GENE：EPO
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EPO |
| FullNmae | erythropoietin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3415 |
| EnsembleID | ENSG00000130427 |
| Uniprot | P01588 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EPO | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| EPO | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EPO | GO:0000122,GO:0001666,GO:0005125,GO:0005125,GO:0005128,GO:0005128,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006953,GO:0007165,GO:0007566,GO:0008015,GO:0008284,GO:0008284,GO:0009651,GO:0009986,GO:0010523,GO:0010976,GO:0030218,GO:0030218,GO:0030295,GO:0032496,GO:0033028,GO:0033189,GO:0033574,GO:0038162,GO:0038162,GO:0042104,GO:0042531,GO:0042541,GO:0043249,GO:0043627,GO:0044297,GO:0045666,GO:0045893,GO:0046579,GO:0046579,GO:0048678,GO:0051602,GO:0055093,GO:0070374,GO:0070555,GO:0071474,GO:0071548,GO:1902219,GO:1902251,GO:2001258 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EPO | hsa:2056 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| EPO | hsa:2056 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| EPO | hsa:2056 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| EPO | hsa:2056 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| EPO | hsa:2056 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| EPO | hsa:2056 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| EPO | hsa:2056 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HIF1A | EPO | 15674338 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EPO | RB1 | 15674338 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EPO | EPOR | 21889455 23180781 23331499 9774108 | stimulation,physical association | x-ray crystallography | InnateDB,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | EPO | 16471262 8677751 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| GATA2 | EPO | 8677751 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| GATA3 | EPO | 8677751 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| HNF4A | EPO | 18971253 7891708 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| RORA | EPO | 7891708 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| NR2F1 | EPO | 7891708 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| NR2C1 | EPO | 7891708 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| CEBPA | EPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | EPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | EPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | EPO | 16281953 18971253 8089148 8663540 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | EPO | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ARNT | EPO | 8663540 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EP300 | EPO | 20368990 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NCOA1 | EPO | 20368990 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NCOA3 | EPO | 20368990 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | EPO | 14741200 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD4 | EPO | 14741200 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | EPO | 14741200 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | EPO | 14741200 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | EPO | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EP300 | EPO | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| EPOR | EPO | 10318834 14525934 24234451 25348397 29997244 9774108 9808045 | physical association | experimental interaction detection,x-ray crystallography,physical interaction,biochemical,in vivo,luminescence based mammalian interactome mapping | ComPPI,HPRD,IntAct |
| EPHB4 | EPO | 24234451 25348397 26481148 | physical association | anti bait coimmunoprecipitation,solid phase assay | ComPPI,IntAct |
| DOK2 | EPO | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| EPO | GINM1 | 25348397 | N/A | physical interaction | ComPPI |
| EPO | EPOR | 10318834 15358619 16982323 17327410 18586265 21889455 27898060 8662939 9030560 9442088 9774108 9808045 | stimulant | N/A | OmniPath |
| EPO | DAPK2 | 18535204 27898060 | stimulant | N/A | OmniPath |