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GENE：ERCC6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERCC6
FullNmae ERCC excision repair 6, chromatin remodeling factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3438
EnsembleID ENSG00000225830
Uniprot P0DP91|Q03468

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERCC6 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC6 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ERCC6 GO:0000012,GO:0000077,GO:0000303,GO:0003677,GO:0003682,GO:0003682,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005730,GO:0006283,GO:0006283,GO:0006284,GO:0006290,GO:0006338,GO:0006362,GO:0006366,GO:0006979,GO:0006979,GO:0007254,GO:0008023,GO:0008094,GO:0008094,GO:0008094,GO:0008630,GO:0009636,GO:0010165,GO:0010224,GO:0010332,GO:0016887,GO:0022008,GO:0030182,GO:0030296,GO:0031175,GO:0032784,GO:0032786,GO:0034243,GO:0035066,GO:0035264,GO:0042262,GO:0045494,GO:0045739,GO:0045739,GO:0045943,GO:0045944,GO:0045945,GO:0060261,GO:0090734,GO:0097680,GO:0110016,GO:0140658,GO:1905168,GO:2001033

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERCC6 hsa:2074 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ERCC6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 ERCC6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ERCC6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ERCC6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ERCC6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ERCC6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 ERCC6 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 ERCC6 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ERCC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001D69F6 ERCC6 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ABL1 ERCC6 22135298 phosphorylation N/A PhosphoSite
ERCC6 XPA 25361965 interaction type N/A PTMCode2
XPA ERCC6 25361965 interaction type N/A PTMCode2
ERCC6 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 ERCC6 25361965 interaction type N/A PTMCode2
ERCC6 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 ERCC6 25361965 interaction type N/A PTMCode2
ERCC8 ERCC6 25361965 interaction type N/A PTMCode2
ERCC6 ERCC8 25361965 interaction type N/A PTMCode2
TP53 ERCC6 25361965 interaction type N/A PTMCode2
ERCC6 TP53 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PCNA ERCC6 25348397 N/A physical interaction ComPPI
PCNA ERCC6 25348397 N/A physical interaction ComPPI
VCP ERCC6 25348397 N/A physical interaction ComPPI
VCP ERCC6 25348397 N/A physical interaction ComPPI
ERCC3 ERCC6 25348397 N/A physical interaction ComPPI
ERCC3 ERCC6 25348397 N/A physical interaction ComPPI
H4C1 ERCC6 25348397 N/A physical interaction ComPPI
H4C1 ERCC6 25348397 N/A physical interaction ComPPI
RPL10 ERCC6 25348397 N/A physical interaction ComPPI
RPL10 ERCC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP7 ERCC6 25348397 N/A physical interaction ComPPI
USP7 ERCC6 25348397 N/A physical interaction ComPPI
KAT2B ERCC6 25348397 N/A physical interaction ComPPI
KAT2B ERCC6 25348397 N/A physical interaction ComPPI
UBC ERCC6 25348397 N/A physical interaction ComPPI
UBC ERCC6 25348397 N/A physical interaction ComPPI
PARP1 ERCC6 14525934 16107709 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PARP1 ERCC6 25348397 N/A physical interaction ComPPI
SSBP1 ERCC6 25348397 N/A physical interaction ComPPI
SSBP1 ERCC6 25348397 N/A physical interaction ComPPI
RPA1 ERCC6 25348397 N/A physical interaction ComPPI
RPA1 ERCC6 25348397 N/A physical interaction ComPPI
KSR2 ERCC6 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
HNRNPU ERCC6 25348397 N/A physical interaction ComPPI
HNRNPU ERCC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OGG1 ERCC6 25348397 N/A physical interaction ComPPI
OGG1 ERCC6 25348397 N/A physical interaction ComPPI
XAB2 ERCC6 10944529 14525934 24234451 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
XAB2 ERCC6 25348397 N/A physical interaction ComPPI
XPA ERCC6 14525934 25348397 8999876 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XPA ERCC6 25348397 N/A physical interaction ComPPI
CBX4 ERCC6 25348397 N/A tandem affinity purification ComPPI
CUL4B ERCC6 25348397 N/A physical interaction ComPPI
CUL4B ERCC6 25348397 N/A physical interaction ComPPI
MDM2 ERCC6 25348397 N/A physical interaction ComPPI
MDM2 ERCC6 25348397 N/A physical interaction ComPPI
SPTA1 ERCC6 25348397 N/A physical interaction ComPPI
SPTA1 ERCC6 25348397 N/A physical interaction ComPPI
