GENE：EYA1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EYA1 |
| FullNmae | EYA transcriptional coactivator and phosphatase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3519 |
| EnsembleID | ENSG00000104313 |
| Uniprot | Q99502 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EYA1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| EYA1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| EYA1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| EYA1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EYA1 | GO:0001656,GO:0001658,GO:0003151,GO:0003723,GO:0004725,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006302,GO:0006338,GO:0007389,GO:0007501,GO:0007605,GO:0009653,GO:0010212,GO:0014706,GO:0016604,GO:0016925,GO:0017018,GO:0030154,GO:0032993,GO:0035909,GO:0042473,GO:0042474,GO:0045664,GO:0045739,GO:0045739,GO:0045944,GO:0046872,GO:0048665,GO:0048704,GO:0048752,GO:0048856,GO:0050673,GO:0050679,GO:0060037,GO:0071600,GO:0072513,GO:0090103,GO:0097192,GO:0140793,GO:2001240 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EYA1 | hsa:2138 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | EYA1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| TFAP2C | EYA1 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | EYA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EYA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | EYA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | EYA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | EYA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | EYA1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PTPN9 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXW7 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| FZR1 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| GSK3B | EYA1 | 24752894 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| RPA1 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| MYC | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| RPA2 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| RPA3 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| TMPO | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| BANF1 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| SPAG9 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| SIX3 | EYA1 | 10490620 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| H2AX | EYA1 | 19234442 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DACH1 | EYA1 | 25348397 | N/A | two hybrid,in vitro | ComPPI |
| DPYSL3 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| SIX1 | EYA1 | 11734542 12874121 14525934 15226428 15492887 24234451 25348397 | physical association | two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| EYA1 | SIX2 | 11734542 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| EYA1 | GNAI2 | 11950062 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| EYA1 | GRPEL1 | 25348397 | N/A | physical interaction | ComPPI |
| EYA1 | SIX4 | 25348397 | N/A | physical interaction | ComPPI |
| EYA1 | TMPO | 25348397 | N/A | physical interaction | ComPPI |
| EYA1 | CERT1 | 25348397 | N/A | physical interaction | ComPPI |
| GNAZ | EYA1 | 11950062 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| ATP6V1B2 | EYA1 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90B1 | EYA1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PAX2 | EYA1 | 16916509 27898060 | N/A | N/A | OmniPath |
| EYA1 | SHARPIN | 20956555 27898060 | N/A | N/A | OmniPath |
| EYA1 | POLR2A | 14628042 27898060 | N/A | N/A | OmniPath |
| AKT1 | EYA1 | 24954506 27898060 | N/A | N/A | OmniPath |
| SIX1 | EYA1 | 11734542 12874121 15226428 15492887 17035528 26186194 27898060 | inhibition | N/A | OmniPath |
| EYA1 | H2AX | 19234442 19351884 20965415 27898060 | inhibition | N/A | OmniPath |
| EYA1 | FGF3 | 12874121 27898060 | stimulant | N/A | OmniPath |