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GENE：DEPTOR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DEPTOR
FullNmae DEP domain containing MTOR interacting protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:22953
EnsembleID ENSG00000155792
Uniprot Q8TB45

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DEPTOR autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DEPTOR autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DEPTOR apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DEPTOR apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DEPTOR GO:0004860,GO:0005515,GO:0005765,GO:0006469,GO:0006469,GO:0010508,GO:0030291,GO:0032007,GO:0035556,GO:0045792,GO:0070300,GO:1903940,GO:1903940,GO:1903940,GO:1904262,GO:1904262,GO:1904262,GO:2001236

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DEPTOR hsa:64798 path:hsa04140 Autophagy - animal - Homo sapiens (human)
DEPTOR hsa:64798 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MLST8 DEPTOR 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
MTOR DEPTOR 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RPTOR DEPTOR 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
DEPTOR MAPKAP1 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RAC1 DEPTOR 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RICTOR DEPTOR 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RHEB DEPTOR 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 26597054 28216025 interaction type N/A ACSN
DEPTOR FOXP3 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
SQSTM1 DEPTOR 15340068 16252010 20531300 21981924 25002027 26192618 26587781 28574505 interaction type N/A ACSN
DEPTOR MYC 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
DEPTOR GZMA 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
DEPTOR IL10 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
DEPTOR IFNG 12150925 12408816 12906785 15755954 16469695 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
DEPTOR GZMB 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ESR1 DEPTOR 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 DEPTOR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 DEPTOR 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 DEPTOR 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C DEPTOR 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
AR DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DEPTOR 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004719AB DEPTOR 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA DEPTOR 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0B46 DEPTOR 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 DEPTOR 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031BC7D DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000116F83 DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015D23B DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C0D3F DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D2333 DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB35 DEPTOR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000ED600 DEPTOR 25416803 28262546 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
RPS6KA1 DEPTOR 22135298 phosphorylation N/A PhosphoSite
MTOR DEPTOR 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 DEPTOR 22135298 phosphorylation N/A PhosphoSite
RPS6KB1 DEPTOR 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CUL5 DEPTOR 25348397 N/A physical interaction ComPPI
FBXW7 DEPTOR 25348397 N/A physical interaction ComPPI
BTRC DEPTOR 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HNRNPL DEPTOR 25348397 N/A physical interaction ComPPI
RPS6KA1 DEPTOR 25348397 N/A physical interaction ComPPI
XPO1 DEPTOR 25348397 N/A physical interaction ComPPI
TRAF1 DEPTOR 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RPS6KB1 DEPTOR 25348397 N/A physical interaction ComPPI
CUL1 DEPTOR 25348397 N/A physical interaction ComPPI
PSME3 DEPTOR 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MTOR DEPTOR 19446321 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 DEPTOR 19446321 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXW11 DEPTOR 25348397 N/A physical interaction ComPPI
LNX1 DEPTOR 25348397 N/A physical interaction ComPPI
RPTOR DEPTOR 19446321 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RICTOR DEPTOR 19446321 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHKA DEPTOR 25348397 N/A physical interaction ComPPI
TRIM41 DEPTOR 25348397 N/A physical interaction ComPPI
TRIM16 DEPTOR 25348397 N/A physical interaction ComPPI
FBXO25 DEPTOR 25348397 N/A physical interaction ComPPI
APP DEPTOR 25348397 N/A physical interaction ComPPI
NXF1 DEPTOR 25348397 N/A physical interaction ComPPI
DEPTOR CCDC110 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CSNK1A1 DEPTOR 22017875 22017876 22017877 27898060 inhibition N/A OmniPath
RPS6KA1 DEPTOR 22017877 27898060 inhibition N/A OmniPath
MTOR DEPTOR 19446321 22017875 22017877 27898060 inhibition N/A OmniPath
DEPTOR MTOR 19446321 22017875 22017877 27898060 inhibition N/A OmniPath
RPS6KB1 DEPTOR 19446321 22017876 27898060 inhibition N/A OmniPath

Visualization










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