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GENE：EIF5A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF5A
FullNmae eukaryotic translation initiation factor 5A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3300
EnsembleID ENSG00000132507
Uniprot P63241

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF5A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EIF5A GO:0003723,GO:0003723,GO:0003746,GO:0003746,GO:0005515,GO:0005634,GO:0005642,GO:0005643,GO:0005737,GO:0005789,GO:0005829,GO:0006414,GO:0006414,GO:0016020,GO:0017070,GO:0033209,GO:0043022,GO:0045901,GO:0045905,GO:0045944,GO:0098586,GO:1902255

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 EIF5A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 EIF5A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EIF5A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EIF5A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EIF5A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D EIF5A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 EIF5A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F EIF5A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 EIF5A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B EIF5A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 EIF5A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 EIF5A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F0F49 EIF5A 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 EIF5A 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 EIF5A 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C EIF5A 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000002103A EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002A79D1 EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000014F13C EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002394F5 EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D1FC EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AB35 EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005485E8 EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001919B0 EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000036B845 EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003AD2AA EIF5A 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EIF2S1 EIF5A 25361965 interaction type N/A PTMCode2
EIF5A EIF2S1 25361965 interaction type N/A PTMCode2
EEF2 EIF5A 25361965 interaction type N/A PTMCode2
EIF5A EEF2 25361965 interaction type N/A PTMCode2
XPO1 EIF5A 25361965 interaction type N/A PTMCode2
EIF5A XPO1 25361965 interaction type N/A PTMCode2
EIF5A RPL5 25361965 interaction type N/A PTMCode2
RPL5 EIF5A 25361965 interaction type N/A PTMCode2
EIF5A EIF1 25361965 interaction type N/A PTMCode2
EIF1 EIF5A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRX EIF5A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ATP5F1B EIF5A 25348397 N/A physical interaction ComPPI
NPM1 EIF5A 25348397 N/A physical interaction ComPPI
MEOX2 EIF5A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VCP EIF5A 25348397 N/A physical interaction ComPPI
KEAP1 EIF5A 25348397 N/A physical interaction ComPPI
MCM2 EIF5A 25348397 N/A physical interaction ComPPI
DDX17 EIF5A 25348397 N/A physical interaction ComPPI
DUSP12 EIF5A 25348397 N/A physical interaction ComPPI
PICK1 EIF5A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
REL EIF5A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CHST15 EIF5A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN EIF5A 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 EIF5A 25348397 N/A physical interaction ComPPI
KAT2B EIF5A 22771473 24234451 25348397 27898060 acetylation reaction acetylase assay ComPPI,IntAct,OmniPath
TGM2 EIF5A 14525934 25348397 27898060 9442029 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
U2AF2 EIF5A 25348397 N/A physical interaction ComPPI
VAPA EIF5A 25348397 N/A physical interaction ComPPI
CDH1 EIF5A 25348397 N/A physical interaction ComPPI
TNS2 EIF5A 24234451 25348397 28330616 association pull down ComPPI,IntAct
XRN2 EIF5A 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CD247 EIF5A 24234451 24502978 25348397 association pull down ComPPI,IntAct
DUSP7 EIF5A 24234451 25348397 28330616 association pull down ComPPI,IntAct
CFTR EIF5A 25348397 N/A physical interaction ComPPI
EWSR1 EIF5A 25348397 N/A physical interaction ComPPI
SDCBP EIF5A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCCIP EIF5A 25348397 N/A physical interaction ComPPI
XPO1 EIF5A 10381392 14525934 22939629 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
HUWE1 EIF5A 25348397 N/A physical interaction ComPPI
CUL2 EIF5A 25348397 N/A physical interaction ComPPI
VHL EIF5A 25348397 N/A physical interaction ComPPI
GABARAP EIF5A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF5A DHPS 10229683 12562768 12788913 14525934 24234451 25348397 25416956 7929297 physical association experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
EIF5A RPL5 14525934 25348397 27898060 9465063 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
EIF5A DOHH 14525934 17213197 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
EIF5A ELAVL1 25348397 N/A physical interaction ComPPI
EIF5A TCF3 25348397 N/A physical interaction ComPPI
EIF5A MACF1 25348397 N/A physical interaction ComPPI
EIF5A IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF5A GDA 25348397 N/A physical interaction ComPPI
EIF5A GNS 25348397 N/A physical interaction ComPPI
EIF5A MVD 25348397 N/A physical interaction ComPPI
EIF5A PEPD 25348397 N/A physical interaction ComPPI
EIF5A TYMS 25348397 N/A physical interaction ComPPI
EIF5A WDR1 25348397 N/A physical interaction ComPPI
EIF5A GLS 25348397 N/A physical interaction ComPPI
EIF5A HSPD1 25348397 N/A physical interaction ComPPI
EIF5A STUB1 24509416 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EIF5A DCP2 25348397 N/A physical interaction ComPPI
EIF5A CUL7 25348397 N/A physical interaction ComPPI
EIF5A ESR1 25348397 N/A physical interaction ComPPI
EIF5A SOD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF5A RETREG2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF5A EIF2S2 25348397 N/A physical interaction ComPPI
EIF5A DUSP13 25348397 N/A physical interaction ComPPI
EIF5A DUSP13 25348397 N/A physical interaction ComPPI
EIF5A DUSP19 25348397 N/A physical interaction ComPPI
EIF5A DUSP2 25348397 N/A physical interaction ComPPI
EIF5A DUSP26 25348397 N/A physical interaction ComPPI
EIF5A DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF5A DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF5A SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF5A FOXA1 25348397 N/A physical interaction ComPPI
EIF5A CCND2 25348397 N/A physical interaction ComPPI
EIF5A UBE2A 25348397 N/A physical interaction ComPPI
EIF5A MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF5A GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF5A MEI4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF5A GSC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF5A LBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF5A PTPN3 24234451 25348397 28330616 association pull down ComPPI,IntAct
EIF5A PPTC7 24234451 25348397 28330616 association pull down ComPPI,IntAct
EIF5A PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
XPO4 EIF5A 10944119 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ATF2 EIF5A 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
METTL14 EIF5A 24234451 29507755 association anti tag coimmunoprecipitation IntAct
DHPS EIF5A 10229683 12562768 12788913 25416956 27898060 7929297 N/A N/A OmniPath

Visualization










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