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GENE：DAB2IP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DAB2IP
FullNmae DAB2 interacting protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17294
EnsembleID ENSG00000136848
Uniprot Q5VWQ8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DAB2IP apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DAB2IP apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DAB2IP GO:0000122,GO:0000122,GO:0001525,GO:0001933,GO:0001933,GO:0005096,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007049,GO:0007252,GO:0008285,GO:0008625,GO:0010596,GO:0010633,GO:0010633,GO:0010719,GO:0010719,GO:0010976,GO:0016525,GO:0017124,GO:0019900,GO:0019901,GO:0019901,GO:0021814,GO:0021819,GO:0030139,GO:0030163,GO:0030424,GO:0030425,GO:0030948,GO:0031334,GO:0031434,GO:0031435,GO:0032088,GO:0032266,GO:0032809,GO:0034144,GO:0034260,GO:0034260,GO:0034620,GO:0035148,GO:0035591,GO:0035924,GO:0035924,GO:0036312,GO:0036324,GO:0042059,GO:0042177,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043087,GO:0043122,GO:0043124,GO:0043184,GO:0043254,GO:0043407,GO:0043407,GO:0043410,GO:0043507,GO:0043539,GO:0043548,GO:0044300,GO:0044301,GO:0044877,GO:0045087,GO:0045296,GO:0045732,GO:0045892,GO:0045944,GO:0046330,GO:0046580,GO:0048147,GO:0048812,GO:0050680,GO:0051721,GO:0051726,GO:0051898,GO:0070059,GO:0070273,GO:0070317,GO:0070373,GO:0071222,GO:0071347,GO:0071356,GO:0071364,GO:0071889,GO:0071901,GO:0071902,GO:0072577,GO:0090090,GO:0090090,GO:0090129,GO:1900006,GO:1900744,GO:1900747,GO:1901800,GO:1903896,GO:1990032,GO:1990597,GO:2001224,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DAB2IP hsa:153090 path:hsa04210 Apoptosis - Homo sapiens (human)
DAB2IP hsa:153090 path:hsa04668 TNF signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFRSF1A DAB2IP 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23180781 23430059 23510023 23567181 23769623 24092389 26192618 26201938 26801188 28765050 8663014 8910423 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TNF DAB2IP 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26192618 26201938 26801188 28765050 8663014 8910423 interaction type N/A ACSN
RIPK1 DAB2IP 11274345 15310755 17389591 18641653 19498109 19524512 19524513 19632174 21133840 21232017 23010170 23180781 26192618 26587781 26653790 28574505 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TRAF2 DAB2IP 10734135 15310755 18292600 26192618 8974401 association N/A ACSN
TRADD DAB2IP 10734135 15310755 18292600 23180781 26192618 8974401 association,physical association anti tag coimmunoprecipitation ACSN,InnateDB
DAB2IP TRAF2 15310755 23180781 physical association anti tag coimmunoprecipitation InnateDB
DAB2IP MAP3K5 15310755 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR DAB2IP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DAB2IP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DAB2IP 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DAB2IP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C DAB2IP 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 DAB2IP 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DAB2IP 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000254A6 DAB2IP 18684991 rna interference,inhibition western blot,quantitative reverse transcription pcr miRSponge
URS00000254A6 DAB2IP 18684991 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000035CC3E DAB2IP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 DAB2IP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002FC5B0 DAB2IP 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 DAB2IP 22473208 25416803 27430302 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00001DABC0 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002A79D1 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000116F83 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000048D44E DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A939F DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007A060 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F9738 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CE046 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000334286 DAB2IP 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RIPK1 DAB2IP 22135298 phosphorylation N/A PhosphoSite
