | CYP1B1 | 12376470 12801909 16115918 17785579 19287966 19376845 21742528 24299737 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| ARNT | CYP1B1 | 12376470 12801909 16115918 19255421 19287966 19376845 21742528 24299737 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| BRCA1 | CYP1B1 | 16567799 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| ESR1 | CYP1B1 | 15126349 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| SP1 | CYP1B1 | 12801909 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| PRDM14 | CYP1B1 | 20953172 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CYP1B1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CYP1B1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CYP1B1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CYP1B1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EP300 | CYP1B1 | 20631054 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KAT2B | CYP1B1 | 20631054 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | CYP1B1 | 12801909 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | CYP1B1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000330617 | CYP1B1 | N/A 16982751 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miRSponge |
| URS0000330617 | CYP1B1 | 16982751 23592263 24614526 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay | TarBase |
| URS0000007FBA | CYP1B1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000170CF4 | CYP1B1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS000075AB14 | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A6D0C | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000521626 | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000034979B | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BBF48 | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008DA94 | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003E1A9 | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC0F4 | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | CYP1B1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | CYP1B1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | CYP1B1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DD591 | CYP1B1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000308E4D | CYP1B1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | CYP1B1 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EB9FC | CYP1B1 | 25416803 27495872 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000171525 | CYP1B1 | 25416803 25860934 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |