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GENE：EYA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EYA2
FullNmae EYA transcriptional coactivator and phosphatase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3520
EnsembleID ENSG00000064655
Uniprot O00167

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EYA2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EYA2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EYA2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EYA2 GO:0000287,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006281,GO:0006338,GO:0007501,GO:0014706,GO:0030154,GO:0045739,GO:0048856,GO:0097192,GO:0097345,GO:0140793,GO:2001240

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR EYA2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 EYA2 12629508 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 EYA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EYA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C EYA2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 EYA2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EYA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 EYA2 24508260 25416803 26837415 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SIX1 EYA2 25361965 interaction type N/A PTMCode2
EYA2 SIX1 25361965 interaction type N/A PTMCode2
GNAZ EYA2 25361965 interaction type N/A PTMCode2
EYA2 GNAZ 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RBPMS EYA2 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ROR2 EYA2 25348397 N/A physical interaction ComPPI
BAG3 EYA2 25348397 N/A physical interaction ComPPI
LZTS2 EYA2 25348397 N/A physical interaction ComPPI
NDUFAF3 EYA2 25348397 N/A physical interaction ComPPI
DMRTB1 EYA2 25348397 N/A two hybrid,physical interaction ComPPI
NDUFAF4 EYA2 25348397 N/A physical interaction ComPPI
TLE3 EYA2 25348397 N/A physical interaction ComPPI
NCOR2 EYA2 25348397 N/A physical interaction ComPPI
NCOR1 EYA2 25348397 N/A physical interaction ComPPI
PHKG2 EYA2 25348397 N/A physical interaction ComPPI
TFAP2A EYA2 25348397 N/A physical interaction ComPPI
KMT2D EYA2 25348397 N/A physical interaction ComPPI
NME1 EYA2 25348397 N/A physical interaction ComPPI
AKR7A2 EYA2 25348397 N/A physical interaction ComPPI
DUSP1 EYA2 25348397 N/A physical interaction ComPPI
ARID1B EYA2 25348397 N/A physical interaction ComPPI
PUM1 EYA2 25348397 N/A physical interaction ComPPI
KDM6A EYA2 25348397 N/A physical interaction ComPPI
PHKA2 EYA2 25348397 N/A physical interaction ComPPI
VAPB EYA2 25348397 N/A physical interaction ComPPI
MMS19 EYA2 25348397 N/A physical interaction ComPPI
RAVER1 EYA2 25348397 N/A physical interaction ComPPI
TFAP2C EYA2 24234451 24835590 25348397 physical association two hybrid ComPPI,IntAct
CIC EYA2 25348397 N/A physical interaction ComPPI
BCOR EYA2 25348397 N/A physical interaction ComPPI
PHKA1 EYA2 25348397 N/A physical interaction ComPPI
NBN EYA2 25348397 N/A physical interaction ComPPI
CGN EYA2 25348397 N/A physical interaction ComPPI
SIX1 EYA2 10906137 19497856 21516116 23435380 24234451 25348397 27898060 physical association two hybrid,molecular sieving,x-ray crystallography,physical interaction ComPPI,IntAct,OmniPath
GNB2 EYA2 25348397 N/A physical interaction ComPPI
GNAI2 EYA2 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
TRPS1 EYA2 25348397 N/A physical interaction ComPPI
ARID1A EYA2 25348397 N/A physical interaction ComPPI
PIGT EYA2 25348397 N/A physical interaction ComPPI
CNOT1 EYA2 25348397 N/A physical interaction ComPPI
SIX2 EYA2 25348397 N/A physical interaction ComPPI
AGO2 EYA2 25348397 N/A physical interaction ComPPI
EYA2 SIX4 25348397 N/A physical interaction,in vitro ComPPI
EYA2 ZNF609 25348397 N/A physical interaction ComPPI
EYA2 GSE1 25348397 N/A physical interaction ComPPI
EYA2 CEP85 25348397 N/A physical interaction ComPPI
EYA2 RBM20 25348397 N/A physical interaction ComPPI
EYA2 PRRC2B 25348397 N/A physical interaction ComPPI
EYA2 TNRC6A 25348397 N/A physical interaction ComPPI
EYA2 SEC16A 25348397 N/A physical interaction ComPPI
EYA2 HELZ 25348397 N/A physical interaction ComPPI
EYA2 CCDC18 25348397 N/A physical interaction ComPPI
EYA2 ENTR1 25348397 N/A physical interaction ComPPI
EYA2 KIF14 25348397 N/A physical interaction ComPPI
EYA2 CEP192 25348397 N/A physical interaction ComPPI
EYA2 MIA3 25348397 N/A physical interaction ComPPI
EYA2 THEM6 25348397 N/A physical interaction ComPPI
EYA2 CGRRF1 25348397 N/A physical interaction ComPPI
EYA2 TMEM9 25348397 N/A physical interaction ComPPI
EYA2 PHKB 25348397 N/A physical interaction ComPPI
EYA2 GPX8 25348397 N/A physical interaction ComPPI
EYA2 FAM3A 25348397 N/A physical interaction ComPPI
EYA2 GMPPB 25348397 N/A physical interaction ComPPI
EYA2 TMCO1 25348397 N/A physical interaction ComPPI
EYA2 DCD 25348397 N/A physical interaction ComPPI
EYA2 CYC1 25348397 N/A physical interaction ComPPI
EYA2 NDUFA9 25348397 N/A physical interaction ComPPI
EYA2 CCDC28A 25348397 N/A physical interaction ComPPI
EYA2 GDAP1 25348397 N/A physical interaction ComPPI
EYA2 QPCTL 25348397 N/A physical interaction ComPPI
EYA2 TIMM21 25348397 N/A physical interaction ComPPI
EYA2 ETFB 25348397 N/A physical interaction ComPPI
EYA2 SCO1 25348397 N/A physical interaction ComPPI
EYA2 ACAD9 25348397 N/A physical interaction ComPPI
EYA2 DCAF11 25348397 N/A physical interaction ComPPI
EYA2 IDE 25348397 N/A physical interaction ComPPI
EYA2 DNAJB12 25348397 N/A physical interaction ComPPI
EYA2 GMPPA 25348397 N/A physical interaction ComPPI
EYA2 MAIP1 25348397 N/A physical interaction ComPPI
EYA2 OXA1L 25348397 N/A physical interaction ComPPI
EYA2 PNKD 25348397 N/A physical interaction ComPPI
EYA2 CCDC85C 25348397 N/A physical interaction ComPPI
EYA2 AATK 25348397 N/A physical interaction ComPPI
GNAZ EYA2 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI

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