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GENE：EIF2AK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF2AK3
FullNmae eukaryotic translation initiation factor 2 alpha kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3255
EnsembleID ENSG00000172071
Uniprot Q9NZJ5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF2AK3 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
EIF2AK3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EIF2AK3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EIF2AK3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EIF2AK3 GO:0001501,GO:0001503,GO:0001525,GO:0002063,GO:0004672,GO:0004674,GO:0004694,GO:0004694,GO:0004694,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005783,GO:0005783,GO:0005783,GO:0005789,GO:0005789,GO:0005789,GO:0005829,GO:0006468,GO:0006919,GO:0006983,GO:0007029,GO:0010575,GO:0010628,GO:0010998,GO:0016020,GO:0017148,GO:0018105,GO:0019722,GO:0019899,GO:0019903,GO:0030282,GO:0030968,GO:0030968,GO:0031018,GO:0031642,GO:0032055,GO:0032057,GO:0034198,GO:0034976,GO:0036492,GO:0036492,GO:0036492,GO:0036499,GO:0042149,GO:0042802,GO:0045943,GO:0046777,GO:0046777,GO:0048009,GO:0048471,GO:0051879,GO:0060734,GO:0070417,GO:0106310,GO:1900182,GO:1902235,GO:1990737

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EIF2AK3 hsa:9451 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa04140 Autophagy - animal - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa04210 Apoptosis - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05010 Alzheimer disease - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05012 Parkinson disease - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05020 Prion disease - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05160 Hepatitis C - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05162 Measles - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
EIF2AK3 hsa:9451 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SUZ12 EIF2AK3 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR EIF2AK3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 EIF2AK3 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 EIF2AK3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EIF2AK3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 EIF2AK3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 EIF2AK3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 EIF2AK3 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 EIF2AK3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 EIF2AK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 EIF2AK3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 EIF2AK3 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 EIF2AK3 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 EIF2AK3 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
EIF2AK3 EIF2S1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SFTPC EIF2AK3 25348397 N/A physical interaction ComPPI
GRIA3 EIF2AK3 25348397 N/A physical interaction ComPPI
COPS5 EIF2AK3 25348397 N/A physical interaction ComPPI
NFE2L2 EIF2AK3 14517290 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
VAPA EIF2AK3 25348397 N/A physical interaction ComPPI
HSP90AA1 EIF2AK3 12446770 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CANX EIF2AK3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSPA5 EIF2AK3 11907036 14525934 24234451 25348397 27238082 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
HSP90B1 EIF2AK3 11907036 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IKBKB EIF2AK3 10848580 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EIF2S1 EIF2AK3 10542257 11555640 14525934 16288713 1677563 25348397 8099443 9819435 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF1 EIF2AK3 25348397 N/A physical interaction ComPPI
CHRND EIF2AK3 25348397 N/A physical interaction ComPPI
EIF2AK3 DNAJC3 12446838 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EIF2AK3 HSP90AA2P 25348397 N/A physical interaction ComPPI
EIF2AK3 BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF2AK3 SUZ12 25348397 N/A physical interaction ComPPI
EIF2AK3 HLA-DRA 25348397 N/A physical interaction ComPPI
EIF2AK3 HLA-C 25348397 N/A physical interaction ComPPI
EIF2AK3 OGFOD3 25348397 N/A physical interaction ComPPI
EIF2AK3 GLT8D2 25348397 N/A physical interaction ComPPI
EIF2AK3 HLA-E 25348397 N/A physical interaction ComPPI
EIF2AK3 CHRNA9 25348397 N/A physical interaction ComPPI
EIF2AK3 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EIF2AK3 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EIF2AK3 AP5Z1 25348397 N/A physical interaction ComPPI
EIF2AK3 FOXK1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
EIF2AK3 FOXK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
EIF2AK3 RPN2 25348397 N/A physical interaction ComPPI
EIF2AK3 DLK2 25348397 N/A physical interaction ComPPI
EIF2AK3 B4GAT1 25348397 N/A physical interaction ComPPI
EIF2AK3 SCN3B 25348397 N/A physical interaction ComPPI
EIF2AK3 P2RX2 25348397 N/A physical interaction ComPPI
EIF2AK3 ASIC4 25348397 N/A physical interaction ComPPI
EIF2AK3 PCDHGB4 25348397 N/A physical interaction ComPPI
EIF2AK3 TMPRSS3 25348397 N/A physical interaction ComPPI
EIF2AK3 PCDHA4 25348397 N/A physical interaction ComPPI
EIF2AK3 HLA-DRB1 25348397 N/A physical interaction ComPPI
EIF2AK3 PCDHA12 25348397 N/A physical interaction ComPPI
EIF2AK3 NCEH1 25348397 N/A physical interaction ComPPI
EIF2AK3 PCDH20 25348397 N/A physical interaction ComPPI
EIF2AK3 PCDHB11 25348397 N/A physical interaction ComPPI
EIF2AK3 ASIC1 25348397 N/A physical interaction ComPPI
EIF2AK3 ARSG 25348397 N/A physical interaction ComPPI
EIF2AK3 ILF3 25348397 N/A physical interaction ComPPI
ILF2 EIF2AK3 25348397 N/A physical interaction ComPPI
PLGRKT EIF2AK3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TGIF2LY EIF2AK3 25348397 N/A physical interaction ComPPI
EIF2AK3 EIF2AK3 11907036 24234451 physical association anti tag coimmunoprecipitation,cosedimentation through density gradient IntAct
EIF2AK3 EIF2S1 10542257 11555640 16288713 1677563 17998206 27898060 8099443 9819435 9930704 inhibition,stimulant N/A OmniPath
EIF2AK3 APAF1 16595687 27898060 inhibition N/A OmniPath
HSPA5 EIF2AK3 11907036 18624755 20371724 27898060 inhibition N/A OmniPath
EIF2AK3 EIF2A 16595687 25329545 27898060 inhibition,stimulant N/A OmniPath
MAPK14 EIF2AK3 14676213 27898060 N/A N/A OmniPath
EIF2AK3 SLC7A1 19029953 27898060 stimulant N/A OmniPath
EIF2AK3 NFE2L2 14517290 27898060 stimulant N/A OmniPath
EIF2AK3 BIRC2 19029953 27898060 stimulant N/A OmniPath
EIF2AK3 BIRC3 19029953 27898060 stimulant N/A OmniPath
EIF2AK3 KRT18 27898060 7523419 9524113 N/A N/A OmniPath
EIF2AK3 ATF4 15550948 19029953 27898060 stimulant N/A OmniPath
DNAJC3 EIF2AK3 12446838 25329545 27898060 inhibition N/A OmniPath

Visualization










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