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GENE：EYA3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EYA3
FullNmae EYA transcriptional coactivator and phosphatase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3521
EnsembleID ENSG00000158161
Uniprot Q99504

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EYA3 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EYA3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EYA3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EYA3 GO:0004725,GO:0004725,GO:0004725,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005813,GO:0006302,GO:0006302,GO:0006338,GO:0007601,GO:0009653,GO:0010212,GO:0030154,GO:0045739,GO:0045739,GO:0046872,GO:0048856,GO:0140793,GO:2001240

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR EYA3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EYA3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EYA3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 EYA3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 EYA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 EYA3 22723308 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002152A8 EYA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 EYA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000019D79B EYA3 22723308 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000C4DB5 EYA3 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 EYA3 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 EYA3 22135298 phosphorylation N/A PhosphoSite
ATM EYA3 22135298 phosphorylation N/A PhosphoSite
SIX1 EYA3 25361965 interaction type N/A PTMCode2
EYA3 SIX1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRK EYA3 25348397 N/A two hybrid,physical interaction ComPPI
TBP EYA3 25348397 N/A physical interaction ComPPI
FHL2 EYA3 25348397 N/A physical interaction ComPPI
STIP1 EYA3 25348397 N/A physical interaction ComPPI
NME1 EYA3 25348397 N/A physical interaction ComPPI
CACYBP EYA3 25348397 N/A physical interaction ComPPI
EWSR1 EYA3 25348397 N/A physical interaction ComPPI
ZDHHC17 EYA3 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PTRH2 EYA3 25348397 N/A physical interaction ComPPI
TRIM25 EYA3 25348397 N/A physical interaction ComPPI
H2AX EYA3 19234442 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DACH1 EYA3 25348397 N/A in vitro ComPPI
SIX1 EYA3 12215533 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EYA3 SIX2 12215533 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EYA3 SIX4 10490620 12215533 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EYA3 SIX5 10490620 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EYA3 SKI 25348397 N/A physical interaction ComPPI
EYA3 TCEAL1 25348397 N/A physical interaction ComPPI
EYA3 MTMR3 25348397 N/A physical interaction ComPPI
EYA3 SOAT1 25348397 N/A physical interaction ComPPI
EYA3 MTMR2 25348397 N/A physical interaction ComPPI
EYA3 GRPEL1 25348397 N/A physical interaction ComPPI
EYA3 TMEM126A 25348397 N/A physical interaction ComPPI
EYA3 TSEN34 25348397 N/A physical interaction ComPPI
EYA3 TIMM21 25348397 N/A physical interaction ComPPI
EYA3 THTPA 25348397 N/A physical interaction ComPPI
EYA3 DIS3L 25348397 N/A physical interaction ComPPI
EYA3 CCDC28A 25348397 N/A physical interaction ComPPI
EYA3 STX17 25348397 N/A physical interaction ComPPI
EYA3 POLR2A 14628042 27898060 N/A N/A OmniPath
EYA3 H2AX 19234442 19351884 20965415 27898060 inhibition N/A OmniPath

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