Gene Information gene info

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GENE：DEDD2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DEDD2
FullNmae death effector domain containing 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24450
EnsembleID ENSG00000160570
Uniprot Q8WXF8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DEDD2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DEDD2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DEDD2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DEDD2 GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0005730,GO:0006396,GO:0008625,GO:0008625,GO:0016075,GO:0019725,GO:0030159,GO:0030262,GO:0035556,GO:0045892,GO:2001238

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DEDD2 CASP8 12527898 23180781 physical association anti tag coimmunoprecipitation InnateDB
DEDD2 CASP10 12527898 23180781 physical association anti tag coimmunoprecipitation InnateDB
DEDD2 DEDD2 12527898 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
DEDD2 DEDD 12527898 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DEDD2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DEDD2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DEDD2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C DEDD2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DEDD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DEDD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DEDD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DEDD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
RHOXF2 DEDD2 25348397 N/A physical interaction ComPPI
CDK6 DEDD2 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CASP8 DEDD2 11965497 12527898 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NR2E3 DEDD2 25348397 N/A physical interaction ComPPI
CASP10 DEDD2 12527898 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CFLAR DEDD2 11741985 11965497 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF3C3 DEDD2 11965497 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
DEDD DEDD2 11965497 12527898 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RBFOX2 DEDD2 25348397 N/A physical interaction ComPPI
DEDD2 HNRNPAB 25348397 N/A physical interaction ComPPI
DEDD2 ATG16L1 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
DEDD2 CDCA7L 25348397 N/A physical interaction ComPPI
DEDD2 DEDD2 11741985 11965497 12527898 14525934 N/A experimental interaction detection HPRD
DEDD2 CASP8 11965497 12527898 27898060 N/A N/A OmniPath
DEDD2 CASP10 12527898 27898060 N/A N/A OmniPath
CASP10 DEDD2 12527898 27898060 N/A N/A OmniPath

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