DAB2IP DAB2 25361965 interaction type N/A PTMCode2
DAB2 DAB2IP 25361965 interaction type N/A PTMCode2
DAB2IP MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 DAB2IP 25361965 interaction type N/A PTMCode2
DAB2IP DAB1 25361965 interaction type N/A PTMCode2
DAB1 DAB2IP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SKP1 DAB2IP 25348397 N/A physical interaction ComPPI
CBY1 DAB2IP 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DAB2 DAB2IP 25348397 N/A physical interaction ComPPI
HRAS DAB2IP 25348397 N/A physical interaction ComPPI
PIK3R1 DAB2IP 25348397 N/A physical interaction ComPPI
FBXW7 DAB2IP 25348397 N/A physical interaction ComPPI
GSK3B DAB2IP 20080667 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBX1 DAB2IP 25348397 N/A physical interaction ComPPI
NTRK1 DAB2IP 25348397 N/A physical interaction ComPPI
DAB1 DAB2IP 11812785 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CDH1 DAB2IP 25348397 N/A physical interaction ComPPI
AXIN1 DAB2IP 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
SNX17 DAB2IP 25348397 N/A physical interaction ComPPI
MAP3K5 DAB2IP 12813029 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
TNFRSF1A DAB2IP 25348397 N/A physical interaction ComPPI
TP73 DAB2IP 25348397 N/A physical interaction ComPPI
XPO1 DAB2IP 25348397 N/A physical interaction ComPPI
YWHAQ DAB2IP 25348397 N/A physical interaction ComPPI
TRAF2 DAB2IP 25348397 N/A physical interaction ComPPI
CUL1 DAB2IP 25348397 N/A physical interaction ComPPI
CUL4A DAB2IP 25348397 N/A physical interaction ComPPI
ANKS1A DAB2IP 25348397 N/A physical interaction ComPPI
TP63 DAB2IP 25348397 N/A physical interaction ComPPI
RIPK1 DAB2IP 25348397 N/A physical interaction ComPPI
TRIM25 DAB2IP 25348397 N/A physical interaction ComPPI
TRADD DAB2IP 25348397 N/A physical interaction ComPPI
CGN DAB2IP 25348397 N/A physical interaction ComPPI
AKT1 DAB2IP 25348397 N/A physical interaction ComPPI
EXOSC9 DAB2IP 25348397 N/A physical interaction ComPPI
DAB2IP TP53 25348397 N/A physical interaction ComPPI
DAB2IP RFPL3 25348397 N/A physical interaction ComPPI
DAB2IP RAB4B 25348397 N/A physical interaction ComPPI
DAB2IP MIA 25348397 N/A physical interaction ComPPI
DAB2IP IWS1 25348397 N/A physical interaction ComPPI
DAB2IP UGGT1 25348397 N/A physical interaction ComPPI
DAB2IP RNASEH2B 25348397 N/A physical interaction ComPPI
DAB2IP CTDSPL 25348397 N/A physical interaction ComPPI
DAB2IP CLIP1 25348397 N/A physical interaction ComPPI
DAB2IP MCC 25348397 N/A physical interaction ComPPI
DAB2IP CD83 25348397 N/A physical interaction ComPPI
DAB2IP PACC1 25348397 N/A physical interaction ComPPI
DAB2IP DAB2IP 12813029 24234451 self interaction anti bait coimmunoprecipitation IntAct
DAB2IP GATA1 27858941 27898060 stimulant N/A OmniPath
TRAF2 DAB2IP 15310755 17389591 24912918 27898060 stimulant N/A OmniPath
DAB2IP HRAS 27858941 27898060 inhibition N/A OmniPath
FBXW7 DAB2IP 27858941 27898060 inhibition N/A OmniPath
SKP2 DAB2IP 27858941 27898060 inhibition N/A OmniPath
AKT1 DAB2IP 19903888 24912918 27858941 27898060 inhibition N/A OmniPath
DAB2IP MAP3K5 12813029 15310755 17389591 19903888 27858941 27898060 stimulant N/A OmniPath
MAP3K5 DAB2IP 12813029 15310755 17389591 19903888 27898060 N/A N/A OmniPath
DAB2IP PIK3CA 27858941 27898060 inhibition N/A OmniPath
DAB2IP ERN1 27858941 27898060 stimulant N/A OmniPath
TRADD DAB2IP 15310755 27898060 N/A N/A OmniPath
DAB2IP PIK3R1 19903888 27858941 27898060 inhibition N/A OmniPath
DAB2IP AR 27858941 27898060 inhibition N/A OmniPath
DAB2IP NRAS 27858941 27898060 inhibition N/A OmniPath
RIPK1 DAB2IP 15310755 17389591 27858941 27898060 stimulant N/A OmniPath
TNFRSF1A DAB2IP 15310755 27898060 N/A N/A OmniPath
GSK3B DAB2IP 17389591 20080667 27898060 N/A N/A OmniPath
DAB2IP GSK3B 20080667 27898060 stimulant N/A OmniPath
DAB2IP STAT3 26512963 27898060 inhibition N/A OmniPath
DAB2IP JAK2 27858941 27898060 inhibition N/A OmniPath
DAB2 DAB2IP 11812785 27858941 27898060 stimulant N/A OmniPath
SMURF1 DAB2IP 27858941 27898060 inhibition N/A OmniPath
DAB2IP KRAS 27858941 27898060 inhibition N/A OmniPath

Visualization










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