Gene Information gene info

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GENE：FGA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FGA
FullNmae fibrinogen alpha chain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3661
EnsembleID ENSG00000171560
Uniprot P02671

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FGA mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FGA apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FGA apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FGA GO:0002250,GO:0005102,GO:0005198,GO:0005198,GO:0005201,GO:0005201,GO:0005515,GO:0005576,GO:0005576,GO:0005577,GO:0005577,GO:0005615,GO:0005783,GO:0005788,GO:0005886,GO:0007160,GO:0009897,GO:0009986,GO:0031091,GO:0031093,GO:0031639,GO:0034116,GO:0034116,GO:0042730,GO:0042730,GO:0043152,GO:0045087,GO:0045907,GO:0045921,GO:0046872,GO:0050714,GO:0050839,GO:0051258,GO:0051258,GO:0051592,GO:0062023,GO:0065003,GO:0065003,GO:0070062,GO:0070374,GO:0070374,GO:0070527,GO:0070527,GO:0070527,GO:0072377,GO:0072377,GO:0072378,GO:0072562,GO:0090277,GO:0090277,GO:1900026,GO:1902042,GO:1902042,GO:1903561,GO:2000352,GO:2000352

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FGA hsa:2243 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
FGA hsa:2243 path:hsa04611 Platelet activation - Homo sapiens (human)
FGA hsa:2243 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
FGA hsa:2243 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FGA SPARC 16263253 23180781 physical association surface plasmon resonance InnateDB
PITX3 FGA 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 FGA 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA FGA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FGA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FGA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFCP2 FGA 10455131 trascriptional regulation,stimulation inferred by curator TFlink
USF1 FGA N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 FGA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002E92A8 FGA 20570858 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000076995 FGA 20570858 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000272A3D FGA 20570858 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000081E1F FGA 20570858 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000081E1F FGA 20570858 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000272A3D FGA 20570858 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002E92A8 FGA 20570858 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000076995 FGA 20570858 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 FGA 22135298 phosphorylation N/A PhosphoSite
FGA F2 25361965 interaction type N/A PTMCode2
F2 FGA 25361965 interaction type N/A PTMCode2
FGA CDH5 25361965 interaction type N/A PTMCode2
CDH5 FGA 25361965 interaction type N/A PTMCode2
ITGB3 FGA 25361965 interaction type N/A PTMCode2
FGA ITGB3 25361965 interaction type N/A PTMCode2
ITGA2B FGA 25361965 interaction type N/A PTMCode2
FGA ITGA2B 25361965 interaction type N/A PTMCode2
FGB FGA 25361965 interaction type N/A PTMCode2
FGA FGB 25361965 interaction type N/A PTMCode2
F13A1 FGA 25361965 interaction type N/A PTMCode2
FGA F13A1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 FGA 10954706 24234451 25348397 physical association two hybrid ComPPI,IntAct
IGHG1 FGA 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RING1 FGA 25348397 N/A physical interaction ComPPI
H2BC4 FGA 25348397 N/A physical interaction ComPPI
KHDRBS2 FGA 25348397 N/A physical interaction ComPPI
F2 FGA 14525934 1587268 2133223 24234451 25241761 25348397 2742826 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
UBC FGA 25348397 N/A physical interaction ComPPI
APOA1 FGA 15174051 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
CDH5 FGA 11900554 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PLAT FGA 11170397 14525934 25348397 3088041 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
THBS1 FGA 14525934 25348397 27898060 9867861 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
SERPINF2 FGA 10963790 14525934 14751930 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SERPINA5 FGA 14525934 25348397 27898060 8384496 8589203 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ITGB3 FGA 11460491 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGA2B FGA 11460491 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRRC2A FGA 14525934 14667819 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MAPK6 FGA 25348397 N/A physical interaction ComPPI
FGB FGA 12356313 14525934 14992584 18294856 21475196 24234451 25348397 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,atomic force microscopy ComPPI,HPRD,IntAct
TRIM33 FGA 25348397 N/A physical interaction ComPPI
DDX19B FGA 25348397 N/A physical interaction ComPPI
MIS12 FGA 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
ALDH2 FGA 25348397 N/A physical interaction ComPPI
KLK6 FGA 12878203 24234451 25348397 protein cleavage protease assay ComPPI,IntAct
NID1 FGA 14525934 1680863 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
F13A1 FGA 10956659 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
FGA FGG 12356313 14525934 14992584 18294856 21475196 24234451 25348397 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,atomic force microscopy ComPPI,HPRD,IntAct
FGA HRG 14525934 25348397 27898060 9276466 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
FGA ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FGA FN1 25348397 N/A physical interaction ComPPI
FGA ASB6 25348397 N/A physical interaction ComPPI
FGA ASB7 25348397 N/A physical interaction ComPPI
FGA H2BC11 25348397 N/A physical interaction ComPPI
FGA SNX27 25348397 N/A physical interaction ComPPI
FGA IGHA1 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
FGA FAM20C 22582013 24234451 25348397 26091039 phosphorylation reaction protein kinase assay ComPPI,IntAct
PASK FGA 21418524 24234451 25348397 phosphorylation reaction peptide array ComPPI,IntAct
FGA FGA 14525934 9689040 N/A experimental interaction detection HPRD
FGA SPARC 16263253 27898060 N/A N/A OmniPath
FGA ITGB1 15031111 27898060 7716514 stimulant N/A OmniPath
FGA ITGAM 16601240 27898060 N/A N/A OmniPath
CSNK2A1 FGA 27898060 3477999 N/A N/A OmniPath
INSR FGA 1956339 27898060 6255944 N/A N/A OmniPath
FGA ITGA5 15031111 27898060 N/A N/A OmniPath
FGA ITGAX 27898060 7679388 stimulant N/A OmniPath
FGA ITGAV 15031111 27898060 N/A N/A OmniPath

Visualization










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