Gene Information gene info

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GENE：TNFSF12

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNFSF12
FullNmae TNF superfamily member 12
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11927
EnsembleID ENSG00000239697
Uniprot O43508

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNFSF12 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFSF12 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFSF12 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFSF12 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TNFSF12 GO:0001525,GO:0001938,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0030154,GO:0043542,GO:0045732,GO:0045766,GO:0048018,GO:0048471,GO:0097191,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNFSF12 hsa:8742 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFSF12 TNFRSF12A 23180781 23750247 physical association far western blotting InnateDB

Source Target Pmid Interactiontype Methods Database
FOXP3 TNFSF12 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TNFSF12 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TNFSF12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TNFSF12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TNFSF12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TNFSF12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TNFSF12 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002075FA TNFSF12 19478946 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00002075FA TNFSF12 19478946 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000F31F4 TNFSF12 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 TNFSF12 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
TNFSF12 AGGF1 25361965 interaction type N/A PTMCode2
AGGF1 TNFSF12 25361965 interaction type N/A PTMCode2
TNFSF12 TNFRSF12A 25361965 interaction type N/A PTMCode2
TNFRSF12A TNFSF12 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SGTA TNFSF12 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LMNA TNFSF12 25348397 N/A physical interaction ComPPI
LYN TNFSF12 25348397 N/A physical interaction ComPPI
TNFRSF25 TNFSF12 11094155 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TRAF2 TNFSF12 23524849 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFSF13B TNFSF12 25348397 N/A physical interaction ComPPI
BIRC2 TNFSF12 23524849 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF12A TNFSF12 11728344 12529173 14525934 23438059 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,enzyme linked immunosorbent assay,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
TNFSF12 AGGF1 14525934 14961121 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TNFSF12 OTUB1 23524849 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFSF12 DDIT3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNFSF12 TNFRSF12A 11728344 12529173 12787562 23438059 23750247 27898060 stimulant N/A OmniPath

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