MPHOSPH8 ERCC6 25348397 N/A physical interaction ComPPI
MPHOSPH8 ERCC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL4A ERCC6 25348397 N/A physical interaction ComPPI
CUL4A ERCC6 25348397 N/A physical interaction ComPPI
POLD1 ERCC6 25348397 N/A physical interaction ComPPI
POLD1 ERCC6 25348397 N/A physical interaction ComPPI
GTF2E2 ERCC6 14525934 25348397 8999876 N/A experimental interaction detection,in vitro ComPPI,HPRD
CHEK2 ERCC6 14525934 25348397 9450932 N/A experimental interaction detection,in vitro ComPPI,HPRD
POLR2A ERCC6 10944529 14525934 16916636 20541997 24234451 25348397 27898060 9372911 association,physical association coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
POLR2A ERCC6 25348397 N/A physical interaction ComPPI
COPS3 ERCC6 25348397 N/A physical interaction ComPPI
COPS3 ERCC6 25348397 N/A physical interaction ComPPI
COPS4 ERCC6 25348397 N/A physical interaction ComPPI
COPS4 ERCC6 25348397 N/A physical interaction ComPPI
COPS6 ERCC6 25348397 N/A physical interaction ComPPI
COPS6 ERCC6 25348397 N/A physical interaction ComPPI
ERCC5 ERCC6 14525934 25348397 8652557 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERCC5 ERCC6 25348397 N/A physical interaction ComPPI
BAZ1B ERCC6 25348397 N/A physical interaction ComPPI
BAZ1B ERCC6 25348397 N/A physical interaction ComPPI
CUL7 ERCC6 25348397 N/A physical interaction ComPPI
CUL7 ERCC6 25348397 N/A physical interaction ComPPI
H3C1 ERCC6 25348397 N/A physical interaction ComPPI
H3C1 ERCC6 25348397 N/A physical interaction ComPPI
CAND1 ERCC6 25348397 N/A physical interaction ComPPI
CAND1 ERCC6 25348397 N/A physical interaction ComPPI
CDK2AP1 ERCC6 25348397 N/A physical interaction ComPPI
CDK2AP1 ERCC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NFKB1 ERCC6 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
BAX ERCC6 25348397 N/A physical interaction ComPPI
BAX ERCC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOP56 ERCC6 25348397 N/A physical interaction ComPPI
NOP56 ERCC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDB1 ERCC6 25348397 N/A physical interaction ComPPI
DDB1 ERCC6 25348397 N/A physical interaction ComPPI
BRCA1 ERCC6 25348397 N/A physical interaction ComPPI
BRCA1 ERCC6 25348397 N/A physical interaction ComPPI
HECW2 ERCC6 25348397 N/A physical interaction ComPPI
HECW2 ERCC6 25348397 N/A physical interaction ComPPI
RNF11 ERCC6 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RNF11 ERCC6 25348397 N/A physical interaction ComPPI
POLR1A ERCC6 25348397 N/A physical interaction ComPPI
POLR1A ERCC6 25348397 N/A physical interaction ComPPI
H2AC4 ERCC6 25348397 N/A physical interaction ComPPI
H2AC4 ERCC6 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
H2BC3 ERCC6 25348397 N/A physical interaction ComPPI
H2BC3 ERCC6 25348397 N/A physical interaction ComPPI
ERCC8 ERCC6 14525934 25348397 7664335 N/A anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERCC8 ERCC6 25348397 N/A physical interaction ComPPI
ERCC2 ERCC6 25348397 N/A physical interaction ComPPI
ERCC2 ERCC6 25348397 N/A physical interaction ComPPI
ERCC4 ERCC6 25348397 N/A physical interaction ComPPI
ERCC4 ERCC6 25348397 N/A physical interaction ComPPI
H2AC20 ERCC6 25348397 N/A physical interaction ComPPI
H2AC20 ERCC6 25348397 N/A physical interaction ComPPI
ERCC6 TP53 10882116 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ERCC6 HMGN1 25348397 N/A physical interaction ComPPI
ERCC6 BIVM 25348397 N/A physical interaction ComPPI
ERCC6 CBX6 25348397 N/A physical interaction ComPPI
ERCC6 HDAC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGN1 ERCC6 25348397 N/A physical interaction ComPPI
TP53 ERCC6 25348397 N/A physical interaction ComPPI
HDAC1 ERCC6 25348397 N/A physical interaction ComPPI
BIVM ERCC6 25348397 N/A physical interaction ComPPI
ERCC6 CBX6 25348397 N/A physical interaction ComPPI
IKBIP ERCC6 24234451 30021884 physical association cross-linking study IntAct
ABL1 ERCC6 17626041 24234451 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,pull down,protein kinase assay,confocal microscopy IntAct
ERCC6 NEIL1 19179336 27898060 stimulant N/A OmniPath
EHMT2 ERCC6 18438403 27898060 N/A N/A OmniPath
ERCC6 TP53 10882116 18784753 19221478 22032989 27898060 7663514 inhibition N/A OmniPath
ABL1 ERCC6 17626041 27898060 stimulant N/A OmniPath
ERCC6 XAB2 10944529 17145710 27898060 stimulant N/A OmniPath
ERCC6 APEX1 17567611 27898060 inhibition N/A OmniPath

Visualization










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