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GENE：E2F2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol E2F2
FullNmae E2F transcription factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3114
EnsembleID ENSG00000007968
Uniprot Q14209

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
E2F2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
E2F2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
E2F2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
E2F2 GO:0000083,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0000987,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0006367,GO:0035189,GO:0043565,GO:0045944,GO:0046983,GO:0051726,GO:0072332,GO:0090575,GO:0090575,GO:0090575,GO:1903671,GO:1990086,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
E2F2 hsa:1870 path:hsa01522 Endocrine resistance - Homo sapiens (human)
E2F2 hsa:1870 path:hsa04110 Cell cycle - Homo sapiens (human)
E2F2 hsa:1870 path:hsa04218 Cellular senescence - Homo sapiens (human)
E2F2 hsa:1870 path:hsa04934 Cushing syndrome - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05160 Hepatitis C - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05161 Hepatitis B - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05200 Pathways in cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05214 Glioma - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05215 Prostate cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05218 Melanoma - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05219 Bladder cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05224 Breast cancer - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
E2F2 hsa:1870 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR E2F2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 E2F2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 E2F2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 E2F2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 E2F2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 E2F2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 E2F2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 E2F2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 E2F2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA E2F2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF E2F2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS E2F2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 E2F2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RB1 E2F2 9671466 trascriptional regulation,stimulation inferred by curator TFlink
MYC E2F2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 E2F2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 E2F2 19759154 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000122ED0 E2F2 19528081 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 E2F2 20179198 22743998 25416803 26997445 27174918 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000009262D E2F2 19528081 25416803 mrna cleavage,inhibition chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr TarBase
URS0000122ED0 E2F2 19528081 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AA464 E2F2 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 E2F2 19759154 20584899 22473208 25128227 25416803 26967247 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS0000096022 E2F2 20371350 25416803 26701625 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00001597DC E2F2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000272A92 E2F2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F E2F2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 E2F2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002A79D1 E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 E2F2 23592263 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004BCD9C E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 E2F2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF E2F2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C E2F2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000049704B E2F2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 E2F2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 E2F2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 E2F2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 E2F2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 E2F2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA E2F2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 E2F2 25416803 26498144 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000324096 E2F2 25416803 27520092 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001799A3 E2F2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RYBP E2F2 12411495 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ARID3A E2F2 14525934 15017387 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SP1 E2F2 14525934 25348397 27898060 8657141 8657142 9694791 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
GRB2 E2F2 25348397 N/A physical interaction ComPPI
RB1 E2F2 12502741 14525934 16360038 17380128 24234451 25348397 7739537 8832394 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,comigration in non denaturing gel electrophoresis,in vitro,in vivo ComPPI,HPRD,IntAct
FHL2 E2F2 25348397 N/A physical interaction ComPPI
KMT2D E2F2 25348397 N/A physical interaction ComPPI
E2F1 E2F2 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
E2F2 TFDP1 14525934 24234451 25348397 27705803 7739537 8755520 association experimental interaction detection,physical interaction,comigration in non denaturing gel electrophoresis,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
E2F2 YY1 12411495 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
E2F2 BRD2 25348397 N/A physical interaction,in vivo ComPPI
E2F2 KMT5A 12411495 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
E2F2 CDK3 11733001 14525934 25348397 8846921 N/A experimental interaction detection,in vivo ComPPI,HPRD
E2F2 BCAR1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
E2F2 KMT2A 25348397 N/A physical interaction ComPPI
E2F2 ATAD2 25348397 N/A physical interaction ComPPI
E2F2 ELAVL1 25348397 N/A physical interaction ComPPI
E2F2 RBL1 25348397 N/A physical interaction ComPPI
E2F2 GIT2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
E2F2 GNB5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
E2F2 SHMT2 25348397 N/A physical interaction ComPPI
E2F2 MOV10 25348397 N/A physical interaction ComPPI
E2F2 UCHL5 25348397 N/A physical interaction ComPPI
E2F2 L3MBTL3 17517653 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F2 MCPH1 18660752 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ILP2 E2F2 25348397 N/A two hybrid ComPPI
SOTV E2F2 25348397 N/A two hybrid ComPPI
E2F2 HEP 14605208 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RB1 E2F2 12502741 17380128 17488475 22569856 27898060 7739537 8246996 8657117 8832394 inhibition N/A OmniPath
E2F2 PCNA 11491305 18319725 27898060 stimulant N/A OmniPath
E2F2 EZH2 14532106 18319725 27898060 stimulant N/A OmniPath
E2F2 CDKN2A 11883935 18319725 27898060 stimulant N/A OmniPath
E2F2 CCNB1 15510213 18319725 27898060 stimulant N/A OmniPath
E2F2 EED 14532106 18319725 27898060 stimulant N/A OmniPath

Visualization










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